BMC Biology,
Journal Year:
2018,
Volume and Issue:
16(1)
Published: Aug. 20, 2018
Between
the
1930s
and
50s,
evolutionary
biologists
developed
a
successful
theory
of
why
organisms
age,
firmly
rooted
in
population
genetic
principles.
By
1980s
evolution
aging
had
secure
experimental
basis.
Since
force
selection
declines
with
evolves
due
to
mutation
accumulation
or
benefit
fitness
early
life.
Here
we
review
major
insights
challenges
that
have
emerged
over
last
35
years:
does
not
always
necessarily
decline
age;
higher
extrinsic
(i.e.,
environmentally
caused)
mortality
accelerate
aging;
conserved
pathways
control
rate;
senescence
patterns
are
more
diverse
than
previously
thought;
is
universal;
trade-offs
involving
lifespan
can
be
'broken';
might
'druggable';
human
life
expectancy
continues
rise
but
compressing
late-life
morbidity
remains
pressing
challenge.
Cell,
Journal Year:
2018,
Volume and Issue:
174(4), P. 982 - 998.e20
Published: June 18, 2018
The
diversity
of
cell
types
and
regulatory
states
in
the
brain,
how
these
change
during
aging,
remains
largely
unknown.
We
present
a
single-cell
transcriptome
atlas
entire
adult
Drosophila
melanogaster
brain
sampled
across
its
lifespan.
Cell
clustering
identified
87
initial
clusters
that
are
further
subclustered
validated
by
targeted
cell-sorting.
Our
data
show
high
granularity
identify
wide
range
types.
Gene
network
analyses
using
SCENIC
revealed
heterogeneity
linked
to
energy
consumption.
During
RNA
content
declines
exponentially
without
affecting
neuronal
identity
old
brains.
This
covers
nearly
all
cells
normal
provides
tools
study
cellular
alongside
other
mammalian
datasets
our
unique
analysis
platform:
SCope
(http://scope.aertslab.org).
These
results,
together
with
SCope,
allow
comprehensive
exploration
transcriptional
an
aging
brain.
Disease Models & Mechanisms,
Journal Year:
2017,
Volume and Issue:
10(5), P. 499 - 502
Published: May 1, 2017
ABSTRACT
Neurodegeneration
is
a
feature
of
many
debilitating,
incurable
diseases
that
are
rapidly
rising
in
prevalence,
such
as
Parkinson's
disease.
There
an
urgent
need
to
develop
new
and
more
effective
therapeutic
strategies
combat
these
devastating
diseases.
Models
–
from
cell-based
systems,
unicellular
organisms,
complex
animals
have
proven
be
useful
tool
help
the
research
community
shed
light
on
mechanisms
underlying
neurodegenerative
diseases,
advances
now
begun
provide
promising
avenues.
In
this
themed
issue
Disease
&
Mechanisms,
special
collection
articles
focused
introduced.
The
includes
original
insights
into
pathophysiology
revealing
candidate
biomarkers
or
targets.
Some
describe
disease
model
enables
deeper
exploration
key
mechanisms.
We
also
present
series
reviews
highlight
some
recent
translational
made
studies
Editorial,
we
summarize
featured
collection,
emphasizing
impact
model-based
exciting
area
research.
