Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

Nature reviews. Neuroscience, Journal Year: 2014, Volume and Issue: 15(4), P. 233 - 249

Published: March 12, 2014

Language: Английский

---

Acute Kidney Injury

Annual Review of Medicine, Journal Year: 2016, Volume and Issue: 67(1), P. 293 - 307

Published: Jan. 14, 2016

Acute kidney injury (AKI) is a global public health concern associated with high morbidity, mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably improve survival, limit injury, or speed recovery. Despite recognized shortcomings of in vivo animal models, the underlying pathophysiology AKI its consequence, chronic disease (CKD), rich biological targets. We review recent findings relating to renal vasculature cellular stress responses, primarily intersection unfolded protein response, mitochondrial dysfunction, autophagy, innate immune response. Maladaptive repair mechanisms that persist following acute phase promote inflammation fibrosis phase. Here macrophages, growth-arrested tubular epithelial cells, endothelium, surrounding pericytes are key players progression disease. Better understanding these complex interacting pathophysiological mechanisms, their relative importance humans, utility biomarkers will lead strategies prevent treat impede CKD end-stage (ESRD).

Language: Английский

---

Therapy for Fibrotic Diseases: Nearing the Starting Line

Science Translational Medicine, Journal Year: 2013, Volume and Issue: 5(167)

Published: Jan. 9, 2013

An emerging consensus indicates that fibrotic diseases in lung, liver, and kidney exhibit common underlying mechanisms, which can be targeted therapeutically.

Language: Английский

---

Stress granules and cell signaling: more than just a passing phase?

Trends in Biochemical Sciences, Journal Year: 2013, Volume and Issue: 38(10), P. 494 - 506

Published: Sept. 10, 2013

Language: Английский

---

Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

Nature reviews. Cancer, Journal Year: 2014, Volume and Issue: 14(4), P. 263 - 276

Published: March 24, 2014

Language: Английский

---