Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Cellular Physiology and Biochemistry, Journal Year: 2015, Volume and Issue: 35(5), P. 1663 - 1676

Published: Jan. 1, 2015

Age-related macular degeneration (AMD) is the most common reason of visual impairment in elderly Western countries. The retinal pigment epithelial cells (RPE) causes secondarily adverse effects on neural retina leading to loss. aging characteristics RPE involve lysosomal accumulation lipofuscin and extracellular protein aggregates called "drusen". Molecular mechanisms behind aggregations are weakly understood. There intriguing evidence suggesting that SQSTM1/p62, together with autophagy, has a role pathology different degenerative diseases. It appears SQSTM1/p62 connecting link between autophagy proteasome mediated proteolysis, expressed strongly under exposure various oxidative stimuli proteasomal inhibition. ELAVL1/HuR post-transcriptional factor, which acts mainly as positive regulator gene expression by binding specific mRNAs whose corresponding proteins fundamental for key cellular functions. We here show that, inhibitor MG-132, up-regulated at both mRNA levels, this binds post-transcriptionally regulates ARPE-19 cell line. Furthermore, we observed inhibition caused bound irreversibly perinuclear aggregates. addition AMPK activator AICAR was pro-survival promoted cleansing former complex, but not accumulation, indeed decreased through autophagy-mediated degradation, while pathway. Interestingly, when compared human controls, AMD donor samples strong rather than drusen rich area impaired AMD.

Language: Английский

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AKT/PKB Signaling: Navigating the Network

Cell, Journal Year: 2017, Volume and Issue: 169(3), P. 381 - 405

Published: April 1, 2017

Language: Английский

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Mitochondria: In Sickness and in Health

Cell, Journal Year: 2012, Volume and Issue: 148(6), P. 1145 - 1159

Published: March 1, 2012

Language: Английский

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Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Circulation Research, Journal Year: 2018, Volume and Issue: 122(6), P. 877 - 902

Published: March 15, 2018

Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes subcellular compartments that typically produce ROS associated with metabolic regulation, diseases dysfunction may be influenced by changes redox balance. In this review, we summarize the current literature surrounding inflammatory focusing on transduction its relationship to disease progression. particular, examine production such as cytoplasm, mitochondria, peroxisome, endoplasmic reticulum discuss how influence processes proteasome function, autophagy, general signaling. We also highlight of regulation metabolic/inflammatory including atherosclerosis, diabetes mellitus, stroke. order develop therapies target oxidative signaling, it is vital understand balance signaling plays physiology pathophysiology, manipulation identity cellular tissue homeostasis. An increased understanding specific sources an appreciation metabolism help guide us effort treat cardiovascular diseases.

Language: Английский

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Ageing as a Risk Factor for Disease

Current Biology, Journal Year: 2012, Volume and Issue: 22(17), P. R741 - R752

Published: Sept. 1, 2012

Language: Английский

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Mechanisms of physiological and pathological cardiac hypertrophy

Nature Reviews Cardiology, Journal Year: 2018, Volume and Issue: 15(7), P. 387 - 407

Published: April 19, 2018

Language: Английский

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Cancer metabolism: fatty acid oxidation in the limelight

Nature reviews. Cancer, Journal Year: 2013, Volume and Issue: 13(4), P. 227 - 232

Published: Feb. 28, 2013

Language: Английский

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The Role of Estrogens in Control of Energy Balance and Glucose Homeostasis

Endocrine Reviews, Journal Year: 2013, Volume and Issue: 34(3), P. 309 - 338

Published: May 30, 2013

Estrogens play a fundamental role in the physiology of reproductive, cardiovascular, skeletal, and central nervous systems. In this report, we review literature both rodents humans on estrogens their receptors control energy homeostasis glucose metabolism health metabolic diseases. Estrogen actions hypothalamic nuclei differentially food intake, expenditure, white adipose tissue distribution. skeletal muscle, liver, tissue, immune cells are involved insulin sensitivity as well prevention lipid accumulation inflammation. pancreatic islet β-cells also regulate secretion, nutrient homeostasis, survival. deficiency promotes dysfunction predisposing to obesity, syndrome, type 2 diabetes. We discuss effect selective estrogen receptor modulators disorders.

Language: Английский

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Autophagy in malignant transformation and cancer progression

The EMBO Journal, Journal Year: 2015, Volume and Issue: 34(7), P. 856 - 880

Published: Feb. 23, 2015

Language: Английский

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Mitochondrial energetics in the kidney

Nature Reviews Nephrology, Journal Year: 2017, Volume and Issue: 13(10), P. 629 - 646

Published: Aug. 14, 2017

Language: Английский

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