Mutations,
deletions,
and
changes
in
copy
number
of
mitochondrial
DNA
(mtDNA),
are
observed
throughout
cancers.
Here,
we
survey
mtDNA
variation
across
22
tumor
types
profiled
by
The
Cancer
Genome
Atlas
project.
We
observe
a
tendency
for
some
cancers,
especially
the
bladder,
breast,
kidney,
to
be
depleted
mtDNA,
relative
matched
normal
tissue.
Analysis
genetic
context
reveals
an
association
between
incidence
several
somatic
alterations,
including
IDH1
mutations
gliomas,
content.
In
but
not
all
cancer
types,
content
is
correlated
with
expression
respiratory
genes,
anti-correlated
immune
response
cell-cycle
genes.
tandem
immunohistochemical
evidence,
find
that
tumors
may
compensate
depletion
sustain
levels
proteins.
Our
results
highlight
extent
point
related
therapeutic
opportunities.
Trends in Plant Science,
Journal Year:
2016,
Volume and Issue:
22(1), P. 11 - 19
Published: Sept. 24, 2016
Reactive
oxygen
species
(ROS)
are
thought
to
play
a
dual
role
in
plant
biology.
They
required
for
many
important
signaling
reactions,
but
also
toxic
byproducts
of
aerobic
metabolism.
Recent
studies
revealed
that
ROS
necessary
the
progression
several
basic
biological
processes
including
cellular
proliferation
and
differentiation.
Moreover,
cell
death-that
was
previously
be
outcome
directly
killing
cells
by
oxidation,
other
words
via
oxidative
stress-is
now
considered
result
triggering
physiological
or
programmed
pathway
death.
This
Opinion
focuses
on
possibility
beneficial
plants,
supporting
proliferation,
function,
viability,
maintaining
basal
level
is
essential
life.
Redox Biology,
Journal Year:
2015,
Volume and Issue:
6, P. 472 - 485
Published: Sept. 12, 2015
Reactive
oxygen
species
(ROS)
are
integral
components
of
multiple
cellular
pathways
even
though
excessive
or
inappropriately
localized
ROS
damage
cells.
function
as
anti-microbial
effector
molecules
and
signaling
that
regulate
such
processes
NF-kB
transcriptional
activity,
the
production
DNA-based
neutrophil
extracellular
traps
(NETs),
autophagy.
The
main
sources
mitochondria
NADPH
oxidases
(NOXs).
In
contrast
to
NOX-generated
ROS,
produced
in
(mtROS)
were
initially
considered
be
unwanted
by-products
oxidative
metabolism.
Increasing
evidence
indicates
mtROS
have
been
incorporated
into
including
those
regulating
immune
responses
As
metabolic
hubs,
facilitate
crosstalk
between
state
cell
with
these
pathways.
Mitochondria
thus
a
nexus
determine
response
cells
disruptions
homeostasis
infection,
sterile
damage,
imbalance.
this
review,
we
discuss
roles
generation
ROS-derived
effectors,
interplay
autophagy
formation
DNA
traps,
activation
NLRP3
inflammasome
by
mitochondria.
Journal of Hematology & Oncology,
Journal Year:
2013,
Volume and Issue:
6(1)
Published: Feb. 25, 2013
Abstract
There
are
multiple
sources
of
reactive
oxygen
species
(ROS)
in
the
cell.
As
a
major
site
ROS
production,
mitochondria
have
drawn
considerable
interest
because
it
was
recently
discovered
that
mitochondrial
(mtROS)
directly
stimulate
production
proinflammatory
cytokines
and
pathological
conditions
as
diverse
malignancies,
autoimmune
diseases,
cardiovascular
diseases
all
share
common
phenotype
increased
mtROS
above
basal
levels.
Several
excellent
reviews
on
this
topic
been
published,
but
ever-changing
new
discoveries
mandated
more
up-to-date
comprehensive
review
topic.
Therefore,
we
update
recent
understanding
how
generate
regulate
function
both
physiological
conditions.
In
addition,
describe
newly
developed
methods
to
probe
or
scavenge
compare
these
detail.
Thorough
application
mtROS-targeting
drugs
research
is
significant
towards
development
better
therapies
combat
inflammatory
malignancies.
