Osteoporosis treatment: recent developments and ongoing challenges

The Lancet Diabetes & Endocrinology, Journal Year: 2017, Volume and Issue: 5(11), P. 898 - 907

Published: July 7, 2017

Language: Английский

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The great escape: tumour cell plasticity in resistance to targeted therapy

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: 19(1), P. 39 - 56

Published: Oct. 10, 2019

Language: Английский

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T memory stem cells in health and disease

Nature Medicine, Journal Year: 2017, Volume and Issue: 23(1), P. 18 - 27

Published: Jan. 1, 2017

Language: Английский

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The Wnt signaling pathway in cancer

Critical Reviews in Oncology/Hematology, Journal Year: 2015, Volume and Issue: 99, P. 141 - 149

Published: Dec. 24, 2015

Language: Английский

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Regulated cell death pathways in doxorubicin-induced cardiotoxicity

Cell Death and Disease, Journal Year: 2021, Volume and Issue: 12(4)

Published: April 1, 2021

Abstract Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited use potent drug. The mechanisms by which doxorubicin kills cardiomyocytes been elusive despite extensive research exact remain unknown. This review focuses on recent advances in our understanding induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis apoptosis. Understanding leads to may help identify novel therapeutic agents lead more targeted approaches cardiotoxicity testing.

Language: Английский

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Wnt–β-catenin signalling in liver development, health and disease

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2018, Volume and Issue: 16(2), P. 121 - 136

Published: Nov. 19, 2018

Language: Английский

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Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: June 10, 2021

Abstract To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME), and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence progression because of versatile roles extracellular matrix remodeling, maintenance stemness, blood vessel formation, modulation metabolism, immune response, promotion cell proliferation, migration, invasion, therapeutic resistance. CAFs highly heterogeneous stromal cells crosstalk with is mediated by a complex intricate signaling network consisting transforming growth factor-beta, phosphoinositide 3-kinase/AKT/mammalian target rapamycin, mitogen-activated protein kinase, Wnt, Janus kinase/signal transducers activators transcription, epidermal factor receptor, Hippo, nuclear kappa-light-chain-enhancer activated B cells, etc., pathways. These signals exhibit own special characteristics during the have potential to be targeted anticancer therapy. Therefore, comprehensive understanding these cascades interactions between necessary fully realize pivotal cancers. Herein, this review, we will summarize enormous amounts findings mediating its related targets or trials. Further, hypothesize three targeting strategies, including, namely, epithelial–mesenchymal common targets, sequential perturbation, crosstalk-directed paving way CAF-directed host cell-directed antitumor

Language: Английский

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Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

Molecular Cancer, Journal Year: 2020, Volume and Issue: 19(1)

Published: Nov. 24, 2020

Abstract Wnt signaling is a highly conserved pathway that plays critical role in controlling embryonic and organ development, as well cancer progression. Genome-wide sequencing gene expression profile analyses have demonstrated involved mainly the processes of breast proliferation metastasis. The most recent studies indicated also crucial immune microenvironment regulation, stemness maintenance, therapeutic resistance, phenotype shaping, etc. Wnt/β-Catenin, Wnt–planar cell polarity (PCP), Wnt–Ca 2+ are three well-established pathways share overlapping components play different roles In this review, we summarize main findings concerning relationship between provide an overview existing mechanisms, challenges, potential opportunities for advancing therapy diagnosis cancer.

Language: Английский

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Immune Checkpoint Inhibitors: Basics and Challenges

Current Medicinal Chemistry, Journal Year: 2017, Volume and Issue: 26(17), P. 3009 - 3025

Published: Aug. 7, 2017

Cancer is one of the most deadly diseases in modern world. The last decade has witnessed dramatic advances cancer treatment through immunotherapy. One extremely promising means to achieve anti-cancer immunity block immune checkpoint pathways - mechanisms adopted by cells disguise themselves as regular components human body. Many review articles have described a variety agents that are currently under extensive clinical evaluation. However, while blockade universally effective against broad spectrum types and mostly unrestricted mutation status certain genes, only minority patients complete response. In this review, we summarize basic principles inhibitors both antibody smallmolecule forms also discuss potential resistance, which may shed light on further investigation higher efficacy for these inhibitors.

Language: Английский

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Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge

Frontiers in Medicine, Journal Year: 2015, Volume and Issue: 2

Published: Sept. 3, 2015

Chronic organ injury leads to fibrosis and eventually failure. Fibrosis is characterized by excessive synthesis, remodeling contraction of extracellular matrix produced myofibroblasts. Myofibroblasts are the key cells in pathophysiology fibrotic disorders their differentiation can be triggered multiple stimuli. To develop anti-fibrotic therapies, it paramount importance understand molecular basis signaling pathways contributing activation maintenance Several signal transduction such as TGF-β, Wnt, more recently YAP/TAZ signaling, have been linked fibrosis. Activation TGF-β1-induced SMAD complex results upregulation genes important for myofibroblast function. Similarly, Wnt-stabilized β-catenin translocates nucleus initiates transcription its target genes. YAP TAZ two transcriptional co-activators from Hippo pathway that also rely on nuclear translocation functioning. These three little similarity but do share one principle: cytosolic/nuclear regulation activators. Past research these often focused isolated cascades without taking other into account. Recent developments show parts converge an intricate network governs phenotype. In this review we discuss current understanding integration between development Taking a wide view will provide better versatile processes underlie disorders.

Language: Английский

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