Heart Disease and Stroke Statistics—2021 Update

Circulation, Journal Year: 2021, Volume and Issue: 143(8)

Published: Jan. 27, 2021

The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs).The through its Statistics Committee, continuously monitors evaluates sources stroke United States provide current information available annual Update. 2021 is product full year's worth effort by dedicated volunteer clinicians scientists, committed government professionals, Association staff members. This edition includes monitoring benefits population, an enhanced focus social determinants health, adverse pregnancy outcomes, vascular contributions brain global burden further evidence-based approaches changing disease.Each 27 chapters focuses different topic statistics.The represents critical resource for lay public, policy makers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.

Language: Английский

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Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Circulation, Journal Year: 2022, Volume and Issue: 145(8)

Published: Jan. 26, 2022

The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs).

Language: Английский

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Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Circulation, Journal Year: 2023, Volume and Issue: 147(8)

Published: Jan. 25, 2023

Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs). Methods: through its Epidemiology Prevention Statistics Committee, continuously monitors evaluates sources stroke United States provide current information available annual review published literature year before writing. 2023 is product full year’s worth effort 2022 by dedicated volunteer clinicians scientists, committed government professionals, Association staff members. strives further understand help heal problems inflicted structural racism, public crisis can significantly damage mental perpetuate disparities access education, income, housing, several other vital healthy lives. This edition includes additional COVID-19 (coronavirus 2019) publications, as well monitoring benefits population, an enhanced focus equity across key domains. Results: Each chapters focuses different topic statistics. Conclusions: represents critical resource for lay public, policymakers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.

Language: Английский

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Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

Cell, Journal Year: 2020, Volume and Issue: 180(3), P. 568 - 584.e23

Published: Jan. 23, 2020

Language: Английский

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2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Circulation, Journal Year: 2024, Volume and Issue: 149(8)

Published: Jan. 24, 2024

BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, obesity) factors (cholesterol, blood pressure, glucose control, metabolic syndrome) that contribute health. AHA Disease Stroke Statistical Update presents latest data on a range major clinical circulatory disease conditions (including brain health, complications pregnancy, kidney congenital rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary cardiomyopathy, failure, valvular venous thromboembolism, peripheral artery disease) associated outcomes quality care, procedures, economic costs). METHODS: AHA, through its Epidemiology Prevention Statistics Committee, continuously monitors evaluates sources stroke United States globally provide current information available annual review published literature year before writing. 2024 is product full year’s worth effort 2023 by dedicated volunteer clinicians scientists, committed government professionals, staff members. strives further understand help heal problems inflicted structural racism, public crisis can significantly damage mental perpetuate disparities access education, income, housing, several other vital healthy lives. This edition includes additional global data, as well monitoring benefits population, an enhanced focus equity across key domains. RESULTS: Each chapters focuses different topic statistics. CONCLUSIONS: represents critical resource for lay public, policymakers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.

Language: Английский

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Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

Nature Genetics, Journal Year: 2018, Volume and Issue: 50(9), P. 1234 - 1239

Published: July 26, 2018

Language: Английский

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Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association

Circulation, Journal Year: 2018, Volume and Issue: 138(21)

Published: Oct. 16, 2018

This review provides an updated summary of the state our knowledge genetic contributions to pathogenesis congenital heart disease. Since 2007, when initial American Heart Association scientific statement on basis disease was published, new genomic techniques have become widely available that dramatically changed understanding causes and, clinically, allowed more accurate definition pathogeneses in patients all ages and even prenatally. Information is presented molecular testing their application disease, both isolated associated with other anomalies or syndromes. Recent advances copy number variants, syndromes, RASopathies, heterotaxy/ciliopathies are provided. Insights into research models, including genetically manipulated animals such as mice, chicks, zebrafish, well human induced pluripotent stem cell-based approaches provided allow how future breakthroughs for likely happen. It anticipated this will provide a large range health care-related personnel, pediatric cardiologists, pediatricians, adult thoracic surgeons, obstetricians, geneticists, counselors, related clinicians, timely information aspects The objective comprehensive interdisciplinary care those

Language: Английский

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Variant interpretation using population databases: Lessons from gnomAD

Human Mutation, Journal Year: 2021, Volume and Issue: 43(8), P. 1012 - 1030

Published: Dec. 3, 2021

Reference population databases are an essential tool in variant and gene interpretation. Their use guides the identification of pathogenic variants amidst sea benign variation present every human genome, supports discovery new disease–gene relationships. The Genome Aggregation Database (gnomAD) is currently largest most widely used publicly available collection from harmonized sequencing data. data through online gnomAD browser (https://gnomad.broadinstitute.org/) that enables rapid intuitive analysis. This review provides guidance on content browser, its usage for We introduce key features including allele frequency, per-base expression levels, constraint scores, co-occurrence, alongside how to these analysis, with a focus interpretation candidate novel genes rare disease.

Language: Английский

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Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder

Science, Journal Year: 2018, Volume and Issue: 362(6420)

Published: Dec. 14, 2018

INTRODUCTION The DNA of protein-coding genes is transcribed into mRNA, which translated proteins. “coding genome” describes the that contains information to make these proteins and represents ~1.5% human genome. Newly arising de novo mutations (variants observed in a child but not either parent) coding genome contribute numerous childhood developmental disorders, including autism spectrum disorder (ASD). Discovery effects aided by triplet code enables functional impact many be readily deciphered. In contrast, “noncoding covers remaining ~98.5% includes elements regulate when, where, what degree are transcribed. Understanding this noncoding sequence could provide insights disorders refined control emerging genetic therapies. Yet little known about role regions, whether they most vulnerable disruption, manner encoded RATIONALE Whole-genome sequencing (WGS) provides opportunity identify majority variation each individual. By performing WGS on 1902 quartet families affected with ASD, one unaffected sibling control, their parents, we identified ~67 across child’s To characterize mutations, integrated multiple datasets relating gene function, implicated neurodevelopmental conservation species, epigenetic markers, thereby combinatorially defining 55,143 categories. scope problem—testing for an excess cases relative controls category—is challenging because there more categories than families. RESULTS Comparing controls, individual overcome challenge detecting association, used machine learning tools develop risk score look This demonstrated contribution ASD from weaker, significant, mutations. signal was driven promoter region, defined as 2000 nucleotides upstream transcription start site (TSS) where mRNA synthesis starts. strongest signals were species factor binding sites. Well-defined (e.g., TATA-box) usually within 80 TSS; however, association distally, 750 TSS. CONCLUSION We conclude ASD. clearest evidence came at evolutionarily conserved region. enrichment sites, primarily distal promoter, suggests may disrupt via interaction enhancer rather interfering transcriptional initiation directly. Promoter regions autism. De assigned annotation categories, assessed (ASD) comparing mutation counts controls. A especially sites or targeted factors.

Language: Английский

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Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model

Cell, Journal Year: 2018, Volume and Issue: 173(7), P. 1573 - 1580

Published: June 1, 2018

Language: Английский

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