Seminars in Cancer Biology, Journal Year: 2019, Volume and Issue: 66, P. 89 - 100
Published: March 14, 2019
Language: Английский
Cell, Journal Year: 2017, Volume and Issue: 171(2), P. 273 - 285
Published: Oct. 1, 2017
Language: Английский
Citations
5550
Cell Death and Differentiation, Journal Year: 2018, Volume and Issue: 25(3), P. 486 - 541
Published: Jan. 23, 2018
Over the past decade, Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for definition and interpretation of cell death from morphological, biochemical, functional perspectives. Since field continues to expand novel mechanisms that orchestrate multiple pathways are unveiled, we propose an updated classification subroutines focusing mechanistic essential (as opposed correlative dispensable) aspects process. As provide molecularly oriented definitions terms including intrinsic apoptosis, extrinsic mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic death, NETotic lysosome-dependent autophagy-dependent immunogenic cellular senescence, mitotic catastrophe, discuss utility neologisms refer highly specialized instances these processes. The mission NCCD is a widely accepted nomenclature in support continued development field.
Language: Английский
Citations
5365
Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(4), P. 266 - 282
Published: Jan. 25, 2021
Language: Английский
Citations
4434
Nature, Journal Year: 2019, Volume and Issue: 575(7784), P. 688 - 692
Published: Oct. 21, 2019
Language: Английский
Citations
2634
Cell Research, Journal Year: 2020, Volume and Issue: 31(2), P. 107 - 125
Published: Dec. 2, 2020
Abstract Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form non-apoptotic cell in 2012, there has been mounting interest process and function ferroptosis. Ferroptosis occur two major pathways, extrinsic or transporter-dependent pathway intrinsic enzyme-regulated pathway. is caused by a redox imbalance between production oxidants antioxidants, which driven abnormal expression activity multiple redox-active enzymes that produce detoxify free radicals lipid oxidation products. Accordingly, precisely regulated at levels, including epigenetic, transcriptional, posttranscriptional posttranslational layers. The transcription factor NFE2L2 plays central role upregulating anti-ferroptotic defense, whereas selective autophagy may promote ferroptotic death. Here, we review current knowledge on integrated molecular machinery describe how dysregulated involved cancer, neurodegeneration, tissue injury, inflammation, infection.
Language: Английский
Citations
2580
Nature, Journal Year: 2019, Volume and Issue: 575(7784), P. 693 - 698
Published: Oct. 21, 2019
Language: Английский
Citations
2388
Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 18(5), P. 280 - 296
Published: Jan. 29, 2021
Language: Английский
Citations
2034
Cancer Cell, Journal Year: 2019, Volume and Issue: 35(6), P. 830 - 849
Published: May 16, 2019
Language: Английский
Citations
1972
Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(7), P. 395 - 417
Published: March 23, 2020
Language: Английский
Citations
1942
Cell, Journal Year: 2022, Volume and Issue: 185(14), P. 2401 - 2421
Published: July 1, 2022
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified as distinct phenomenon and named decade ago. Ferroptosis has been implicated in broad set biological contexts, from development to aging, immunity, cancer. This review describes key regulators this within framework metabolism, ROS biology, iron biology. Key concepts major unanswered questions the ferroptosis field are highlighted. The next promises yield further breakthroughs mechanisms governing additional ways harnessing for therapeutic benefit.
Language: Английский
Citations
1726