Biophysical Journal,
Journal Year:
2013,
Volume and Issue:
105(3), P. 609 - 619
Published: Aug. 1, 2013
In
eukaryotic
cells,
small
changes
in
cell
volume
can
serve
as
important
signals
for
proliferation,
death,
and
migration.
Volume
shape
regulation
also
directly
impacts
the
mechanics
of
cells
tissues.
Here,
we
develop
a
mathematical
model
cellular
pressure
regulation,
incorporating
essential
elements
such
water
permeation,
mechanosensitive
channels,
active
ion
pumps,
stresses
cortex.
The
fully
explain
recent
experimental
data,
it
predicts
several
models
cortical
mechanics.
Moreover,
show
that
when
are
subjected
to
an
externally
applied
load,
atomic
force
microscopy
indentation
experiment,
leads
complex
response.
Instead
passive
cortex,
observed
stiffness
depends
on
factors
working
together.
This
provides
explanation
rate-dependent
response
under
force.
Developmental Cell,
Journal Year:
2022,
Volume and Issue:
57(4), P. 466 - 479.e6
Published: Feb. 1, 2022
The
cytoplasm
is
a
crowded,
visco-elastic
environment
whose
physical
properties
change
according
to
physiological
or
developmental
states.
How
the
of
impact
cellular
functions
in
vivo
remains
poorly
understood.
Here,
we
probe
effects
cytoplasmic
concentration
on
microtubules
by
applying
osmotic
shifts
fission
yeast,
moss,
and
mammalian
cells.
We
show
that
rates
both
microtubule
polymerization
depolymerization
scale
linearly
inversely
with
concentration;
an
increase
decreases
proportionally,
whereas
decrease
leads
opposite.
Numerous
lines
evidence
indicate
these
are
due
changes
viscosity
rather
than
stress
responses
macromolecular
crowding
per
se.
reconstituted
vitro
tuning
viscosity.
Our
findings
that,
even
normal
conditions,
modulates
reactions
underlie
dynamic
behaviors.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(21)
Published: Nov. 29, 2022
Abstract
Emerging
as
a
potent
anticancer
treatment,
subcellular
targeted
cancer
therapy
has
drawn
increasing
attention,
bringing
great
opportunities
for
clinical
application.
Here,
two
targeting
strategies
four
main
organelles
(mitochondria,
lysosome,
endoplasmic
reticulum,
and
nucleus),
including
molecule‐
nanomaterial
(inorganic
nanoparticles,
micelles,
organic
polymers,
others)‐based
delivery
or
therapeutic
strategies,
are
summarized.
Phototherapy,
chemotherapy,
radiotherapy,
immunotherapy,
“all‐in‐one”
combination
among
the
covered
in
detail.
Such
materials
constructed
based
on
specific
properties
relevant
mechanisms
of
organelles,
enabling
elimination
tumors
by
inducing
dysfunction
corresponding
destroying
structures.
The
challenges
faced
organelle‐targeting
therapies
also
Looking
forward,
paradigm
with
enhanced
efficacy
compared
to
current
approaches
is
envisioned.
Annual Review of Biophysics,
Journal Year:
2024,
Volume and Issue:
53(1), P. 367 - 395
Published: Feb. 21, 2024
The
mechanical
phenotype
of
a
cell
determines
its
ability
to
deform
under
force
and
is
therefore
relevant
cellular
functions
that
require
changes
in
shape,
such
as
migration
or
circulation
through
the
microvasculature.
On
practical
level,
can
be
used
global
readout
cell's
functional
state,
marker
for
disease
diagnostics,
an
input
tissue
modeling.
We
focus
our
review
on
current
knowledge
structural
components
contribute
determination
properties
highlight
physiological
processes
which
cells
critical
relevance.
ongoing
efforts
understand
how
efficiently
measure
control
will
define
progress
field
drive
phenotyping
toward
clinical
applications.
Biophysical Journal,
Journal Year:
2013,
Volume and Issue:
105(3), P. 609 - 619
Published: Aug. 1, 2013
In
eukaryotic
cells,
small
changes
in
cell
volume
can
serve
as
important
signals
for
proliferation,
death,
and
migration.
Volume
shape
regulation
also
directly
impacts
the
mechanics
of
cells
tissues.
Here,
we
develop
a
mathematical
model
cellular
pressure
regulation,
incorporating
essential
elements
such
water
permeation,
mechanosensitive
channels,
active
ion
pumps,
stresses
cortex.
The
fully
explain
recent
experimental
data,
it
predicts
several
models
cortical
mechanics.
Moreover,
show
that
when
are
subjected
to
an
externally
applied
load,
atomic
force
microscopy
indentation
experiment,
leads
complex
response.
Instead
passive
cortex,
observed
stiffness
depends
on
factors
working
together.
This
provides
explanation
rate-dependent
response
under
force.
