The microbiota-gut-brain axis in sleep disorders

Sleep Medicine Reviews, Journal Year: 2022, Volume and Issue: 65, P. 101691 - 101691

Published: Aug. 31, 2022

Language: Английский

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Hyperexcitable arousal circuits drive sleep instability during aging

Science, Journal Year: 2022, Volume and Issue: 375(6583)

Published: Feb. 24, 2022

Sleep quality declines with age; however, the underlying mechanisms remain elusive. We found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation during aging. In aged mice, Hcrt exhibited more frequent neuronal activity epochs driving wake bouts, and optogenetic activation of elicited prolonged wakefulness. Aged showed hyperexcitability lower KCNQ2 expression impaired M-current, mediated by KCNQ2/3 channels. Single-nucleus RNA-sequencing revealed adaptive changes to neuron loss in aging brain. Disruption

Language: Английский

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Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice

Science, Journal Year: 2022, Volume and Issue: 375(6584), P. 994 - 1000

Published: March 3, 2022

The sleep cycle is characterized by alternating non-rapid eye movement (NREM) and rapid (REM) sleeps. mechanisms which this generated are incompletely understood. We found that a transient increase of dopamine (DA) in the basolateral amygdala (BLA) during NREM terminates initiates REM sleep. DA acts on receptor D2 (Drd2)-expressing neurons BLA to induce NREM-to-REM transition. This mechanism also plays role cataplectic attacks-a pathological intrusion into wakefulness-in narcoleptics. These results show critical signaling initiating provide neuronal basis for generation.

Language: Английский

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Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

eLife, Journal Year: 2021, Volume and Issue: 10

Published: March 17, 2021

Non-rapid eye movement (NREM) sleep, characterized by slow-wave electrophysiological activity, underlies several critical functions, including learning and memory. However, NREM sleep is heterogeneous, varying in duration, depth, spatially across the cortex. While these features are thought to be largely independently regulated, there also evidence that they mechanistically coupled. To investigate how cortical controlled, we examined astrocytic network, comprising a cortex-wide syncytium influences population-level neuronal activity. We quantified endogenous astrocyte activity mice over natural wake, then manipulated specific G-protein-coupled receptor (GPCR) signaling pathways vivo. find Gi- Gq-coupled GPCR separately control depth respectively, causes differential changes local remote These data support model which network serves as hub for regulating distinct features.

Language: Английский

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A specific circuit in the midbrain detects stress and induces restorative sleep

Science, Journal Year: 2022, Volume and Issue: 377(6601), P. 63 - 72

Published: June 30, 2022

In mice, social defeat stress (SDS), an ethological model for psychosocial stress, induces sleep. Such sleep could enable resilience, but how promotes is unclear. Activity-dependent tagging revealed a subset of ventral tegmental area γ-aminobutyric acid (GABA)-somatostatin (VTA

Language: Английский

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