Doublet identification in single-cell sequencing data using scDblFinder

F1000Research, Journal Year: 2021, Volume and Issue: 10, P. 979 - 979

Published: Sept. 28, 2021

Doublets are prevalent in single-cell sequencing data and can lead to artifactual findings. A number of strategies have therefore been proposed detect them. Building on the strengths existing approaches, we developed

Language: Английский

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Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

Cell, Journal Year: 2019, Volume and Issue: 176(6), P. 1325 - 1339.e22

Published: Feb. 28, 2019

Language: Английский

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The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Cell, Journal Year: 2020, Volume and Issue: 181(2), P. 236 - 249

Published: April 1, 2020

Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic ecosystem. Transformative single-cell genomics technologies spatial multiplex situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of National Cancer Institute (NCI) Moonshot Initiative, will establish a clinical, experimental, computational, organizational framework generate informative accessible three-dimensional atlases cancer for diverse set types. This effort complements both ongoing efforts map healthy organs previous large-scale approaches focused on bulk sequencing single point time. Generating single-cell, multiparametric, longitudinal integrating them with clinical outcomes should help identify novel predictive biomarkers features as well therapeutically relevant cell types, states, cellular across transitions. resulting have profound impact our understanding biology potential improve detection, prevention, discovery better precision-medicine treatments patients those risk cancer.

Language: Английский

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scGen predicts single-cell perturbation responses

Nature Methods, Journal Year: 2019, Volume and Issue: 16(8), P. 715 - 721

Published: July 29, 2019

Language: Английский

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Benchmarking single-cell RNA-sequencing protocols for cell atlas projects

Nature Biotechnology, Journal Year: 2020, Volume and Issue: 38(6), P. 747 - 755

Published: April 6, 2020

Language: Английский

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