Regulation and Role of Fungal Secondary Metabolites

Annual Review of Genetics, Journal Year: 2016, Volume and Issue: 50(1), P. 371 - 392

Published: Oct. 12, 2016

Fungi have the capability to produce a tremendous number of so-called secondary metabolites, which possess multitude functions, e.g., communication signals during coexistence with other microorganisms, virulence factors pathogenic interactions plants and animals, in medical applications. Therefore, research on this topic has intensified significantly past 10 years thus knowledge regulatory mechanisms understanding role metabolites drastically increased. This review aims depict complexity all elements involved controlling expression metabolite gene clusters, ranging from epigenetic control signal transduction pathways global specific transcriptional regulators. Furthermore, we give short overview focusing interaction microorganisms environment as well relationships.

Language: Английский

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Splicing and transcription touch base: co-transcriptional spliceosome assembly and function

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(10), P. 637 - 650

Published: Aug. 9, 2017

Language: Английский

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The roles of histone variants in fine-tuning chromatin organization and function

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(9), P. 522 - 541

Published: July 14, 2020

Language: Английский

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Starch as a source, starch as a sink: the bifunctional role of starch in carbon allocation

Journal of Experimental Botany, Journal Year: 2017, Volume and Issue: 68(16), P. 4433 - 4453

Published: July 20, 2017

Starch commands a central role in the carbon budget of majority plants on earth, and its biological changes during development response to environment. Throughout life plant, starch plays dual allocation, acting as both source, releasing reserves leaves for growth development, sink, either dedicated store own right (in seeds tubers), or temporary reserve contributing sink strength, organs such flowers, fruits, developing non-starchy seeds. The presence tissues thus has profound impact physiology growing plant synthesis degradation governs availability free sugars, which turn control various developmental processes. This review attempts summarize large body information currently available metabolism relationship wider aspects nutrition. It highlights gaps our knowledge points research areas that show promise bioengineering manipulation order achieve more desirable phenotypes increased yield biomass.

Language: Английский

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The role of extracellular histone in organ injury

Cell Death and Disease, Journal Year: 2017, Volume and Issue: 8(5), P. e2812 - e2812

Published: May 25, 2017

Abstract Histones are intra-nuclear cationic proteins that present in all eukaryotic cells and highly conserved across species. Within the nucleus, they provide structural stability to chromatin regulate gene expression. Histone may be released into extracellular space three forms: freely, as a DNA-bound nucleosome or part of neutrophil traps, can detected serum after significant cellular death such sepsis, trauma, ischaemia/reperfusion injury autoimmune disease. Once space, histones act damage-associated molecular pattern proteins, activating immune system causing further cytotoxicity. They interact with Toll-like receptors (TLRs), complement phospholipids cell membranes inducing endothelial epithelial cytotoxicity, TLR2/TLR4/TLR9 activation pro-inflammatory cytokine/chemokine release via MyD88, NFκB NLRP3 inflammasome-dependent pathways. Drugs block histone, neutralise circulating histone signal transduction protection from mortality animal models acute organ but warrant research inform future clinical applications.

Language: Английский

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Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing

Journal of Molecular Biology, Journal Year: 2016, Volume and Issue: 428(12), P. 2623 - 2635

Published: April 30, 2016

Language: Английский

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The emerging role of epigenetics in human autoimmune disorders

Clinical Epigenetics, Journal Year: 2019, Volume and Issue: 11(1)

Published: Feb. 26, 2019

Epigenetic pathways play a pivotal role in the development and function of immune system. Over last decade, growing body studies has been published out seeking to explain correlation between epigenetic modifications autoimmune disorders. changes, such as DNA methylation, histone modifications, noncoding RNAs, are involved pathogenesis diseases mainly by regulating gene expression. This paper reviews importance alterations during most prevalent human diseases, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), sclerosis (SSc), Sjogren's syndrome (SS), thyroid (AITD), type 1 diabetes (T1D), aiming provide new insights possibility develop novel therapeutic approaches targeting epigenome.

Language: Английский

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The epigenetic basis of cellular heterogeneity

Nature Reviews Genetics, Journal Year: 2020, Volume and Issue: 22(4), P. 235 - 250

Published: Nov. 26, 2020

Language: Английский

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Structural Basis of Heterochromatin Formation by Human HP1

Molecular Cell, Journal Year: 2018, Volume and Issue: 69(3), P. 385 - 397.e8

Published: Jan. 11, 2018

Language: Английский

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Epigenetic Modifications in Cardiovascular Aging and Diseases

Circulation Research, Journal Year: 2018, Volume and Issue: 123(7), P. 773 - 786

Published: Sept. 13, 2018

Aging is associated with a progressive decline in cardiovascular structure and function. Accumulating evidence links aging to epigenetic alterations encompassing complex interplay of DNA methylation, histone posttranslational modifications, dynamic nucleosome occupancy governed by numerous factors. Advances genomics technology have led profound understanding chromatin reorganization both diseases. This review summarizes recent discoveries mechanisms involved diseases discusses potential therapeutic strategies retard conquer related through the rejuvenation signatures young state.

Language: Английский

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