Top 10 Challenges in Cancer Immunotherapy

Immunity, Journal Year: 2020, Volume and Issue: 52(1), P. 17 - 35

Published: Jan. 1, 2020

Language: Английский

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The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 374 - 403

Published: March 1, 2023

Language: Английский

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Cancer immunoediting and resistance to T cell-based immunotherapy

Nature Reviews Clinical Oncology, Journal Year: 2018, Volume and Issue: 16(3), P. 151 - 167

Published: Dec. 6, 2018

Language: Английский

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Turning foes to friends: targeting cancer-associated fibroblasts

Nature Reviews Drug Discovery, Journal Year: 2018, Volume and Issue: 18(2), P. 99 - 115

Published: Nov. 23, 2018

Language: Английский

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Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: Oct. 11, 2021

Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote growth, angiogenesis, invasion metastasis, along extracellular matrix (ECM) remodeling even chemoresistance. Numerous previous studies have confirmed critical role interaction between cells in tumorigenesis development. However, recently, mutual effects immune (TIME) been identified as another key factor promoting progression. The TIME mainly consists distinct populations islets is highly associated antitumor immunological state TME. interact tumor-infiltrating well other within via secretion various cytokines, growth factors, chemokines, exosomes effector molecules, consequently shaping an immunosuppressive TME that enables cancer to evade surveillance system. In-depth interactions, particularly complicated mechanisms connecting cells, might provide novel strategies for subsequent targeted immunotherapies. Herein, we shed light on recent advances regarding direct indirect crosstalk infiltrating further summarize possible immunoinhibitory induced by In addition, present current related CAF-targeting immunotherapies briefly describe some future perspectives CAF research end.

Language: Английский

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Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(9), P. 1449 - 1458

Published: July 13, 2018

Language: Английский

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CD4+ T cell help in cancer immunology and immunotherapy

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(10), P. 635 - 647

Published: July 29, 2018

Language: Английский

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Tumour-intrinsic resistance to immune checkpoint blockade

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 20(1), P. 25 - 39

Published: Sept. 30, 2019

Language: Английский

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Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma

New England Journal of Medicine, Journal Year: 2020, Volume and Issue: 383(13), P. 1218 - 1230

Published: Sept. 18, 2020

Platinum-based chemotherapy is standard-of-care first-line treatment for advanced urothelial carcinoma. However, progression-free survival and overall are limited by resistance.

Language: Английский

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Therapeutic cancer vaccines

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(6), P. 360 - 378

Published: April 27, 2021

Language: Английский

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