Frontiers in Physiology,
Journal Year:
2017,
Volume and Issue:
8
Published: March 21, 2017
Excessive
consumption
of
diets
high
in
sugars
and
saturated
fat,
frequently
known
as
western
diet
(WD),
may
lead
to
obesity
metabolic
syndrome.
Recent
evidence
shows
that
WD-induced
impairs
cardiac
function,
but
the
underlying
mechanisms
are
not
fully
understood.
Trimethylamine
N-oxide
(TMAO),
a
gut
microbiota-dependent
metabolite
specific
dietary
nutrients,
has
emerged
key
contributor
cardiovascular
disease
pathogenesis.
We
tested
hypothesis
elevated
circulating
TMAO
levels
contribute
dysfunction
obesity.
CD1
mice
were
fed
normal
(ND)
or
WD,
without
with
1.0%
3,3-Dimethyl-1-butanol
(DMB,
an
inhibitor
trimethylamine
formation)
drinking
water
for
8
weeks.
Compared
ND,
WD
showed
significant
increase
body
weight
dyslipidemia,
had
markedly
higher
plasma
at
end
feeding
protocol.
Echocardiography
revealed
systolic
diastolic
function
was
impaired
WD.
DMB
treatment
no
effects
on
significantly
reduced
prevented
In
addition,
expression
pro-inflammatory
cytokines
tumor
necrosis
factor-α
interleukin
IL-1β,
decreased
anti-inflammatory
cytokine
IL-10,
increased
interstitial
fibrosis
hearts,
all
which
by
treatment.
Notably,
also
ND
did
alter
other
parameters.
These
results
suggest
increases
levels,
inflammation
fibrosis,
contributing
dysfunction.
Interventions
reduce
be
novel
therapeutic
strategy
prevention
Frontiers in Pharmacology,
Journal Year:
2018,
Volume and Issue:
9
Published: Nov. 23, 2018
As
an
important
source
for
traditional
medical
systems
such
as
Ayurvedic
medicine
and
Chinese
medicine,
herbal
medicines
have
received
a
lot
of
attention
all
over
the
world,
especially
in
developing
countries.
Over
past
decade,
studies
on
gut
microbiota
generated
rich
information
understanding
how
shape
functioning
our
body
system.
In
view
importance
microbiota,
researchers
engaged
studying
paid
more
to
metabolites.
Of
variety
metabolites,
short-chain
fatty
acids
(SCFAs)
most
because
their
role
maintaining
hemostasis
hosts
recovery
diseases.
Herbal
medicines,
resource
provider
production
SCFAs,
been
demonstrated
be
able
modulate
composition
regulate
SCFAs
production.
this
mini-review,
we
summarize
current
knowledge
about
origination,
health
disease,
influence
corresponding
mechanisms.
At
end
review,
strategies
suggestions
further
research
are
also
discussed.
Journal of Food and Drug Analysis,
Journal Year:
2019,
Volume and Issue:
27(3), P. 615 - 622
Published: Feb. 2, 2019
Studies
on
the
role
of
gut
commensal
bacteria
in
health
development
have
rapidly
attracted
much
more
attention
beyond
classical
pathogens
over
last
decade.
Many
important
reports
highlighted
changes
microbiota
(dysbiosis)
are
closely
related
to
intra-
and
extra-intestinal,
chronic
inflammation
diseases
such
as
colitis,
obesity/metabolic
syndromes,
diabetes
mellitus,
liver
diseases,
cardiovascular
also
cancer
neurodegenerative
diseases.
To
circumvent
these
difficulties,
strategy
modulating
structure
has
been
under
intensive
study
shed
light
amelioration
While
traditional
probiotics
generally
show
marginal
ameliorative
effects,
emerging
next
generation
start
reveal
new
preventive
therapeutic
tools.
Recent
studies
unraveled
many
potential
(NGP).
These
include
Prevotella
copri
Christensenella
minuta
that
control
insulin
resistance,
Parabacteroides
goldsteinii,
Akkermansia
muciniphila
Bacteroides
thetaiotaomicron
reverse
obesity
Faecalibacterium
prausnitzii
protects
mice
against
intestinal
fragilis
reduces
shows
anticancer
effect.
New
agents
will
soon
be
revealed
for
targeted
therapy
specific
The
roles
normobiosis
maintenance
integrity
homeostasis
emphasized.
Food & Function,
Journal Year:
2016,
Volume and Issue:
7(7), P. 3224 - 3232
Published: Jan. 1, 2016
Recently,
fucoidan
has
been
proposed
as
a
potential
prebiotic
agent
for
functional
food
and
pharmaceutical
development.
However,
while
previous
studies
illustrated
favorable
modulations
of
gut
microbiota
by
fucoidan,
changes
in
the
overall
microbial
structure
remain
elusive.
In
present
study,
different
fucoidans
were
studied
using
high
throughput
sequencing
bioinformatics
analysis.
We
found
that
at
expense
opportunistic
pathogenic
bacteria
such
Peptococcus,
abundance
beneficial
including
Lactobacillus
Ruminococcaceae
was
significantly
increased
response
to
treatment.
Besides,
maintaining
more
balanced
composition
microbiota,
dietary
also
reduced
antigen
load
inflammatory
host
evidenced
decreased
serum
lipopolysaccharide-binding
protein
levels.
Collectively,
our
results
indicate
can
be
used
modulator
health
promotion
treatment
intestinal
dysbiosis.
Medicinal Research Reviews,
Journal Year:
2017,
Volume and Issue:
37(5), P. 1140 - 1185
Published: Jan. 4, 2017
Herbal
medicines
(HMs)
are
much
appreciated
for
their
significant
contribution
to
human
survival
and
reproduction
by
remedial
prophylactic
management
of
diseases.
Defining
the
scientific
basis
HMs
will
substantiate
value
promote
modernization.
Ever-increasing
evidence
suggests
that
gut
microbiota
plays
a
crucial
role
in
HM
therapy
complicated
interplay
with
components.
This
includes
such
activities
as:
biotransforming
chemicals
into
metabolites
harbor
different
bioavailability
bioactivity/toxicity
from
precursors;
improving
composition
microbiota,
consequently
ameliorating
its
dysfunction
as
well
associated
pathological
conditions;
mediating
interactions
(synergistic
antagonistic)
between
multiple
HMs.
More
advanced
experimental
designs
recommended
future
study,
overall
chemical
characterization
microbiota-metabolized
HMs,
direct
microbial
analysis
HM-targeted
precise
research
model
development.
The
outcomes
can
further
elucidate
thereby
opening
new
window
defining
guiding
HM-based
drug
discovery.
Theranostics,
Journal Year:
2020,
Volume and Issue:
10(23), P. 10665 - 10679
Published: Jan. 1, 2020
Background:
Gut
microbiota,
which
plays
a
crucial
role
in
inflammatory
bowel
diseases
(IBD),
might
have
therapeutic
benefits
for
ulcerative
colitis
or
Crohn's
disease.
Targeting
gut
microbiota
represents
new
treatment
strategy
IBD
patients.
Rhein
is
one
of
the
main
components
rhubarb
and
exhibits
poor
oral
bioavailability
but
still
exerts
anti-inflammatory
effects
some
diseases.
Therefore,
we
investigated
effect
rhein
on
studied
its
possible
mechanisms.
Methods:
The
chronic
mouse
model
was
induced
by
four
rounds
2%
dextran
sulfate
sodium
(DSS)
treatment.
mice
were
treated
with
50
mg/kg
100
daily,
body
weight,
colon
length,
histological
score,
cytokines
serum
intestine,
fecal
lipocalin
2
concentration
determined.
Th17
cell,
Th1
cell
Th2
infiltration
mesenteric
lymph
node
analyzed
flow
cytometry.
Metabolic
profiles
collected
non-targeted
metabolomics
key
metabolic
pathways
identified
using
MetaboAnalyst
4.0.
We
also
assessed
intestinal
barrier
permeability
performed
16s
rDNA
sequencing.
Lactobacillus
sp.
cultured,
transplantation
(FMT)
employed
to
evaluate
contribution
microbiota.
Results:
could
significantly
alleviate
DSS-induced
colitis.
Uric
acid
as
modulator
led
decreased
uric
levels.
determined
that
changed
purine
metabolism
indirectly,
while
probiotic
involved
regulation
host
metabolism.
resulted
worsened
barrier,
be
rescued
rhein.
further
confirmed
rhein-treated
sufficient
relieve
FMT.
Conclusion:
showed
modulate
indirectly
intestine
subsequently
alleviated
Our
study
has
approach
clinical
