NF-κB, inflammation, immunity and cancer: coming of age

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(5), P. 309 - 324

Published: Jan. 22, 2018

Language: Английский

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

European Journal of Immunology, Journal Year: 2019, Volume and Issue: 49(10), P. 1457 - 1973

Published: Oct. 1, 2019

These guidelines are a consensus work of considerable number members the immunology and flow cytometry community. They provide theory key practical aspects enabling immunologists to avoid common errors that often undermine immunological data. Notably, there comprehensive sections all major immune cell types with helpful Tables detailing phenotypes in murine human cells. The latest techniques applications also described, featuring examples data can be generated and, importantly, how analysed. Furthermore, tips, tricks pitfalls avoid, written peer-reviewed by leading experts field, making this an essential research companion.

Language: Английский

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Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

Nature, Journal Year: 2019, Volume and Issue: 577(7790), P. 410 - 415

Published: Dec. 25, 2019

Language: Английский

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Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

Gastroenterology, Journal Year: 2016, Volume and Issue: 152(2), P. 327 - 339.e4

Published: Oct. 18, 2016

Language: Английский

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Antibiotics as Major Disruptors of Gut Microbiota

Frontiers in Cellular and Infection Microbiology, Journal Year: 2020, Volume and Issue: 10

Published: Nov. 24, 2020

Advances in culture-independent research techniques have led to an increased understanding of the gut microbiota and role it plays health disease. The intestine is populated by a complex microbial community that organized around network metabolic interdependencies. It now understood vital for normal development functioning human body, especially priming maturation adaptive immune system. Antibiotic use can several negative effects on microbiota, including reduced species diversity, altered activity, selection antibiotic-resistant organisms, which turn lead antibiotic-associated diarrhea recurrent Clostridioides difficile infections. There also evidence early childhood exposure antibiotics gastrointestinal, immunologic, neurocognitive conditions. increase recent years suggests these problems are likely become more acute or prevalent future. Continued into structure function required address this challenge.

Language: Английский

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Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

Nature Reviews Microbiology, Journal Year: 2018, Volume and Issue: 16(8), P. 457 - 470

Published: June 14, 2018

Language: Английский

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Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine

Annual Review of Immunology, Journal Year: 2020, Volume and Issue: 38(1), P. 23 - 48

Published: April 26, 2020

The gastrointestinal tract harbors numerous commensal bacteria, referred to as the microbiota, that benefit host health by digesting dietary components and eliminating pathogens. intestinal microbiota maintains epithelial barrier integrity shapes mucosal immune system, balancing defense oral tolerance with microbial metabolites, components, attachment cells. To avoid aberrant responses, cells segregate from constructing chemical physical barriers, leading establishment of host-commensal mutualism. Furthermore, participate in maintenance a healthy community reinforce functions. Perturbations composition are commonly observed patients autoimmune diseases chronic inflammatory disorders. An understanding intimate interactions between cells, crucial for homeostasis might promote advances diagnostic therapeutic approaches various diseases.

Language: Английский

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T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

Cell, Journal Year: 2018, Volume and Issue: 175(5), P. 1307 - 1320.e22

Published: Nov. 1, 2018

Language: Английский

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Interleukin-18 in Health and Disease

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(3), P. 649 - 649

Published: Feb. 2, 2019

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing which increase response to stimulation. Therefore, IL-12 is commitment induces development cells. In contrast, proinflammatory cytokine facilitates type 1 responses. However, without but IL-2, stimulates NK CD4+ NKT and established produce IL-3, IL-9, IL-13. Furthermore, together mast basophils IL-4, IL-13, chemical mediators such histamine. various cell types has pleiotropic functions. member IL-1 family cytokines. demonstrates unique function by binding specific expressed on this review article, we will focus features health disease experimental animals humans.

Language: Английский

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Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: Aug. 15, 2018

The microbiota consists of a dynamic multispecies community bacteria, fungi, archaea and protozoans, bringing to the host organism dowry cells genes more numerous than its own. Among different non-sterile cavities, human gut harbors most complex microbiota, with strong impact on homeostasis immunostasis, being thus essential for maintaining health condition. In this review we outline roles in immunity, starting background information supporting further presentation implications dysbiosis susceptibility infections, hypersensitivity reactions, autoimmunity, chronic inflammation cancer. role diet antibiotics occurrence pathological consequences, as well potential probiotics restore eubiosis is also discussed.

Language: Английский

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