Seasonality of brain function: role in psychiatric disorders

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 22, 2023

Abstract Seasonality patterns are reported in various psychiatric disorders. The current paper summarizes findings on brain adaptations associated with seasonal changes, factors that contribute to individual differences and their implications for Changes circadian rhythms likely prominently mediate these effects since light strongly entrains the internal clock modifying function. Inability of accommodate changes might increase risk mood behavior problems as well worse clinical outcomes Understanding mechanisms account inter-individual variations seasonality is relevant development individualized prevention treatment Despite promising findings, still understudied only controlled a covariate most research. Rigorous neuroimaging studies thoughtful experimental designs, powered sample sizes high temporal resolution alongside deep characterization environment needed better understand adaptions human function age, sex, geographic latitude investigate underlying alterations adaptation

Language: Английский

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Influence of electromagnetic fields on the circadian rhythm: Implications for human health and disease

Biomedical Journal, Journal Year: 2023, Volume and Issue: 46(1), P. 48 - 59

Published: Jan. 19, 2023

Living organisms have evolved within the natural electromagnetic fields (EMFs) of earth which comprise global atmospheric electrical circuit, Schumann resonances (SRs) and geomagnetic field. Research suggests that circadian rhythm, controls several physiological functions in human body, can be influenced by light but also earth's EMFs. Cyclic solar disturbances, including sunspots seasonal weakening field, affect health, possibly disrupting rhythm downstream functions. Severe disruption increases inflammation induce fatigue, fever flu-like symptoms a fraction population worsen existing old diseased individuals, leading to periodic spikes infectious chronic diseases. Possible mechanisms underlying sensing EMFs involve entrainment via electrons waves, light-dependent radical pair formation retina cryptochromes, paramagnetic magnetite nanoparticles. Factors such as pollution from wireless devices, base antennas low orbit internet satellites, shielding non-conductive materials used shoes buildings, local anomalies may body contribute disease development.

Language: Английский

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Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2015, Volume and Issue: 100(9), P. E1255 - E1261

Published: July 13, 2015

Context: Shift workers are at increased risk of metabolic morbidities. Clock genes known to regulate processes in peripheral tissues, eg, glucose oxidation. Objective: This study aimed investigate how clock affected the epigenetic and transcriptional level human tissues following acute total sleep deprivation (TSD), mimicking shift work with extended wakefulness. Intervention: In a randomized, two-period, two-condition, crossover clinical study, 15 healthy men underwent two experimental sessions: x (2230–0700 h) overnight On subsequent morning, serum cortisol was measured, followed by skeletal muscle subcutaneous adipose tissue biopsies for DNA methylation gene expression analyses core (BMAL1, CLOCK, CRY1, PER1). Finally, baseline 2-h post-oral load plasma concentrations were determined. Main Outcome Measures: tissue, vs promoter CRY1 (+4%; P = .026) promoter-interacting enhancer regions PER1 (+15%; .036; +9%; .026). muscle, TSD decreased BMAL1 (−18%; .033) (−22%; .047). Concentrations cortisol, which can reset clocks, (2449 ± 932 3178 723 nmol/L; .039), whereas postprandial elevated after (7.77 1.63 6.59 1.32 mmol/L; .011). Conclusions: Our findings demonstrate that single night wakefulness alter profile circadian key tissues. Tissue-specific alterations could explain why may disrupt integrity as observed herein.

Language: Английский

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Disrupted seasonal biology impacts health, food security and ecosystems

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2015, Volume and Issue: 282(1817), P. 20151453 - 20151453

Published: Oct. 15, 2015

The rhythm of life on earth is shaped by seasonal changes in the environment. Plants and animals show profound annual cycles physiology, health, morphology, behaviour demography response to environmental cues. Seasonal biology impacts ecosystems agriculture, with consequences for humans biodiversity. Human populations robust rhythms health well-being, birth month can have lasting effects that persist throughout life. This review emphasizes need a better understanding against backdrop its rapidly progressing disruption through climate change, human lifestyles other anthropogenic impact. Climate change modifying which numerous organisms adapted, potential industries relating food security. Disconcertingly, under artificial conditions eternal summer provide most extreme example disconnect from natural seasons, making vulnerable increased morbidity mortality. In this review, we introduce scenarios disruption, highlight key aspects summarize biomedical, anthropological, veterinary, agricultural perspectives recent evidence desynchronization between factors internal rhythms. Because are pervasive across biological systems, they common framework trans-disciplinary research.

Language: Английский

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Annual transcriptome dynamics in natural environments reveals plant seasonal adaptation

Nature Plants, Journal Year: 2018, Volume and Issue: 5(1), P. 74 - 83

Published: Dec. 20, 2018

Language: Английский

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