Circulation Research,
Journal Year:
2014,
Volume and Issue:
114(3), P. 572 - 586
Published: Jan. 30, 2014
Integrins
are
heterodimeric,
transmembrane
receptors
that
expressed
in
all
cells,
including
those
the
heart.
They
participate
multiple
critical
cellular
processes
adhesion,
extracellular
matrix
organization,
signaling,
survival,
and
proliferation.
Particularly
relevant
for
a
contracting
muscle
cell,
integrins
mechanotransducers,
translating
mechanical
to
biochemical
information.
Although
it
is
likely
cardiovascular
clinicians
scientists
have
highest
recognition
of
system
from
drugs
used
inhibit
platelet
aggregation,
focus
this
article
will
be
on
role
specifically
cardiac
myocyte.
After
general
introduction
integrin
biology,
discuss
important
work
mechanotransduction,
lessons
learned
about
function
range
model
organisms.
Then
we
detail
integrin-related
proteins
myocyte,
how
may
interact
with
ion
channels
mediate
viral
uptake
into
also
play
stem
cell
biology.
Finally,
directions
future
study.
Cellular and Molecular Life Sciences,
Journal Year:
2014,
Volume and Issue:
71(22), P. 4373 - 4386
Published: July 30, 2014
Cellular
senescence,
a
permanent
state
of
cell
cycle
arrest
accompanied
by
complex
phenotype,
is
an
essential
mechanism
that
limits
tumorigenesis
and
tissue
damage.
In
physiological
conditions,
senescent
cells
can
be
removed
the
immune
system,
facilitating
tumor
suppression
wound
healing.
However,
as
we
age,
accumulate
in
tissues,
either
because
aging
system
fails
to
remove
them,
rate
formation
elevated,
or
both.
If
persist
they
have
potential
paradoxically
promote
pathological
conditions.
senescence
associated
with
enhanced
pro-survival
which
most
likely
promotes
persistence
vivo.
This
phenotype
may
evolved
favor
facilitation
short-term
healing,
followed
elimination
system.
this
review,
provide
perspective
on
triggers,
mechanisms
well
consequences
cells.
BioMed Research International,
Journal Year:
2014,
Volume and Issue:
2014, P. 1 - 18
Published: Jan. 1, 2014
In
tissue
engineering
and
regenerative
medicine,
the
conditions
in
immediate
vicinity
of
cells
have
a
direct
effect
on
cells’
behaviour
subsequently
clinical
outcomes.
Physical,
chemical,
biological
control
cell
microenvironment
are
crucial
importance
for
ability
to
3-dimensional
scaffolds
spatially
temporally.
this
review,
we
will
focus
different
aspects
such
as
surface
micro-,
nanotopography,
extracellular
matrix
composition
distribution,
controlled
release
soluble
factors,
mechanical
stress/strain
how
these
their
interactions
can
be
used
achieve
higher
degree
over
cellular
activities.
The
parameters
within
context
is
discussed
develop
engineered
tissues
elaborated.
Also,
recent
techniques
developed
monitoring
vitro
vivo
reviewed,
together
with
applications
where
has
been
exploited.
Cell
parts
efforts
systems
which
utilize
components
simultaneously
provide
more
functional
near
future.
Journal of Cell Science,
Journal Year:
2014,
Volume and Issue:
unknown
Published: Jan. 1, 2014
How
cells
respond
to
physical
cues
in
order
meet
and
withstand
the
demands
of
their
immediate
surroundings
has
been
great
interest
for
many
years,
with
current
research
efforts
focused
on
mechanisms
that
transduce
signals
into
gene
expression.
Pathways
mechano-regulate
entry
transcription
factors
cell
nucleus
are
emerging,
our
most
recent
studies
show
mechanical
properties
itself
actively
controlled
response
elasticity
extracellular
matrix
(ECM)
both
mature
developing
tissue.
In
this
Commentary,
we
review
mechano-responsive
nuclei
as
determined
by
intermediate
filament
lamin
proteins
line
inside
nuclear
envelope
also
impact
upon
factor
broader
epigenetic
mechanisms.
We
summarize
signaling
pathways
regulate
levels
cell-fate
decisions
a
combination
ECM
mechanics
molecular
cues.
will
discuss
work
highlights
importance
niche
anchorage
motility
during
development,
hematopoietic
differentiation
cancer
metastasis,
well
emphasizing
role
protecting
chromatin
from
stress-induced
damage.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(49)
Published: July 31, 2018
Abstract
Stem
cells
hold
great
promise
for
widespread
biomedical
applications,
which
stem
cell
fate
needs
to
be
well
tailored.
Besides
biochemical
cues,
accumulating
evidence
has
demonstrated
that
spatiotemporal
biophysical
cues
(especially
mechanical
cues)
imposed
by
microenvironments
also
critically
impact
on
the
fate.
As
such,
various
biomaterials,
especially
hydrogels
due
their
tunable
physicochemical
properties
and
advanced
fabrication
approaches,
are
developed
spatiotemporally
manipulate
in
vitro
so
as
recapitulate
3D
microenvironment
where
reside
vivo.
Here,
main
experience
native
summarized.
Then,
recent
advances
design
of
hydrogel
materials
with
engineering
highlighted.
These
engineered
crucial
guiding
potential
applications
subsequently
discussed.
Finally,
challenges
future
perspectives
presented.
Circulation Research,
Journal Year:
2014,
Volume and Issue:
114(3), P. 572 - 586
Published: Jan. 30, 2014
Integrins
are
heterodimeric,
transmembrane
receptors
that
expressed
in
all
cells,
including
those
the
heart.
They
participate
multiple
critical
cellular
processes
adhesion,
extracellular
matrix
organization,
signaling,
survival,
and
proliferation.
Particularly
relevant
for
a
contracting
muscle
cell,
integrins
mechanotransducers,
translating
mechanical
to
biochemical
information.
Although
it
is
likely
cardiovascular
clinicians
scientists
have
highest
recognition
of
system
from
drugs
used
inhibit
platelet
aggregation,
focus
this
article
will
be
on
role
specifically
cardiac
myocyte.
After
general
introduction
integrin
biology,
discuss
important
work
mechanotransduction,
lessons
learned
about
function
range
model
organisms.
Then
we
detail
integrin-related
proteins
myocyte,
how
may
interact
with
ion
channels
mediate
viral
uptake
into
also
play
stem
cell
biology.
Finally,
directions
future
study.
