Lytic cell death in metabolic liver disease

Journal of Hepatology, Journal Year: 2020, Volume and Issue: 73(2), P. 394 - 408

Published: April 13, 2020

Language: Английский

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Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury

Cell Research, Journal Year: 2019, Volume and Issue: 29(12), P. 1009 - 1026

Published: Oct. 18, 2019

Language: Английский

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Alcoholic Hepatitis: A Review

Alcohol and Alcoholism, Journal Year: 2019, Volume and Issue: 54(4), P. 408 - 416

Published: April 9, 2019

Alcoholic liver disease (ALD) represents a spectrum of injury, ranging from simple steatosis to alcoholic hepatitis cirrhosis. Regular alcohol use results in fatty changes the which can develop into inflammation, fibrosis and ultimately cirrhosis with continued, excessive drinking. (AH) is an acute hepatic inflammation associated significant morbidity mortality that occur patients or underlying The pathogenesis ALD multifactorial addition genetic factors, alcohol-induced hepatocyte damage, reactive oxygen species, gut-derived microbial components result inflammatory cell (macrophage neutrophil leukocyte) recruitment activation liver. Continued pro-inflammatory cytokines induce stellate progressive fibrosis. Other than cessation use, medical therapy AH limited prednisolone subset patients. Given high nature ALD, there major need for new therapeutic intervention this underserved patient population.

Language: Английский

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Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 774 - 774

Published: Jan. 11, 2022

Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in owing to excessive alcohol consumption. Currently, ALD a leading cause for transplantation. Therefore, extensive studies (in vitro, experimental models humans) are needed elucidate pathological features pathogenic mechanisms underlying ALD. Notably, oxidative changes have been recognized as signature trait of Progression linked generation highly reactive free radicals reactions involving ethanol its metabolites. Furthermore, hepatic stress promotes tissue injury and, turn, stimulates inflammatory responses liver, forming loop that progression Accordingly, accumulating further knowledge on relationship between inflammation may help establish viable therapeutic approach treating

Language: Английский

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Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 454, P. 214356 - 214356

Published: Dec. 14, 2021

Language: Английский

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