The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms

Immunological Reviews, Journal Year: 2018, Volume and Issue: 286(1), P. 37 - 52

Published: Oct. 7, 2018

Summary Group 2 innate lymphoid cells ( ILC 2s) play critical roles in the induction of type inflammation, response to parasite infection, metabolic homeostasis, and tissue repair. These multifunctional 2s are tightly controlled by complex regulatory systems local microenvironment, disruption which may cause various health problems. This review summarizes up‐to‐date knowledge regarding positive negative regulators for based on their function signaling pathways, including activating cytokines IL ‐33, ‐25; MAPK , NF ‐κB pathways), co‐stimulatory ‐2, ‐7, ‐9, TSLP ; STAT 5, ‐4; 6, TNF superfamily; suppressive (type1 IFN s, ‐γ, ‐27; 1, ‐10, TGF ‐β), transdifferentiation ‐12; 4, ‐1β, ‐18), lipid mediators LTC LTD LTE PGD 2; Ca 2+ ‐ NFAT PGE 2, PGI AC / cAMP PKA LXA LTB 4), neuropeptides NMU VIP CGRP catecholamine, acetylcholine), sex hormones (androgen, estrogen), nutrients (butyrate; HDAC inhibitors, vitamins), cell‐to‐cell interactions ICOSL ICOS B7‐H6‐ NK p30, E‐cadherin‐ KLRG 1). comprehensive affords a better understanding network system 2s, providing impetus develop new treatment strategies 2‐related

Language: Английский

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Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology

Cell, Journal Year: 2018, Volume and Issue: 173(3), P. 554 - 567

Published: April 1, 2018

Language: Английский

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Immune cells and CNS physiology: Microglia and beyond

The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 216(1), P. 60 - 70

Published: Nov. 30, 2018

Recent advances have directed our knowledge of the immune system from a narrative “self” versus “nonself” to one in which function is critical for homeostasis organs throughout body. This also case with respect central nervous (CNS). CNS immunity exists segregated state, marked partition occurring between brain parenchyma and meningeal spaces. While patrolled by perivascular macrophages microglia, spaces are supplied diverse repertoire. In this review, we posit that such allows neuro–immune crosstalk be properly tuned. Convention may imply an ominous threat function; however, recent studies shown its presence instead steady hand directing optimal performance.

Language: Английский

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Functional interactions between innate lymphoid cells and adaptive immunity

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(10), P. 599 - 613

Published: July 26, 2019

Language: Английский

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Neuro-immune Interactions in the Tissues

Immunity, Journal Year: 2020, Volume and Issue: 52(3), P. 464 - 474

Published: March 1, 2020

Language: Английский

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