The pathogenesis of depression: roles of connexin 43-based gap junctions and inflammation

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 989, P. 177260 - 177260

Published: Jan. 9, 2025

Language: Английский

---

Stress-Associated Neurobiological Pathway Linking Socioeconomic Disparities to Cardiovascular Disease

Journal of the American College of Cardiology, Journal Year: 2019, Volume and Issue: 73(25), P. 3243 - 3255

Published: June 24, 2019

Language: Английский

---

Stress and the psyche–brain–immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review

Annals of the New York Academy of Sciences, Journal Year: 2018, Volume and Issue: 1437(1), P. 31 - 42

Published: May 15, 2018

Abstract In the last decades, psychoneuroendocrineimmunology research has made relevant contributions to fields of neuroscience, psychobiology, epigenetics, molecular biology, and clinical by studying effect stress on human health highlighting close interrelations between psyche, brain, bodily systems. It is now well recognized that chronic can alter physiological cross‐talk brain biological systems, leading long‐lasting maladaptive effects (allostatic overload) nervous, immune, endocrine, metabolic which compromises resiliency health. Stressful conditions in early life have been associated with profound alterations cortical subcortical regions involved emotion regulation salience network, showing overlap different psychiatric conditions. This paper provides a summary available literature concerning notable immune system. We highlight role epigenetics as mechanistic pathway mediating influences social physical environment structure connectivity, system, psycho‐physical diseases. also summarize evidence regarding management techniques (mainly psychotherapy meditation practice) outcomes, neurocircuitry, immune‐inflammatory network major

Language: Английский

---

Interoception and Inflammation in Psychiatric Disorders

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2018, Volume and Issue: 3(6), P. 514 - 524

Published: Jan. 9, 2018

Language: Английский

---

Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation

Journal of Affective Disorders, Journal Year: 2019, Volume and Issue: 260, P. 302 - 313

Published: Sept. 3, 2019

Language: Английский

---

Control of Leukocyte Trafficking by Stress-Associated Hormones

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 9

Published: Jan. 10, 2019

Leukocyte migration is a crucial process in both homeostatic and inflammatory conditions. The spatiotemporal distribution of immune cells balanced between processes cellular mobilization into the bloodstream, their adhesion to vascular beds trafficking tissues. Systemic regulation leukocyte mobility achieved by different signals including neuronal hormonal cues, which catecholamines glucocorticoids have been most extensively studied. These hormones are often associated with stress response, however they regulate cell also steady state, effects dependent upon type, location, time-of-day, concentration, duration signal. administration catecholamines, such as sympathetic neurotransmitters adrenaline noradrenaline, increases neutrophil numbers bloodstream but has on other populations. In contrast, local, endogenous tone shown be for dynamic daily changes molecule expression bone marrow skeletal muscle, acting key signal endothelium stromal trafficking. Conversely, reported anti-inflammatory, although recent data shows more complex role, particularly under steady-state Endogenous circulating glucocorticoid concentration induce redistribution potentiate responses, many paradigms action strongly influenced time day. this review, we discuss current knowledge catecholamine stimulated

Language: Английский

---

Corticosterone Production during Repeated Social Defeat Causes Monocyte Mobilization from the Bone Marrow, Glucocorticoid Resistance, and Neurovascular Adhesion Molecule Expression

Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 38(9), P. 2328 - 2340

Published: Jan. 30, 2018

Repeated social defeat (RSD) stress promotes the release of bone marrow-derived monocytes into circulation that are recruited to brain, where they augment neuroinflammation and cause prolonged anxiety-like behavior. Physiological activates sympathetic nervous system hypothalamic-pituitary-adrenal gland (HPA) axis, both these systems play a role in physiological, immunological, behavioral responses stress. The purpose this study was delineate HPA activation corticosterone production immunological male C57BL/6 mice. Here, surgical (adrenalectomy) pharmacological (metyrapone) interventions were used abrogate signaling during We report adrenalectomy metyrapone attenuated stress-induced circulation. Neither intervention altered stress, but enhanced retention cells marrow. Consistent with observation, also prevented reduction key factor, CXCL12, Corticosterone depletion abrogated glucocorticoid resistance myeloid cells. In corticosterone-associated microglial remodeling, neurovascular expression adhesion molecule intercellular cell molecule-1, monocyte accumulation neuroinflammatory signaling. Overall, results indicate repeated critical for circulation, cells, expression. SIGNIFICANCE STATEMENT Recent studies have identified presence show an exaggerated inflammatory response immune challenge resistant suppressive effects glucocorticoids. Increased proinflammatory has been implicated neuropsychiatric symptoms development chronic cardiovascular, autoimmune, metabolic disorders. current study, we novel evidence produced enhances from marrow augments their recruitment brain induction profile. Overproduction is direct resistance, phenotype individuals exposed Inhibiting excess attenuates

Language: Английский

---

Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress

Physiology & Behavior, Journal Year: 2017, Volume and Issue: 171, P. 69 - 78

Published: Jan. 7, 2017

Language: Английский

---

Microglia: Neuroimmune-sensors of stress

Seminars in Cell and Developmental Biology, Journal Year: 2019, Volume and Issue: 94, P. 176 - 185

Published: Jan. 9, 2019

Language: Английский

---

Neuroendocrine Regulation of Brain Cytokines After Psychological Stress

Journal of the Endocrine Society, Journal Year: 2019, Volume and Issue: 3(7), P. 1302 - 1320

Published: May 14, 2019

There is growing evidence that stress-induced brain cytokines are important in the etiology of depression and anxiety. Here, we review how neuroendocrine responses to psychological stressors affect immediate long-term regulation inflammatory within highlight changes across time with repeated stress exposure. In doing so, report on percentage studies literature observed increases either IL-1β, TNF-α, or IL-6 hypothalamus, hippocampus, prefrontal cortex after acute chronic The key takeaway catecholamines glucocorticoids play critical roles Central stimulate release IL-1β from microglia, which a factor further activation microglia recruitment monocytes into brain. Meanwhile, elevation inhibits production via two mechanisms: suppression noradrenergic locus coeruleus neurons inhibition NFκB signaling pathway. However, peripheral facilitate future stimuli by stimulating leave bone marrow, downregulating inhibitory receptors priming mediated macrophages. glucocorticoid catecholamine levels both necessary during times exposure for development psychopathologies.

Language: Английский

---