Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders

Molecular Psychiatry, Journal Year: 2016, Volume and Issue: 21(4), P. 450 - 463

Published: Feb. 16, 2016

The bed nucleus of the stria terminalis (BNST) is a center integration for limbic information and valence monitoring. BNST, sometimes referred to as extended amygdala, located in basal forebrain sexually dimorphic structure made up between 12 18 sub-nuclei. These sub-nuclei are rich with distinct neuronal subpopulations receptors, neurotransmitters, transporters proteins. BNST important range behaviors such as: stress response, duration fear states social behavior, all crucial determinants dysfunction human psychiatric diseases. Most research on diseases has focused which regulates immediate responses fear. However, not psychogenic circuit from hippocampus paraventricular nucleus. This stimulation hypothalamic–pituitary–adrenal axis. Thus, been largely overlooked respect its possible dysregulation mood anxiety disorders, psychological trauma, have clear gender disparities. In this review, we will look in-depth at anatomy projections provide an overview current literature relevance

Language: Английский

---

Functional Heterogeneity in the Bed Nucleus of the Stria Terminalis

Journal of Neuroscience, Journal Year: 2016, Volume and Issue: 36(31), P. 8038 - 8049

Published: Aug. 3, 2016

Early work stressed the differing involvement of central amygdala (CeA) and bed nucleus stria terminalis (BNST) in genesis fear versus anxiety, respectively. In 2009, Walker, Miles, Davis proposed a model amygdala-BNST interactions to explain these functional differences. This became extremely influential now guides new wave studies on role BNST humans. Here, we consider evidence for against this model, process highlighting principles organization. analysis leads us conclude that BNST9s influence is not limited generation anxiety-like responses diffuse threats, but it also shapes impact discrete threatening stimuli. It likely BNST-CeA are involved modulating such threats. addition, whereas current views emphasize contributions anterolateral region accumulating data indicate anteromedial anteroventral regions play critical role. The presence multiple subregions within small volume raises significant technical obstacles imaging

Language: Английский

---

Oxytocin Receptors in the Anteromedial Bed Nucleus of the Stria Terminalis Promote Stress-Induced Social Avoidance in Female California Mice

Biological Psychiatry, Journal Year: 2017, Volume and Issue: 83(3), P. 203 - 213

Published: Sept. 14, 2017

Language: Английский

---

Role of the bed nucleus of the stria terminalis in aversive learning and memory

Learning & Memory, Journal Year: 2017, Volume and Issue: 24(9), P. 480 - 491

Published: Aug. 16, 2017

Surviving threats in the environment requires brain circuits for detecting (or anticipating) danger and coordinating appropriate defensive responses (e.g., increased cardiac output, stress hormone release, freezing behavior). The bed nucleus of stria terminalis (BNST) is a critical interface between "affective forebrain"-including amygdala, ventral hippocampus, medial prefrontal cortex-and hypothalamic brainstem areas that have been implicated neuroendocrine, autonomic, behavioral to actual or anticipated threats. However, precise contribution BNST behavior unclear, both terms antecedent stimuli mobilize activity consequent reactions. For example, it well known essential contextual fear conditioning, but dispensable conditioning discrete conditioned (CSs), at least as indexed by behavior. recent evidence suggests there are circumstances which may persist independent BNST. Furthermore, involved reinstatement relapse) extinguished CSs. As such, gaps understanding how contributes fundamental processes Pavlovian conditioning. Here, we attempt provide an integrative account function We discuss distinctions unconditioned role organizing behaviors associated with these states. propose mediates responses-not based on modality duration threat response threat-but rather consequence ability stimulus predict when aversive outcome will occur (i.e., its temporal predictability). argue not uniquely mobilized sustained responses. In contrast, poorly

Language: Английский

---

Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals

eLife, Journal Year: 2019, Volume and Issue: 8

Published: April 4, 2019

The bed nucleus of the stria terminalis (BNST) has been implicated in conditioned fear and anxiety, but specific factors that engage BNST defensive behaviors are unclear. Here we examined whether mediates freezing to stimuli (CSs) poorly predict onset aversive unconditioned (USs) rats. Reversible inactivation selectively reduced CSs signaled US (e.g., a backward CS followed US), did not eliminate forward even when they predicted USs variable intensity. Additionally, (but forward) increased Fos ventral BNST-projecting neurons infralimbic region medial prefrontal cortex (mPFC), hippocampus or amygdala. These data reveal circuits regulate unpredictable threats, which may be critical etiology expression anxiety.

Language: Английский

---

The intersection of stress and reward: BNST modulation of aversive and appetitive states

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2018, Volume and Issue: 87, P. 108 - 125

Published: Jan. 9, 2018

Language: Английский

---

Complementary Neural Circuits for Divergent Effects of Oxytocin: Social Approach Versus Social Anxiety

Biological Psychiatry, Journal Year: 2018, Volume and Issue: 85(10), P. 792 - 801

Published: Oct. 25, 2018

Language: Английский

---

Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior

Molecular Psychiatry, Journal Year: 2016, Volume and Issue: 23(1), P. 143 - 153

Published: Dec. 13, 2016

Language: Английский

---

Sex differences in fear responses: Neural circuits

Neuropharmacology, Journal Year: 2022, Volume and Issue: 222, P. 109298 - 109298

Published: Oct. 31, 2022

Language: Английский

---

The bed nucleus of the stria terminalis in drug-associated behavior and affect: A circuit-based perspective

Neuropharmacology, Journal Year: 2017, Volume and Issue: 122, P. 100 - 106

Published: March 27, 2017

Language: Английский

---