Pulmonary neuroendocrine cells amplify allergic asthma responses

Science, Journal Year: 2018, Volume and Issue: 360(6393)

Published: March 29, 2018

Finding a role for PNECs in asthma Pulmonary neuroendocrine cells (PNECs) are rare cell type located airway and alveolar epithelia often contact with sensory nerve fibers. They have wide phylogenic distribution found even the relatively primitive lungs of amphibia reptiles, suggesting critical function. Sui et al. that mice lacking suppressed 2 (allergic) immune responses. were observed close proximity to group innate lymphoid (ILC2s) around branch points. The enhanced ILC2 activity by secreting CGRP (calcitonin gene-related peptide). also induced goblet-cell hyperplasia via neurotransmitter GABA (γ-aminobutyric acid). Interestingly, human patients increased PNEC numbers, potential therapeutic target treatment asthma. Science , this issue p. eaan8546

Language: Английский

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Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity

Immunity, Journal Year: 2018, Volume and Issue: 48(6), P. 1104 - 1117

Published: June 1, 2018

Language: Английский

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Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(4), P. 417 - 426

Published: March 5, 2018

Language: Английский

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Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 4, 2020

Throughout the gastrointestinal (GI) tract, a distinct mucus layer composed of highly glycosylated proteins called mucins plays essential roles in providing lubrication for passage food, participating cell signaling pathways and protecting host epithelium from commensal microorganisms invading pathogens, as well toxins other environmental irritants. These can be broadly classified into either secreted gel-forming mucins, those that provide structural backbone barrier, or transmembrane form glycocalyx covering underlying epithelial cells. Goblet cells dispersed among intestinal are chiefly responsible synthesis secretion within gut heavily influenced by interactions with immune system. Evidence both clinical animal studies have indicated several GI conditions, including inflammatory bowel disease (IBD), colorectal cancer, numerous enteric infections accompanied considerable changes mucin quality quantity. include, but not limited to, impaired goblet function, dysregulation altered post-translational modifications. The current review aims to highlight functional features production immunological regulation impact these key elements context barrier function defense inflammation.

Language: Английский

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β ₂ -adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses

Science, Journal Year: 2018, Volume and Issue: 359(6379), P. 1056 - 1061

Published: March 1, 2018

The type 2 inflammatory response is induced by various environmental and infectious stimuli. Although recent studies identified group innate lymphoid cells (ILC2s) as potent sources of cytokines, the molecular pathways controlling ILC2 responses are incompletely defined. Here we demonstrate that murine ILC2s express β2-adrenergic receptor (β2AR) colocalize with adrenergic neurons in intestine. β2AR deficiency resulted exaggerated inflammation intestinal lung tissues. Conversely, agonist treatment was associated impaired reduced vivo. Mechanistically, pathway a cell-intrinsic negative regulator through inhibition cell proliferation effector function. Collectively, these data provide first evidence neuronal-derived regulatory circuit limits ILC2-dependent inflammation.

Language: Английский

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Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity

Cell, Journal Year: 2019, Volume and Issue: 178(4), P. 919 - 932.e14

Published: July 25, 2019

Language: Английский

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Neuromodulation by the immune system: a focus on cytokines

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(8), P. 526 - 541

Published: March 1, 2021

Language: Английский

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Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases

Journal of Clinical Investigation, Journal Year: 2019, Volume and Issue: 129(4), P. 1493 - 1503

Published: March 10, 2019

A rapidly developing paradigm for modern health care is a proactive and individualized response to patients’ symptoms, combining precision diagnosis personalized treatment. Precision medicine becoming an overarching medical discipline that will require better understanding of biomarkers, phenotypes, endotypes, genotypes, regiotypes, theratypes diseases. The 100-year-old allergen-specific management allergic diseases has particularly contributed early awareness in medicine. Polyomics, big data, systems biology have demonstrated profound complexity dynamic variability disease between individuals, as well regions. Escalating costs together with questionable efficacy the current facilitated emergence endotype-driven approach. We describe here approach stratifies patients based on mechanisms optimize

Language: Английский

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Type 2 immunity: Expanding our view

Science Immunology, Journal Year: 2018, Volume and Issue: 3(25)

Published: July 6, 2018

This Review focuses on our evolving view of type 2 immunity that has been spurred in recent years by the discovery group innate lymphoid cells.

Language: Английский

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Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

Immunity, Journal Year: 2019, Volume and Issue: 51(4), P. 682 - 695.e6

Published: July 25, 2019

Language: Английский

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