The Influence of Adverse Childhood Experiences in Pain Management: Mechanisms, Processes, and Trauma-Informed Care DOI Creative Commons
Lydia V. Tidmarsh, Richard Harrison, Deepak Ravindran

et al.

Frontiers in Pain Research, Journal Year: 2022, Volume and Issue: 3

Published: June 10, 2022

Adverse childhood experiences (ACEs) increase the likelihood of reduced physical and psychological health in adulthood. Though understanding management traumatic is growing, empirical exploration ACEs clinical outcomes remains under-represented under-explored. This topical review aimed to highlight role experience chronic pain, pain services decision making by: ( 1 ) providing an overview relationship between pain; 2 identifying biopsychosocial mechanisms through which may risk persistent 3 highlighting impact on patient adherence completion treatment; 4 practical implications for management. Review findings demonstrated that are associated with increased complications, catastrophizing depression combination these factors further heightens early treatment attrition. The pervasive detrimental impacts COVID-19 pandemic their cyclical effects discussed context decline during long waitlists. highlights how people can be supported by maintaining trauma-informed practices acknowledging outcomes. Clinicians who ACE-informed have potential minimize negative influence outcomes, ultimately optimizing services.

Language: Английский

Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation DOI Creative Commons
Agorastos Agorastos, Panagiota Pervanidou, George P. Chrousos

et al.

Frontiers in Psychiatry, Journal Year: 2019, Volume and Issue: 10

Published: March 11, 2019

Early life stressors display a high universal prevalence and constitute major public health problem. Prolonged psychoneurobiological alterations as sequelae of early stress (ELS) could represent developmental risk factor mediate for disease, leading to higher physical mental morbidity rates in later life. ELS exert programming effect on sensitive neuronal brain networks related the response during critical periods development thus lead enduring hyper- or hypo-activation system altered glucocorticoid signaling. In addition, emotional autonomic reactivity, circadian rhythm disruption, functional structural changes brain, well immune metabolic dysregulation have been lately identified important factors chronically impaired homeostatic balance after ELS. Furthermore, human genetic background epigenetic modifications through stress-related gene expression interact with these explain inter-individual variation vulnerability resilience stress. This narrative review presents relevant evidence from mainly research ten most acknowledged neurobiological allostatic pathways exerting adverse effects even decades (hypothalamic-pituitary-adrenal axis, nervous system, inflammation, oxidative stress, cardiovascular gut microbiome, sleep genetics, epigenetics, structural, correlates). Although findings back causal relation between psychobiological maladjustment life, precise trajectories their temporal coincidence has not elucidated yet. Future studies should prospectively investigate putative mediators sequence, while considering potentially delayed time-frame phenotypical expression. Better screening strategies are needed better individual prevention treatment.

Language: Английский

Citations

314
Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression DOI
Yuri Milaneschi, Femke Lamers, Michael Berk

et al.

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 88(5), P. 369 - 380

Published: Jan. 28, 2020

Language: Английский

Citations

311
Early life stress and development: potential mechanisms for adverse outcomes DOI Creative Commons
Karen E. Smith, Seth D. Pollak

Journal of Neurodevelopmental Disorders, Journal Year: 2020, Volume and Issue: 12(1)

Published: Dec. 1, 2020

Abstract Background Chronic and/or extreme stress in early life, often referred to as adversity, childhood trauma, or life stress, has been associated with a wide range of adverse effects on development. However, while linked negative number neural systems, the specific mechanisms through which influences development and individual differences children’s outcomes are still not well understood. Main text The current paper reviews existing literature neurobiological their ties psychological behavioral Conclusions Early persistent pervasive prefrontal–hypothalamic–amygdala dopaminergic circuits that at least partially mediated by alterations hypothalamic–pituitary–adrenal axis function. date, this research primarily utilized methods assessment focus solely event exposures. Incorporating factors influence interpretation stressors, along stressful events, potential provide further insight into contributing neurodevelopmental stress. This can aid elucidating these changes contribute risk for psychopathology health disorders.

Language: Английский

Citations

302
Rethinking Concepts and Categories for Understanding the Neurodevelopmental Effects of Childhood Adversity DOI Creative Commons
Karen E. Smith, Seth D. Pollak

Perspectives on Psychological Science, Journal Year: 2020, Volume and Issue: 16(1), P. 67 - 93

Published: July 15, 2020

Discovering the processes through which early adverse experiences affect children’s nervous-system development, health, and behavior is critically important for developing effective interventions. However, advances in our understanding of these have been constrained by conceptualizations that rely on categories adversity are overlapping, vague boundaries, lack consistent biological evidence. Here, we discuss central problems link between early-life brain development. We conclude suggesting alternative formulations hold promise advancing knowledge about neurobiological mechanisms affects human

Language: Английский

Citations

290
Non-Genetic Factors in Schizophrenia DOI Creative Commons

Simona A. Stilo,

Robin M. Murray

Current Psychiatry Reports, Journal Year: 2019, Volume and Issue: 21(10)

Published: Sept. 14, 2019

Abstract Purpose of Review We review recent developments on risk factors in schizophrenia. Recent Findings The way we think about schizophrenia today is profoundly different from the this illness was seen twentieth century. now know that etiology multifactorial and reflects an interaction between genetic vulnerability environmental contributors. Environmental such as pregnancy birth complications, childhood trauma, migration, social isolation, urbanicity, substance abuse, alone combination, acting at a number levels over time, influence individual’s likelihood to develop disorder. Summary together with identification polygenic score for schizophrenia, research gene–environment environment–environment have hugely increased our knowledge

Language: Английский

Citations

253
Neurobiology of Resilience: Interface Between Mind and Body DOI
Flurin Cathomas, James W. Murrough, Eric J. Nestler

et al.

Biological Psychiatry, Journal Year: 2019, Volume and Issue: 86(6), P. 410 - 420

Published: April 17, 2019

Language: Английский

Citations

248
Inflammation: A Proposed Intermediary Between Maternal Stress and Offspring Neuropsychiatric Risk DOI
Liisa Hantsoo, Sara L. Kornfield, Montserrat C. Anguera

et al.

Biological Psychiatry, Journal Year: 2018, Volume and Issue: 85(2), P. 97 - 106

Published: Sept. 5, 2018

Language: Английский

Citations

225
Is the HPA Axis as Target for Depression Outdated, or Is There a New Hope? DOI Creative Commons
Andreas Menke

Frontiers in Psychiatry, Journal Year: 2019, Volume and Issue: 10

Published: Feb. 28, 2019

Major depressive disorder (MDD) is a very common stress-related mental that carries huge burden for affected patients and the society. It associated with high mortality derives from suicidality development of serious medical conditions such as heart diseases, diabetes stroke. Although range effective antidepressants are available, more than 50% do not respond to first treatment they prescribed around 30% fail even after several attempts. The heterogeneous condition MDD, lack biomarkers matching right treatments situation almost all available drugs only targeting serotonin, norepinephrine or dopamine signaling, without regulating other potentially dysregulated systems may explain insufficient status. hypothalamic-pituitary-adrenal (HPA) axis one these systems, there numerous robust evidence it implicated in MDD conditions, but up date no specific drug HPA components approved test routinely used clinical setting identifying treatment. Is still hope many years breakthrough agents axis? This review will cover tests detecting altered function options glucocorticoid receptor (GR) antagonists, corticotropin-releasing hormone 1 (CRH1) tryptophan 2,3-dioxygenase (TDO) inhibitors FK506 binding protein 5 (FKBP5) antagonists.

Language: Английский

Citations

218
Intergenerational Transmission of Maternal Childhood Maltreatment Exposure: Implications for Fetal Brain Development DOI Open Access
Claudia Buß, Sonja Entringer, Nora K. Moog

et al.

Journal of the American Academy of Child & Adolescent Psychiatry, Journal Year: 2017, Volume and Issue: 56(5), P. 373 - 382

Published: March 10, 2017

Language: Английский

Citations

212
The adverse childhood experiences questionnaire: Two decades of research on childhood trauma as a primary cause of adult mental illness, addiction, and medical diseases DOI Creative Commons

Emily M. Zarse,

Mallory R. Neff,

Rachel Yoder

et al.

Cogent Medicine, Journal Year: 2019, Volume and Issue: 6(1), P. 1581447 - 1581447

Published: Jan. 1, 2019

Objective. In 1998, Felitti and colleagues published the first study of Adverse Childhood Experiences-Questionnaire (ACE-Q), a 10-item scale used to correlate childhood maltreatment adverse rearing contexts with adult health outcomes. This paper qualitatively reviews nearly two decades research utilizing ACE-Q, highlighting its contribution our understanding causal roots common, interlinked comorbidities brain body.Methods. An OVID/PubMed search was conducted for English language articles before 2016, containing phrase "Adverse Experiences" in which ACE-Q utilized. Source review included manual bibliographies, resulting 134 articles, including 44 based on original population.Results. has demonstrated that exposures experiences converge dose-dependently potently increase risk wide array causally mental illnesses, addictions, multi-organ medical diseases. The intergenerational transmission this disease burden via disrupted parenting insecure is apparent throughout literature. However, does not tease out genetic or fetal drug exposure components transmission.Conclusions. may generate public could rival exceed all other root causes. Translating information health-care reform will require strengthening brain-behavioral as core preventative missions. Greater integration addiction services parents should be accompanied by more into mechanisms impacted different forms interactions between experiences.

Language: Английский

Citations

187