Glutamine reliance in cell metabolism

Experimental & Molecular Medicine, Journal Year: 2020, Volume and Issue: 52(9), P. 1496 - 1516

Published: Sept. 1, 2020

Abstract As knowledge of cell metabolism has advanced, glutamine been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence drug resistance, glutaminolysis-induced reprogramming presenting strategies target in cancer cells. In this review, we introduce various biosynthetic bioenergetic roles based compartmentalization explain why cells exhibit reliance glutamine. Additionally, examined whether derivatives contribute epigenetic regulation associated with tumorigenesis. addition, discussing transporters, propose for therapeutic intervention cancer.

Language: Английский

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Metabolism of immune cells in cancer

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(9), P. 516 - 531

Published: July 6, 2020

Language: Английский

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Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

Cell, Journal Year: 2018, Volume and Issue: 175(7), P. 1780 - 1795.e19

Published: Nov. 1, 2018

Language: Английский

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Modulation of cellular processes by histone and non-histone protein acetylation

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(5), P. 329 - 349

Published: Jan. 18, 2022

Language: Английский

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Metabolomics in cancer research and emerging applications in clinical oncology

CA A Cancer Journal for Clinicians, Journal Year: 2021, Volume and Issue: 71(4), P. 333 - 358

Published: May 13, 2021

Abstract Cancer has myriad effects on metabolism that include both rewiring of intracellular to enable cancer cells proliferate inappropriately and adapt the tumor microenvironment, changes in normal tissue metabolism. With recognition fluorodeoxyglucose‐positron emission tomography imaging is an important tool for management many cancers, other metabolites biological samples have been spotlight diagnosis, monitoring, therapy. Metabolomics global analysis small molecule like ‐omics technologies can provide critical information about state are otherwise not apparent. Here, authors review how therapies interact with at cellular systemic levels. An overview metabolomics provided a focus currently available they applied clinical translational research setting. The also discuss could be further leveraged future improve patients cancer.

Language: Английский

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Metabolic reprogramming and epigenetic modifications on the path to cancer

Protein & Cell, Journal Year: 2021, Volume and Issue: 13(12), P. 877 - 919

Published: May 29, 2021

Abstract Metabolic rewiring and epigenetic remodeling, which are closely linked reciprocally regulate each other, among the well-known cancer hallmarks. Recent evidence suggests that many metabolites serve as substrates or cofactors of chromatin-modifying enzymes a consequence translocation spatial regionalization metabolites. Various metabolic alterations modifications also reportedly drive immune escape impede immunosurveillance within certain contexts, playing important roles in tumor progression. In this review, we focus on how reprogramming cells reshapes alterations, particular acetylation methylation histone proteins DNA. We discuss other eminent such as, succinylation, hydroxybutyrylation, lactylation, update current advances metabolism- modification-based therapeutic prospects cancer.

Language: Английский

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Glycolysis – a key player in the inflammatory response

FEBS Journal, Journal Year: 2020, Volume and Issue: 287(16), P. 3350 - 3369

Published: April 7, 2020

The inflammatory response involves the activation of several cell types to fight insults caused by a plethora agents, and maintain tissue homoeostasis. On one hand, cells involved in pro‐inflammatory response, such as M1 macrophages, Th1 Th17 lymphocytes or activated microglia, must rapidly provide energy fuel inflammation, which is essentially accomplished glycolysis high lactate production. other regulatory T M2 are immune regulation resolution preferentially use fatty acid oxidation through TCA cycle main source for Here, we discuss impact glycolytic metabolism at different steps response. Finally, review wide variety molecular mechanisms could explain relationship between metabolites phenotype, including signalling events, epigenetic remodelling, post‐transcriptional post‐translational modifications. Inflammatory processes common feature many age‐associated diseases, cardiovascular neurodegenerative disorders. finding that immunometabolism be master regulator inflammation broadens avenue treating inflammation‐related pathologies manipulation vascular metabolism.

Language: Английский

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The evolving metabolic landscape of chromatin biology and epigenetics

Nature Reviews Genetics, Journal Year: 2020, Volume and Issue: 21(12), P. 737 - 753

Published: Sept. 9, 2020

Language: Английский

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The language of chromatin modification in human cancers

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(7), P. 413 - 430

Published: May 17, 2021

Language: Английский

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Metabolic signatures of cancer cells and stem cells

Nature Metabolism, Journal Year: 2019, Volume and Issue: 1(2), P. 177 - 188

Published: Feb. 11, 2019

Language: Английский

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