The Bidirectional Relationship of Depression and Inflammation: Double Trouble

Neuron, Journal Year: 2020, Volume and Issue: 107(2), P. 234 - 256

Published: June 17, 2020

Language: Английский

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Neuroscience of apathy and anhedonia: a transdiagnostic approach

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(8), P. 470 - 484

Published: June 26, 2018

Language: Английский

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What does plasma CRP tell us about peripheral and central inflammation in depression?

Molecular Psychiatry, Journal Year: 2018, Volume and Issue: 25(6), P. 1301 - 1311

Published: June 12, 2018

Language: Английский

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Imaging the Role of Inflammation in Mood and Anxiety-related Disorders

Current Neuropharmacology, Journal Year: 2017, Volume and Issue: 16(5), P. 533 - 558

Published: Nov. 25, 2017

Background: Studies investigating the impact of a variety inflammatory stimuli on brain and behavior have reported evidence that inflammation release cytokines affect circuitry relevant to both reward threat sensitivity contribute behavioral change. Of relevance mood anxiety-related disorders, biomarkers such as acute-phase proteins are reliably elevated in significant proportion patients with major depressive disorder (MDD), bipolar disorder, anxiety disorders post-traumatic stress (PTSD). Methods: This review summarized clinical translational work demonstrating peripheral regions neurotransmitter systems sensitivity, focus neuroimaging studies involving administration stimuli. Recent translation these findings further understand role is also discussed. Results: Inflammation was consistently found basal ganglia cortical motor circuits drive reduced motivation activity, well including amygdala, insula anterior cingulate cortex, which may result from cytokine effects monoamines glutamate. Similar relationships between altered neurocircuitry been observed MDD increased markers, horizon for PTSD. Conclusion: Neuroimaging be used future development novel therapeutic strategies better treat high inflammation. Keywords: Neuroimaging, inflammation, cytokines, microglia, depression, anxiety, PTSD, motivation, slowing.

Language: Английский

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Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 88(5), P. 369 - 380

Published: Jan. 28, 2020

Language: Английский

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Resilience and immunity

Brain Behavior and Immunity, Journal Year: 2018, Volume and Issue: 74, P. 28 - 42

Published: Aug. 10, 2018

Resilience is the process that allows individuals to adapt adverse conditions and recover from them. This favored by individual qualities have been amply studied in field of stress such as personal control, positive affect, optimism, social support. Biopsychosocial studies on promote resilience show these factors help protect against deleterious influences stressors physiology general immunity particular. The reverse also true there evidence immune processes influence resilience. Most data supporting this relationship comes animal differences ability resist situations chronic stress. These build knowledge has accumulated brain behavior both human studies. In general, resilient a different immunophenotype susceptible individuals. It possible render vice versa changing their inflammatory phenotype. adaptive phenotype inflammation-induced symptoms. modulation bidirectional relationships between gut microbiota opens possibility them probiotics prebiotics. However, more focused reciprocal will be necessary before can put into practice.

Language: Английский

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Neuropsychological and neurophysiological correlates of fatigue in post-acute patients with neurological manifestations of COVID-19: Insights into a challenging symptom

Journal of the Neurological Sciences, Journal Year: 2020, Volume and Issue: 420, P. 117271 - 117271

Published: Dec. 16, 2020

Language: Английский

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Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

Translational Psychiatry, Journal Year: 2020, Volume and Issue: 10(1)

Published: May 20, 2020

It is broadly acknowledged that the onset of dementia in Alzheimer's disease (AD) may be modifiable by management risk factors. While several recent guidelines and multidomain intervention trials on prevention cognitive decline address lifestyle factors diseases, such as hypertension diabetes, a special reference to established factor depression or depressive symptoms systematically lacking. In this article we review epidemiological studies biological mechanisms linking with AD decline. We also emphasize effects antidepressive treatment pathology including molecular antidepressants neurogenesis, amyloid burden, tau pathology, inflammation. advocate moving into focus dementia. constitute early impact course affect developing propose need for clinical trials.

Language: Английский

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Stress-induced plasticity and functioning of ventral tegmental dopamine neurons

Neuroscience & Biobehavioral Reviews, Journal Year: 2019, Volume and Issue: 108, P. 48 - 77

Published: Oct. 27, 2019

The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional, motivational, and social reward associations together with their more demanding cognitive aspects that involve the mesocortical circuitry. Coping stress increases VTA-DA excitability, but when stressor becomes chronic is less active, which may lead to degeneration local microglial activation. This switch between activation inhibition of neurons modulated by e.g. corticotropin-releasing hormone (CRH), opioids, brain-derived neurotrophic factor (BDNF), adrenal glucocorticoids. These actions are coordinated energy-demanding stress-coping styles promote behavioral adaptation. VTA circuits show sexual dimorphism programmed sex hormones during perinatal life in a manner can be affected glucocorticoid exposure. We conclude insight role plasticity connectivity, processing stress-coping, will helpful better understand mechanism resilience breakdown

Language: Английский

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Fatigue, Sleep, and Autoimmune and Related Disorders

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Aug. 6, 2019

Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac chronic syndrome, rheumatoid arthritis. Fatigue multi-faceted broadly defined, which makes understanding cause of its manifestations especially difficult in conditions diverse pathology including diseases. In general, defined by periods exhaustion that interfere normal activities. The severity duration episodes vary, but can difficulty for even simple tasks like climbing stairs or crossing room. exact mechanisms are not well understood, perhaps due to broad definition. Nevertheless, physiological processes known play a role include oxygen/nutrient supply, metabolism, mood, motivation, sleepiness—all affected inflammation. Additionally, an important contributing element central nervous system—a region impacted either directly indirectly numerous related disorders. This review describes how inflammation system contribute suggests potential involved likely exhibited

Language: Английский

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