RNA sequencing: the teenage years

Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 20(11), P. 631 - 656

Published: July 24, 2019

Language: Английский

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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Aug. 18, 2023

Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, growth, and cycle progression. Growth factor signalling to transcription factors the PAM axis regulated by multiple cross-interactions with several other pathways, dysregulation of can predispose cancer development. most frequently activated human often implicated resistance anticancer therapies. Dysfunction components this such as hyperactivity PI3K, loss function PTEN, gain-of-function AKT, are notorious drivers treatment disease progression cancer. In review we highlight major dysregulations cancer, discuss results AKT mTOR inhibitors monotherapy co-administation antineoplastic agents clinical trials strategy for overcoming resistance. Finally, mechanisms targeted therapies, including immunology immunotherapies also discussed.

Language: Английский

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RNA-Binding Proteins in Cancer: Old Players and New Actors

Trends in cancer, Journal Year: 2017, Volume and Issue: 3(7), P. 506 - 528

Published: June 21, 2017

Language: Английский

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Ribosome biogenesis in cancer: new players and therapeutic avenues

Nature reviews. Cancer, Journal Year: 2017, Volume and Issue: 18(1), P. 51 - 63

Published: Dec. 1, 2017

Language: Английский

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mRNA-based therapeutics: powerful and versatile tools to combat diseases

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: May 21, 2022

Abstract The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range incurable diseases. Recent rapid advances in biotechnology and molecular medicine have enabled the production almost any functional protein/peptide human body by introducing mRNA as vaccine or agent. This represents rising precision field with promise for preventing treating many intractable genetic In addition, vitro transcribed achieved programmed production, which is more effective, faster design well flexible cost-effective than conventional approaches that may offer. Based on these extraordinary advantages, vaccines characteristics swiftest response large-scale outbreaks infectious diseases, such currently devastating pandemic COVID-19. It always been scientists’ desire improve stability, immunogenicity, translation efficiency, delivery system achieve efficient safe mRNA. Excitingly, scientific dreams gradually realized rapid, amazing achievements biology, technology, vaccinology, nanotechnology. this review, we comprehensively describe mRNA-based therapeutics, including their principles, manufacture, application, effects, shortcomings. We also highlight importance optimization systems successful therapeutics discuss key challenges opportunities developing tools into powerful versatile genetic, infectious, cancer, other refractory

Language: Английский

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The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity

Cell, Journal Year: 2017, Volume and Issue: 169(6), P. 1051 - 1065.e18

Published: June 1, 2017

Language: Английский

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Non-AUG translation: a new start for protein synthesis in eukaryotes

Genes & Development, Journal Year: 2017, Volume and Issue: 31(17), P. 1717 - 1731

Published: Sept. 1, 2017

Although it was long thought that eukaryotic translation almost always initiates at an AUG start codon, recent advancements in ribosome footprint mapping have revealed non-AUG codons are used astonishing frequency. These initiation events not simply errors but instead to generate or regulate proteins with key cellular functions; for example, during development stress. Misregulation of contributes multiple human diseases, including cancer and neurodegeneration, modulation usage may represent a novel therapeutic strategy. It is thus becoming increasingly clear codon selection regulated by many trans-acting factors as well sequence/structural elements within messenger RNAs has profound impact on states.

Language: Английский

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mTOR as a central regulator of lifespan and aging

F1000Research, Journal Year: 2019, Volume and Issue: 8, P. 998 - 998

Published: July 2, 2019

The mammalian/mechanistic target of rapamycin (mTOR) is a key component cellular metabolism that integrates nutrient sensing with processes fuel cell growth and proliferation. Although the involvement mTOR pathway in regulating life span aging has been studied extensively last decade, underpinning mechanisms remain elusive. In this review, we highlight emerging insights link to various related aging, such as sensing, maintenance proteostasis, autophagy, mitochondrial dysfunction, senescence, decline stem function.

Language: Английский

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Oncogenic Roles of the PI3K/AKT/mTOR Axis

Current topics in microbiology and immunology, Journal Year: 2017, Volume and Issue: unknown, P. 153 - 189

Published: Jan. 1, 2017

Language: Английский

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New frontiers in translational control of the cancer genome

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(5), P. 288 - 304

Published: April 26, 2016

Language: Английский

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