Epigenetics in NAFLD/NASH: Targets and therapy DOI
Nalini Sodum, Gautam Kumar, Sree Lalitha Bojja

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 167, P. 105484 - 105484

Published: March 24, 2021

Language: Английский

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis DOI
Aleksandra Deczkowska, Eyal David, Pierluigi Ramadori

et al.

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(6), P. 1043 - 1054

Published: May 20, 2021

Language: Английский

Citations

144
CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells DOI Creative Commons
Yuzo Koda,

Toshiaki Teratani,

Po–Sung Chu

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: July 22, 2021

Abstract Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can progress to fibrosis. Recent clinical advance suggests reversibility fibrosis, but the cellular and molecular mechanisms underlying NASH resolution remain unclarified. Here, using murine diet-induced subsequent model, we demonstrate direct roles CD8 + tissue-resident memory T (CD8 Trm) cells in resolving Single-cell transcriptome analysis FACS revealed CD69 CD103 − Trm cell enrichment livers. The reduction cells, maintained by tissue IL-15, significantly delayed fibrosis resolution, while adoptive transfer these protected mice from progression. During attracted hepatic stellate (HSCs) CCR5-dependent manner, predisposed activated HSCs FasL-Fas-mediated apoptosis. Histological assessment patients with abundance fibrotic areas, further supporting their humans. These results highlight undefined role resolution.

Language: Английский

Citations

134
Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes DOI
Zhiqiang Mao, Jianhua Xiong, Pengzhan Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 454, P. 214356 - 214356

Published: Dec. 14, 2021

Language: Английский

Citations

126
Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study DOI Creative Commons
Shuai Yuan, Jie Chen, Xue Li

et al.

European Journal of Epidemiology, Journal Year: 2022, Volume and Issue: 37(7), P. 723 - 733

Published: April 30, 2022

Abstract The risk factors for nonalcoholic fatty liver disease (NAFLD) have not been clearly identified. We conducted a Mendelian randomization (MR) study to explore this. Independent genetic variants strongly associated with 5 lifestyle and 9 metabolic were selected as instrumental variables from corresponding genome-wide association studies (GWASs). Summary-level data NAFLD obtained GWAS meta-analysis of 8434 cases 770,180 non-cases (discovery dataset) another 1483 17,781 (replication dataset). Univariable multivariable MR analyses performed. There associations lifetime smoking index (odds ratio (OR) 1.59, 95% confidence interval (CI) 1.31–1.93 per SD-increase), body mass (BMI, OR 1.33, CI 1.23–1.43 waist circumference (OR 1.82; 1.48–2.24 type 2 diabetes 1.21, 1.15–1.27 unit increase in log-transformed odds), systolic blood pressure 1.17; 1.07–1.26 10 mmHg increase), high-density lipoprotein cholesterol 0.84, 0.77–0.90 triglycerides 1.23, 1.15–1.33 SD-increase). diabetes, pressure, triglycerides, but remained strong after adjusting genetically-predicted BMI. Genetic liability mediated 51.4% (95% 13.4–89.3%) the BMI-effects on risk. suggestive inverse alcohol, coffee, caffeine consumption, vigorous physical activity This identified several that may be causally implicated NAFLD.

Language: Английский

Citations

124
Epigenetics in NAFLD/NASH: Targets and therapy DOI
Nalini Sodum, Gautam Kumar, Sree Lalitha Bojja

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 167, P. 105484 - 105484

Published: March 24, 2021

Language: Английский

Citations

104