The lung microenvironment: an important regulator of tumour growth and metastasis

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 19(1), P. 9 - 31

Published: Dec. 10, 2018

Language: Английский

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Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

Cell, Journal Year: 2019, Volume and Issue: 176(5), P. 998 - 1013.e16

Published: Jan. 31, 2019

Language: Английский

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Toward personalized treatment approaches for non-small-cell lung cancer

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(8), P. 1345 - 1356

Published: Aug. 1, 2021

Language: Английский

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The emerging treatment landscape of targeted therapy in non-small-cell lung cancer

Signal Transduction and Targeted Therapy, Journal Year: 2019, Volume and Issue: 4(1)

Published: Dec. 17, 2019

Abstract Lung cancer is one of the most common in world. In 2018, there were over 2 million new cases lung and 1.7 deaths attributed to cancer. Targeted therapy has emerged as an important mean disease management for patients with non-small-cell (NSCLC). Herein, we review analyze recent literature, discuss targeting pathways ongoing clinical trials Chemotherapy no longer best available treatment all patients. Therapeutic decisions should be guided by understanding molecular features patient’s tumor tissues. The future gains will likely emerge from finding optimal ways combining targeted therapy, immunotherapy, chemotherapy.

Language: Английский

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Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

Cell, Journal Year: 2020, Volume and Issue: 182(1), P. 200 - 225.e35

Published: July 1, 2020

To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization 110 tumors 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, acetylproteomics. Multi-omics clustering revealed four subgroups defined by key driver mutations, country, gender. Proteomic phosphoproteomic data illuminated downstream copy number aberrations, somatic fusions identified vulnerabilities associated with events involving KRAS, EGFR, ALK. Immune subtyping a complex landscape, reinforced association STK11 immune-cold behavior, underscored potential immunosuppressive role neutrophil degranulation. Smoking-associated LUADs showed correlation other environmental exposure signatures field effect in NATs. Matched NATs allowed identification differentially expressed proteins diagnostic utility. This proteogenomics dataset represents unique public resource for researchers clinicians seeking to better understand treat adenocarcinomas.

Language: Английский

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Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 5, 2021

Abstract Lung cancer is a highly heterogeneous disease. Cancer cells and within the tumor microenvironment together determine disease progression, as well response to or escape from treatment. To map cell type-specific transcriptome landscape of their in advanced non-small lung (NSCLC), we analyze 42 tissue biopsy samples stage III/IV NSCLC patients by single RNA sequencing present large scale, resolution profiles NSCLCs. In addition types described previous studies early cancer, are able identify rare tumors such follicular dendritic T helper 17 cells. Tumors different display heterogeneity cellular composition, chromosomal structure, developmental trajectory, intercellular signaling network phenotype dominance. Our study also reveals correlation with associated neutrophils, which might help shed light on function NSCLC.

Language: Английский

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Integrative Proteomic Characterization of Human Lung Adenocarcinoma

Cell, Journal Year: 2020, Volume and Issue: 182(1), P. 245 - 261.e17

Published: July 1, 2020

Language: Английский

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circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 12, 2021

Abstract Circular RNAs (circRNA) are a class of covalently closed single-stranded that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated non-small cell lung (NSCLC) tissues, and negatively correlate with NSCLC malignant features. Elevated inhibits growth metastasis cells. Mechanistically, functions as scaffold enhance the interaction between TRIM25 IGF2BPs, positive regulator tumor progression metastasis. This TRIM25/circNDUFB2/IGF2BPs ternary complex facilitates ubiquitination degradation this effect enhanced by N 6 -methyladenosine (m A) modification . Moreover, is also recognized RIG-I activate RIG-I-MAVS signaling cascades recruit immune cells into microenvironment (TME). Our data thus provide evidences participates IGF2BPs activation anti-tumor immunity during via modulation both protein degradation, well cellular responses.

Language: Английский

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Current approaches to the management of brain metastases

Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(5), P. 279 - 299

Published: Feb. 20, 2020

Language: Английский

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Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives

Critical Reviews in Oncology/Hematology, Journal Year: 2020, Volume and Issue: 157, P. 103194 - 103194

Published: Dec. 11, 2020

Language: Английский

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