Identification of ACSL4 as a biomarker and contributor of ferroptosis

Biochemical and Biophysical Research Communications, Journal Year: 2016, Volume and Issue: 478(3), P. 1338 - 1343

Published: Aug. 25, 2016

Language: Английский

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Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Nature Chemical Biology, Journal Year: 2016, Volume and Issue: 12(7), P. 497 - 503

Published: May 9, 2016

Language: Английский

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Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

ACS Chemical Biology, Journal Year: 2015, Volume and Issue: 10(7), P. 1604 - 1609

Published: May 12, 2015

Little is known about the regulation of nonapoptotic cell death. Using massive insertional mutagenesis haploid KBM7 cells we identified nine genes involved in small-molecule-induced death, including mediators fatty acid metabolism (ACSL4) and lipid remodeling (LPCAT3) ferroptosis. One novel compound, CIL56, triggered death dependent upon rate-limiting de novo synthetic enzyme ACC1. These results provide insight into genetic highlight central role

Language: Английский

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Ferroptosis is a type of autophagy-dependent cell death

Seminars in Cancer Biology, Journal Year: 2019, Volume and Issue: 66, P. 89 - 100

Published: March 14, 2019

Language: Английский

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Resolution of inflammation: a new therapeutic frontier

Nature Reviews Drug Discovery, Journal Year: 2016, Volume and Issue: 15(8), P. 551 - 567

Published: March 29, 2016

Language: Английский

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