Identification of neutral tumor evolution across cancer types DOI
Marc Williams, Benjamin Werner, C. Barnes

et al.

Nature Genetics, Journal Year: 2016, Volume and Issue: 48(3), P. 238 - 244

Published: Jan. 18, 2016

Language: Английский

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity DOI
Kristen M. Turner, Viraj Deshpande, Doruk Beyter

et al.

Nature, Journal Year: 2017, Volume and Issue: 543(7643), P. 122 - 125

Published: Feb. 8, 2017

Language: Английский

Citations

669
A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer DOI Creative Commons
Johanna Wagner, Maria Anna Rapsomaniki, Stéphane Chevrier

et al.

Cell, Journal Year: 2019, Volume and Issue: 177(5), P. 1330 - 1345.e18

Published: April 11, 2019

Language: Английский

Citations

669
Three-dimensional organotypic culture: experimental models of mammalian biology and disease DOI
Eliah R. Shamir, Andrew J. Ewald

Nature Reviews Molecular Cell Biology, Journal Year: 2014, Volume and Issue: 15(10), P. 647 - 664

Published: Sept. 17, 2014

Language: Английский

Citations

663
New horizons in tumor microenvironment biology: challenges and opportunities DOI Creative Commons
Fei Chen,

Xueqian Zhuang,

Liangyu Lin

et al.

BMC Medicine, Journal Year: 2015, Volume and Issue: 13(1)

Published: March 4, 2015

The tumor microenvironment (TME) is being increasingly recognized as a key factor in multiple stages of disease progression, particularly local resistance, immune-escaping, and distant metastasis, thereby substantially impacting the future development frontline interventions clinical oncology. An appropriate understanding TME promotes evaluation selection candidate agents to control malignancies at both primary sites well metastatic settings. This review presents timely outline research advances biology highlights prospect targeting critical strategy overcome acquired prevent improve therapeutic efficacy. As benign cells niches actively modulate response cancer broad range standard chemotherapies targeted agents, cancer-oriented therapeutics should be combined with TME-targeting treatments achieve optimal outcomes. Overall, body updated information delivered summarize recently emerging rapidly progressing aspects studies, provide significant guideline for prospective personalized medicine, long term aim providing cure patients.

Language: Английский

Citations

648
Identification of neutral tumor evolution across cancer types DOI
Marc Williams, Benjamin Werner, C. Barnes

et al.

Nature Genetics, Journal Year: 2016, Volume and Issue: 48(3), P. 238 - 244

Published: Jan. 18, 2016

Language: Английский

Citations

605