Ferroptosis: mechanisms, biology and role in disease

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(4), P. 266 - 282

Published: Jan. 25, 2021

Language: Английский

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EMT Transition States during Tumor Progression and Metastasis

Trends in Cell Biology, Journal Year: 2018, Volume and Issue: 29(3), P. 212 - 226

Published: Dec. 26, 2018

Language: Английский

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Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

Cell, Journal Year: 2015, Volume and Issue: 163(4), P. 811 - 828

Published: Nov. 1, 2015

Language: Английский

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YAP/TAZ at the Roots of Cancer

Cancer Cell, Journal Year: 2016, Volume and Issue: 29(6), P. 783 - 803

Published: June 1, 2016

Language: Английский

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Mechanisms of Hippo pathway regulation

Genes & Development, Journal Year: 2016, Volume and Issue: 30(1), P. 1 - 17

Published: Jan. 1, 2016

The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied both mammals the last several years. core of consists kinase cascade, transcription coactivators, DNA-binding partners. Recent studies have expanded as complex signaling network with >30 components. This is regulated by intrinsic cell machineries, such cell–cell contact, polarity, actin cytoskeleton, well wide range signals, including cellular energy status, mechanical cues, hormonal signals that act through G-protein-coupled receptors. major functions defined to restrict adults modulate proliferation, differentiation, migration developing organs. Furthermore, dysregulation leads aberrant neoplasia. In this review, we focus on recent developments our understanding molecular actions cascade discuss key open questions regulation function pathway.

Language: Английский

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Mechanobiology of YAP and TAZ in physiology and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(12), P. 758 - 770

Published: Sept. 27, 2017

Language: Английский

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The Hippo Pathway: Biology and Pathophysiology

Annual Review of Biochemistry, Journal Year: 2018, Volume and Issue: 88(1), P. 577 - 604

Published: Dec. 19, 2018

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control, regeneration. core the mammals consists kinase cascade, MST1/2 LATS1/2, well downstream effectors, transcriptional coactivators YAP TAZ. These components control programs involved proliferation, survival, mobility, stemness, differentiation. tightly regulated by both intrinsic extrinsic signals, such mechanical force, cell-cell contact, polarity, energy status, stress, many diffusible hormonal factors, majority which act through G protein-coupled receptors. Here, we review current understanding molecular mechanisms signals regulate with emphasis on mechanotransduction effects this basic biology human diseases.

Language: Английский

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Integrin-mediated mechanotransduction

The Journal of Cell Biology, Journal Year: 2016, Volume and Issue: 215(4), P. 445 - 456

Published: Nov. 8, 2016

Cells can detect and react to the biophysical properties of extracellular environment through integrin-based adhesion sites adapt milieu in a process called mechanotransduction. At these sites, integrins connect matrix (ECM) with F-actin cytoskeleton transduce mechanical forces generated by actin retrograde flow myosin II ECM mechanosensitive focal proteins that are collectively termed “molecular clutch.” The transmission across adhesions establishes reciprocity between viscoelasticity cellular tension. During mechanotransduction, force allosterically alters functions within elicit biochemical signals regulate both rapid responses mechanics long-term changes gene expression. Integrin-mediated mechanotransduction plays important roles development tissue homeostasis, its dysregulation is often associated diseases.

Language: Английский

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YAP/TAZ upstream signals and downstream responses

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(8), P. 888 - 899

Published: July 19, 2018

Language: Английский

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Cellular Mechanotransduction: From Tension to Function

Frontiers in Physiology, Journal Year: 2018, Volume and Issue: 9

Published: July 5, 2018

Living cells are constantly exposed to mechanical stimuli arising from the surrounding extracellular matrix (ECM) or neighboring cells. The intracellular molecular processes through which such physical cues transformed into a biological response collectively dubbed as mechanotransduction and of fundamental importance help cell timely adapt continuous dynamic modifications microenvironment. Local changes in ECM composition mechanics driven by feed forward interplay between itself, with first depositing proteins that turn will impact on As such, these occur regularly during tissue development hallmark pathologies aging. Only lately, though, controlling function (e.g., proliferation, differentiation, migration) has been acknowledged. Here we provide critical review recent insights basis cellular mechanotransduction, analyzing how get given activation peculiar genetic program. Specifically, recapitulating involved interpretation remodeling Focal Adhesions at cell-matrix interphase, revise role cytoskeleton tension second messenger process action mechano-responsive shuttling converging stage cell-specific transcription factors. Finally, give few paradigmatic examples highlighting emerging malfunctions mechanosensing apparatus onset progression pathologies.

Language: Английский

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