Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Nov. 8, 2022
Abstract
As
an
evolutionarily
conserved
signalling
network,
the
Hippo
pathway
plays
a
crucial
role
in
regulation
of
numerous
biological
processes.
Thus,
substantial
efforts
have
been
made
to
understand
upstream
signals
that
influence
activity
pathway,
as
well
its
physiological
functions,
such
cell
proliferation
and
differentiation,
organ
growth,
embryogenesis,
tissue
regeneration/wound
healing.
However,
dysregulation
can
cause
variety
diseases,
including
cancer,
eye
cardiac
pulmonary
renal
hepatic
immune
dysfunction.
Therefore,
therapeutic
strategies
target
dysregulated
components
might
be
promising
approaches
for
treatment
wide
spectrum
diseases.
Here,
we
review
key
critical
functions
controlled
by
pathway.
Additionally,
diseases
associated
with
alterations
potential
therapies
targeting
will
discussed.
New England Journal of Medicine,
Journal Year:
2015,
Volume and Issue:
374(2), P. 135 - 145
Published: Nov. 4, 2015
Papillary
renal-cell
carcinoma,
which
accounts
for
15
to
20%
of
carcinomas,
is
a
heterogeneous
disease
that
consists
various
types
renal
cancer,
including
tumors
with
indolent,
multifocal
presentation
and
solitary
an
aggressive,
highly
lethal
phenotype.
Little
known
about
the
genetic
basis
sporadic
papillary
no
effective
forms
therapy
advanced
exist.We
performed
comprehensive
molecular
characterization
161
primary
using
whole-exome
sequencing,
copy-number
analysis,
messenger
RNA
microRNA
DNA-methylation
proteomic
analysis.Type
1
type
2
carcinomas
were
shown
be
different
cancer
characterized
by
specific
alterations,
further
classified
into
three
individual
subgroups
on
differences
associated
patient
survival.
Type
MET
whereas
CDKN2A
silencing,
SETD2
mutations,
TFE3
fusions,
increased
expression
NRF2-antioxidant
response
element
(ARE)
pathway.
A
CpG
island
methylator
phenotype
(CIMP)
was
observed
in
distinct
subgroup
poor
survival
mutation
gene
encoding
fumarate
hydratase
(FH).Type
clinically
biologically
distinct.
Alterations
pathway
1,
activation
NRF2-ARE
2;
loss
CIMP
conveyed
prognosis.
Furthermore,
carcinoma
consisted
at
least
subtypes
based
phenotypic
features.
(Funded
National
Institutes
Health.).
Endocrine Reviews,
Journal Year:
2014,
Volume and Issue:
36(1), P. 1 - 24
Published: Oct. 10, 2014
Although
hormonal
regulation
of
ovarian
follicle
development
has
been
extensively
investigated,
most
studies
concentrate
on
the
early
antral
follicles
to
preovulatory
stage,
leading
successful
use
exogenous
FSH
for
infertility
treatment.
Accumulating
data
indicate
that
preantral
are
under
stringent
by
and
local
intraovarian
factors,
thus
providing
possibility
develop
new
therapeutic
approaches.
Granulosa
cell-derived
C-type
natriuretic
factor
not
only
suppresses
final
maturation
oocytes
undergo
germinal
vesicle
breakdown
before
ovulation
but
also
promotes
growth.
In
addition,
several
oocyte-
granulosa
factors
stimulate
growth
acting
through
wingless,
receptor
tyrosine
kinase,
serine
other
signaling
pathways.
contrast,
Hippo
pathway
constrains
disruption
secretion
downstream
CCN
capable
promoting
exact
involved
in
primordial
activation
yet
be
elucidated,
protein
kinase
B
(AKT)
mammalian
target
rapamycin
pathways
important
dormant
follicles.
after
fragmentation,
combined
with
treating
fragments
phosphatase
tensin
homolog
(PTEN)
inhibitors
phosphoinositide-3-kinase
stimulators
augment
AKT
signaling,
promote
patients
primary
insufficiency,
a
intervention
such
patients.
Elucidation
mechanisms
underlying
folliculogenesis
may
allow
novel
strategies
diagnosed
polycystic
ovary
syndrome,
poor
response
stimulation,
as
well
infertile
women
advanced
reproductive
age.
