The Role of Oxidative Stress and Antioxidants in Liver Diseases

International Journal of Molecular Sciences, Journal Year: 2015, Volume and Issue: 16(11), P. 26087 - 26124

Published: Nov. 2, 2015

A complex antioxidant system has been developed in mammals to relieve oxidative stress. However, excessive reactive species derived from oxygen and nitrogen may still lead damage tissue organs. Oxidative stress considered as a conjoint pathological mechanism, it contributes initiation progression of liver injury. lot risk factors, including alcohol, drugs, environmental pollutants irradiation, induce liver, which turn results severe diseases, such alcoholic disease non-alcoholic steatohepatitis. Application antioxidants signifies rational curative strategy prevent cure diseases involving Although conclusions drawn clinical studies remain uncertain, animal have revealed the promising vivo therapeutic effect on diseases. Natural contained edible or medicinal plants often possess strong free radical scavenging abilities well anti-inflammatory action, are also supposed be basis other bioactivities health benefits. In this review, PubMed was extensively searched for literature research. The keywords searching were radicals, oxygen, species, anti-oxidative therapy, Chinese medicines, natural products, literature, ours, with therapy focus. Various factors that cause effects prevention treatment summarized, questioned, discussed.

Language: Английский

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Alcoholic liver disease

Nature Reviews Disease Primers, Journal Year: 2018, Volume and Issue: 4(1)

Published: Aug. 16, 2018

Language: Английский

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Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Molecular Aspects of Medicine, Journal Year: 2018, Volume and Issue: 65, P. 37 - 55

Published: Sept. 13, 2018

Language: Английский

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EASL Clinical Practice Guidelines: Management of alcohol-related liver disease

Journal of Hepatology, Journal Year: 2018, Volume and Issue: 69(1), P. 154 - 181

Published: April 6, 2018

Language: Английский

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Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

Cell, Journal Year: 2016, Volume and Issue: 166(2), P. 288 - 298

Published: July 1, 2016

Language: Английский

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Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia

Gastroenterology, Journal Year: 2016, Volume and Issue: 150(4), P. 785 - 790

Published: Feb. 25, 2016

Language: Английский

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Determinants of fibrosis progression and regression in NASH

Journal of Hepatology, Journal Year: 2017, Volume and Issue: 68(2), P. 238 - 250

Published: Nov. 14, 2017

Language: Английский

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From NAFLD to MAFLD: Implications of a Premature Change in Terminology

Hepatology, Journal Year: 2020, Volume and Issue: 73(3), P. 1194 - 1198

Published: June 16, 2020

Despite the substantial gains in our understanding of NAFLD/NASH over past 2 decades, there has been some dissatisfaction with terminology "non-alcoholic" which overemphasizes "alcohol" and underemphasizes root cause this liver disease, namely, predisposing metabolic risk factors. As a potential remedy, name change from NAFLD to associated fatty disease (MAFLD) proposed. Although MAFLD reflects relevant factors for term is still suboptimal, leaving great deal ambiguity. Here, we caution that changing without its broad implications can have negative impact on field. In context, new molecular basis entity, insights stratification or other important aspect create unnecessary confusion could negatively At time when field facing challenges around awareness as well clarity acceptable endpoints drug development biomarker discovery, one suboptimal another full assessment expected deepen these challenges. context debate about terminology, recommend creation true international consensus group include all scientific societies (AASLD, EASL, ALEH, APASL), patient advocacy organizations, bio-pharmaceutical industry, regulatory agencies policy makers. A meeting must assess consequences based available evidence make recommendations will move forward. By approach, collaborative inclusive be adopted by stakeholders dealing global disease.

Language: Английский

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Acute-on-chronic liver failure: terminology, mechanisms and management

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2016, Volume and Issue: 13(3), P. 131 - 149

Published: Feb. 3, 2016

Language: Английский

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Alcohol Consumption and Risk of Liver Cirrhosis: A Systematic Review and Meta-Analysis

The American Journal of Gastroenterology, Journal Year: 2019, Volume and Issue: 114(10), P. 1574 - 1586

Published: Aug. 20, 2019

OBJECTIVES: To systematically summarize the risk relationship between different levels of alcohol consumption and incidence liver cirrhosis. METHODS: MEDLINE Embase were searched up to March 6, 2019, identify case–control cohort studies with sex-specific results more than 2 categories drinking in relation Study characteristics extracted random-effects meta-analyses meta-regressions conducted. RESULTS: A total 7 met inclusion criteria, providing data from 2,629,272 participants 5,505 cases There was no increased for occasional drinkers. Consumption one drink per day comparison long-term abstainers showed an cirrhosis women, but not men. The women consistently higher compared Drinking ≥5 drinks associated a substantially both (relative [RR] = 12.44, 95% confidence interval [CI]: 6.65–23.27 5–6 drinks, RR 24.58, CI: 14.77–40.90 ≥7 drinks) men (RR 3.80, 0.85–17.02, 6.93, 1.07–44.99, respectively). Heterogeneity across indicated additional impact other factors. DISCUSSION: Alcohol is major factor increasing exponentially. Women may be at even little consumption. More high-quality research necessary elucidate role factors, such as genetic vulnerability, body weight, metabolic patterns over life course. High should avoided, people high receive interventions reduce their intake.

Language: Английский

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