Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Cell Death and Differentiation, Journal Year: 2018, Volume and Issue: 25(3), P. 486 - 541

Published: Jan. 23, 2018

Over the past decade, Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for definition and interpretation of cell death from morphological, biochemical, functional perspectives. Since field continues to expand novel mechanisms that orchestrate multiple pathways are unveiled, we propose an updated classification subroutines focusing mechanistic essential (as opposed correlative dispensable) aspects process. As provide molecularly oriented definitions terms including intrinsic apoptosis, extrinsic mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic death, NETotic lysosome-dependent autophagy-dependent immunogenic cellular senescence, mitotic catastrophe, discuss utility neologisms refer highly specialized instances these processes. The mission NCCD is a widely accepted nomenclature in support continued development field.

Language: Английский

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Nature Cell Biology, Journal Year: 2014, Volume and Issue: 16(12), P. 1180 - 1191

Published: Nov. 17, 2014

Language: Английский

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ROS Are Good

Trends in Plant Science, Journal Year: 2016, Volume and Issue: 22(1), P. 11 - 19

Published: Sept. 24, 2016

Reactive oxygen species (ROS) are thought to play a dual role in plant biology. They required for many important signaling reactions, but also toxic byproducts of aerobic metabolism. Recent studies revealed that ROS necessary the progression several basic biological processes including cellular proliferation and differentiation. Moreover, cell death-that was previously be outcome directly killing cells by oxidation, other words via oxidative stress-is now considered result triggering physiological or programmed pathway death. This Opinion focuses on possibility beneficial plants, supporting proliferation, function, viability, maintaining basal level is essential life.

Language: Английский

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Ferroptosis: molecular mechanisms and health implications

Cell Research, Journal Year: 2020, Volume and Issue: 31(2), P. 107 - 125

Published: Dec. 2, 2020

Abstract Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form non-apoptotic cell in 2012, there has been mounting interest process and function ferroptosis. Ferroptosis occur two major pathways, extrinsic or transporter-dependent pathway intrinsic enzyme-regulated pathway. is caused by a redox imbalance between production oxidants antioxidants, which driven abnormal expression activity multiple redox-active enzymes that produce detoxify free radicals lipid oxidation products. Accordingly, precisely regulated at levels, including epigenetic, transcriptional, posttranscriptional posttranslational layers. The transcription factor NFE2L2 plays central role upregulating anti-ferroptotic defense, whereas selective autophagy may promote ferroptotic death. Here, we review current knowledge on integrated molecular machinery describe how dysregulated involved cancer, neurodegeneration, tissue injury, inflammation, infection.

Language: Английский

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NF-κB, inflammation, immunity and cancer: coming of age

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(5), P. 309 - 324

Published: Jan. 22, 2018

Language: Английский

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The molecular machinery of regulated cell death

Cell Research, Journal Year: 2019, Volume and Issue: 29(5), P. 347 - 364

Published: April 4, 2019

Cells may die from accidental cell death (ACD) or regulated (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms have been identified are increasingly being implicated in various human pathologies. Here, we critically review the current state art regarding types RCD, including necroptosis, pyroptosis, ferroptosis, entotic death, netotic parthanatos, lysosome-dependent autophagy-dependent alkaliptosis oxeiptosis. The in-depth comprehension each these lethal subroutines their intercellular consequences uncover therapeutic targets for avoidance pathogenic loss.

Language: Английский

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Targeting Ferroptosis to Iron Out Cancer

Cancer Cell, Journal Year: 2019, Volume and Issue: 35(6), P. 830 - 849

Published: May 16, 2019

Language: Английский

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Necroptosis and its role in inflammation

Nature, Journal Year: 2015, Volume and Issue: 517(7534), P. 311 - 320

Published: Jan. 13, 2015

Language: Английский

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Glutaminolysis and Transferrin Regulate Ferroptosis

Molecular Cell, Journal Year: 2015, Volume and Issue: 59(2), P. 298 - 308

Published: July 1, 2015

Language: Английский

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Ferroptosis is an autophagic cell death process

Cell Research, Journal Year: 2016, Volume and Issue: 26(9), P. 1021 - 1032

Published: Aug. 12, 2016

Language: Английский

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