Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(7), P. 363 - 383

Published: March 30, 2020

Language: Английский

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Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

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Oxidative Stress in Cancer

Cancer Cell, Journal Year: 2020, Volume and Issue: 38(2), P. 167 - 197

Published: July 9, 2020

Language: Английский

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Oxidative stress and autophagy: the clash between damage and metabolic needs

Cell Death and Differentiation, Journal Year: 2014, Volume and Issue: 22(3), P. 377 - 388

Published: Sept. 26, 2014

Autophagy is a catabolic process aimed at recycling cellular components and damaged organelles in response to diverse conditions of stress, such as nutrient deprivation, viral infection genotoxic stress. A growing amount evidence recent years argues for oxidative stress acting the converging point these stimuli, with reactive oxygen species (ROS) nitrogen (RNS) being among main intracellular signal transducers sustaining autophagy. This review aims providing novel insight into regulatory pathways autophagy glucose amino acid well their tight interconnection metabolic networks redox homeostasis. The role nitrosative also discussed light its harmful both biomolecules mediator through reversible posttranslational modifications thiol-containing proteins. redox-independent relationship between antioxidant response, occurring p62/Keap1/Nrf2 pathway, addressed order provide wide perspective upon Herein, we attempt afford an overview complex crosstalk DNA damage (DDR), focusing on activated ROS RNS overproduction. Along lines, direct indirect DDR dissected depth.

Language: Английский

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ROS in cancer therapy: the bright side of the moon

Experimental & Molecular Medicine, Journal Year: 2020, Volume and Issue: 52(2), P. 192 - 203

Published: Feb. 1, 2020

Abstract Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators important signaling pathways. It is now well accepted moderate levels ROS are required for several cellular functions, including gene expression. The production elevated in tumor cells consequence increased metabolic rate, mutation and relative hypoxia, excess quenched by antioxidant enzymatic nonenzymatic pathways the same cells. Moderate increases contribute to pathologic conditions, among which promotion progression, they involved different induce DNA mutation. However, also able trigger programmed cell death (PCD). Our review will emphasize molecular mechanisms useful development therapeutic strategies based on modulating treat cancer. Specifically, we report growing data highlight role generated Trojan horses eliminate cancer

Language: Английский

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Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

Redox Biology, Journal Year: 2017, Volume and Issue: 11, P. 613 - 619

Published: Jan. 5, 2017

Hydrogen peroxide emerged as major redox metabolite operative in sensing, signaling and regulation. Generation, transport capture of H2O2 biological settings well their consequences can now be addressed. The present overview focuses on recent progress metabolic sources sinks the role under physiological conditions (1–10 nM), denoted oxidative eustress. Higher concentrations lead to adaptive stress responses via master switches such Nrf2/Keap1 or NF-κB. Supraphysiological (>100 nM) damage biomolecules, distress. Three questions are addressed: How assayed setting? What H2O2? is stress?

Language: Английский

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Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

The Journal of Cell Biology, Journal Year: 2018, Volume and Issue: 217(6), P. 1915 - 1928

Published: April 18, 2018

Superoxide dismutases (SODs) are universal enzymes of organisms that live in the presence oxygen. They catalyze conversion superoxide into oxygen and hydrogen peroxide. anions intended product dedicated signaling as well byproduct several metabolic processes including mitochondrial respiration. Through their activity, SOD control levels a variety reactive species (ROS) nitrogen species, thus both limiting potential toxicity these molecules controlling broad aspects cellular life regulated by functions. All aerobic have multiple proteins targeted to different subcellular locations, reflecting slow diffusion sources substrate superoxide. This compartmentalization also points need for fine local ROS possibility signal between compartments. In this review, we discuss studies model humans, which reveal dual roles damage regulating signaling.

Language: Английский

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ROS signalling in the biology of cancer

Seminars in Cell and Developmental Biology, Journal Year: 2017, Volume and Issue: 80, P. 50 - 64

Published: June 4, 2017

Language: Английский

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Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

Journal of Alzheimer s Disease, Journal Year: 2017, Volume and Issue: 57(4), P. 1105 - 1121

Published: Jan. 6, 2017

Alzheimer's disease (AD) is a devastating neurodegenerative disorder without cure. Most AD cases are sporadic where age represents the greatest risk factor. Lack of understanding mechanism hinders development efficacious therapeutic approaches. The loss synapses in affected brain regions correlates best with cognitive impairment patients and has been considered as early that precedes neuronal loss. Oxidative stress recognized contributing factor aging progression multiple diseases including AD. Increased production reactive oxygen species (ROS) associated age- disease-dependent mitochondrial function, altered metal homeostasis, reduced antioxidant defense directly affect synaptic activity neurotransmission neurons leading to dysfunction. In addition, molecular targets by ROS include nuclear DNA, lipids, proteins, calcium dynamics cellular architecture, receptor trafficking endocytosis, energy homeostasis. Abnormal metabolism turn could accumulation amyloid-β (Aβ) hyperphosphorylated Tau protein, which independently exacerbate dysfunction production, thereby vicious cycle. While mounting evidence implicates etiology, clinical trials therapies have not produced consistent results. this review, we will discuss role oxidative AD, innovative strategies evolved based on better complexity mechanisms dual play health disease.

Language: Английский

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NRF2 and the Hallmarks of Cancer

Cancer Cell, Journal Year: 2018, Volume and Issue: 34(1), P. 21 - 43

Published: May 3, 2018

Language: Английский

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