Pharmacological Research,
Journal Year:
2022,
Volume and Issue:
187, P. 106610 - 106610
Published: Dec. 12, 2022
Gastric
cancer
(GC)
occurs
in
the
gastric
mucosa,
and
its
high
morbidity
mortality
make
it
an
international
health
crisis.
Therefore,
novel
drugs
are
needed
for
treatment.
The
use
of
natural
products
their
components
treatments
has
shown
promise.
this
study
aimed
to
evaluate
effect
8-paradol,
a
phenolic
compound
isolated
from
ginger
(Zingiber
officinale
Roscoe),
on
GC
determine
underlying
mechanisms
action.
In
study,
repeated
column
chromatography
was
conducted
EtOH
extract
isolate
gingerol
derivatives.
cytotoxicity
eight
compounds
underwent
(3-(4,5-dimethylthiazol-2-yl)−
2,5-diphenyltetrazolium
bromide)
tetrazolium
reduction
(MTT)
assay.
8-paradol
showed
most
potent
among
compounds.
mechanism
by
which
regulated
specific
proteins
AGS
cells
evaluated
proteomic
analysis.
To
validate
predicted
mechanisms,
thymus-deficient
nude
mice
bearing
xenografts
were
used
as
vitro
vivo
models
GC,
respectively.
results
that
promoted
PINK1/Parkin-associated
mitophagy,
mediating
cell
apoptosis.
Additionally,
inhibition
mitophagy
chloroquine
(CQ)
ameliorated
8-paradol-induced
mitochondrial
dysfunction
apoptosis,
supporting
causative
role
anticancer
effect.
Molecular
docking
revealed
molecular
interactions
between
mitophagy-/
apoptosis-related
at
atomic
level.
Our
provides
strong
evidence
could
act
potential
therapeutic
agent
suppress
progression
targeting
pathway.
Cancer Research,
Journal Year:
2013,
Volume and Issue:
73(24), P. 7176 - 7188
Published: Oct. 24, 2013
Circadian
timing
of
anticancer
medications
has
improved
treatment
tolerability
and
efficacy
several
fold,
yet
with
intersubject
variability.
Using
three
C57BL/6-based
mouse
strains
both
sexes,
we
identified
chronotoxicity
classes
distinct
circadian
toxicity
patterns
irinotecan,
a
topoisomerase
I
inhibitor
active
against
colorectal
cancer.
Liver
colon
24-hour
expression
clock
genes
Rev-erbα
Bmal1
best
discriminated
these
classes,
among
27
transcriptional
time
series,
according
to
sparse
linear
discriminant
analysis.
An
8-hour
phase
advance
was
found
for
mRNA
expressions
irinotecan
in
clock-altered
Per2(m/m)
mice.
The
application
maximum-a-posteriori
Bayesian
inference
method
model
based
on
that
accurately
predicted
optimal
timing.
assessment
the
regulatory
transcription
loop
molecular
could
critically
improve
chemotherapy
through
mathematical
model-based
determination
host-specific
Current Opinion in Clinical Nutrition & Metabolic Care,
Journal Year:
2013,
Volume and Issue:
16(5), P. 525 - 533
Published: June 25, 2013
Reducing
cancer-treatment
toxicity
was
a
largely
ignored
research
agenda,
which
is
now
emerging
as
an
active
area
of
investigation.
Studies
human
body
composition
using
computerized
tomography
scans
have
provided
proof-of-concept
that
variability
in
drug
disposition
and
profiles
may
be
partially
explained
by
different
features
composition.Collectively,
studies
suggest
skeletal
muscle
depletion
(regardless
weight)
independent
predictor
severe
toxicity,
affecting
cancer
treatment
its
outcomes.
Although
precise
mechanisms
are
unknown,
pharmacokinetic
parameters
such
variations
volume
distribution
increased
exposure
explain
findings.Computerized
readily
available
clinical
databases
diagnostic
images
provide
feasible,
reliable,
highly
differentiated
measurements
composition.
These
should
used
to
optimize
screening
management
patients
order
prevent
improve
the
efficacy
cost-efficiency
chemotherapy
treatments.
Pharmacological Research,
Journal Year:
2022,
Volume and Issue:
187, P. 106610 - 106610
Published: Dec. 12, 2022
Gastric
cancer
(GC)
occurs
in
the
gastric
mucosa,
and
its
high
morbidity
mortality
make
it
an
international
health
crisis.
Therefore,
novel
drugs
are
needed
for
treatment.
The
use
of
natural
products
their
components
treatments
has
shown
promise.
this
study
aimed
to
evaluate
effect
8-paradol,
a
phenolic
compound
isolated
from
ginger
(Zingiber
officinale
Roscoe),
on
GC
determine
underlying
mechanisms
action.
In
study,
repeated
column
chromatography
was
conducted
EtOH
extract
isolate
gingerol
derivatives.
cytotoxicity
eight
compounds
underwent
(3-(4,5-dimethylthiazol-2-yl)−
2,5-diphenyltetrazolium
bromide)
tetrazolium
reduction
(MTT)
assay.
8-paradol
showed
most
potent
among
compounds.
mechanism
by
which
regulated
specific
proteins
AGS
cells
evaluated
proteomic
analysis.
To
validate
predicted
mechanisms,
thymus-deficient
nude
mice
bearing
xenografts
were
used
as
vitro
vivo
models
GC,
respectively.
results
that
promoted
PINK1/Parkin-associated
mitophagy,
mediating
cell
apoptosis.
Additionally,
inhibition
mitophagy
chloroquine
(CQ)
ameliorated
8-paradol-induced
mitochondrial
dysfunction
apoptosis,
supporting
causative
role
anticancer
effect.
Molecular
docking
revealed
molecular
interactions
between
mitophagy-/
apoptosis-related
at
atomic
level.
Our
provides
strong
evidence
could
act
potential
therapeutic
agent
suppress
progression
targeting
pathway.
