Journal of Cell Science,
Journal Year:
2020,
Volume and Issue:
133(2)
Published: Jan. 15, 2020
ABSTRACT
YAP
and
TAZ
proteins
are
transcriptional
coactivators
encoded
by
paralogous
genes,
which
shuttle
between
the
cytoplasm
nucleus
in
response
to
multiple
inputs,
including
Hippo
pathway.
In
nucleus,
they
pair
with
DNA-binding
factors
of
TEAD
family
regulate
gene
expression.
Nuclear
YAP/TAZ
promote
cell
proliferation,
organ
overgrowth,
survival
stress
dedifferentiation
post-mitotic
cells
into
their
respective
tissue
progenitors.
required
for
growth
embryonic
tissues,
wound
healing
regeneration,
where
activated
cell-intrinsic
extrinsic
cues.
Surprisingly,
this
activity
is
dispensable
many
adult
self-renewing
constantly
kept
check.
lay
at
center
a
complex
regulatory
network
cell-autonomous
but
also
cell-
tissue-level
structural
features
such
as
mechanical
properties
microenvironment,
establishment
cell–cell
junctions
basolateral
polarity.
Enhanced
levels
observed
cancers,
sustain
tumor
growth,
drug
resistance
malignancy.
Cell
Science
Glance
article
accompanying
poster,
we
review
biological
functions
mechanisms,
highlight
position
signaling
network.
Genes & Development,
Journal Year:
2016,
Volume and Issue:
30(1), P. 1 - 17
Published: Jan. 1, 2016
The
Hippo
pathway
was
initially
identified
in
Drosophila
melanogaster
screens
for
tissue
growth
two
decades
ago
and
has
been
a
subject
extensively
studied
both
mammals
the
last
several
years.
core
of
consists
kinase
cascade,
transcription
coactivators,
DNA-binding
partners.
Recent
studies
have
expanded
as
complex
signaling
network
with
>30
components.
This
is
regulated
by
intrinsic
cell
machineries,
such
cell–cell
contact,
polarity,
actin
cytoskeleton,
well
wide
range
signals,
including
cellular
energy
status,
mechanical
cues,
hormonal
signals
that
act
through
G-protein-coupled
receptors.
major
functions
defined
to
restrict
adults
modulate
proliferation,
differentiation,
migration
developing
organs.
Furthermore,
dysregulation
leads
aberrant
neoplasia.
In
this
review,
we
focus
on
recent
developments
our
understanding
molecular
actions
cascade
discuss
key
open
questions
regulation
function
pathway.
Annual Review of Biochemistry,
Journal Year:
2018,
Volume and Issue:
88(1), P. 577 - 604
Published: Dec. 19, 2018
The
Hippo
pathway
was
initially
discovered
in
Drosophila
melanogaster
as
a
key
regulator
of
tissue
growth.
It
is
an
evolutionarily
conserved
signaling
cascade
regulating
numerous
biological
processes,
including
cell
growth
and
fate
decision,
organ
size
control,
regeneration.
core
the
mammals
consists
kinase
cascade,
MST1/2
LATS1/2,
well
downstream
effectors,
transcriptional
coactivators
YAP
TAZ.
These
components
control
programs
involved
proliferation,
survival,
mobility,
stemness,
differentiation.
tightly
regulated
by
both
intrinsic
extrinsic
signals,
such
mechanical
force,
cell-cell
contact,
polarity,
energy
status,
stress,
many
diffusible
hormonal
factors,
majority
which
act
through
G
protein-coupled
receptors.
Here,
we
review
current
understanding
molecular
mechanisms
signals
regulate
with
emphasis
on
mechanotransduction
effects
this
basic
biology
human
diseases.
