Transcriptional architecture of the mammalian circadian clock

Nature Reviews Genetics, Journal Year: 2016, Volume and Issue: 18(3), P. 164 - 179

Published: Dec. 19, 2016

Language: Английский

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Cohesin Loss Eliminates All Loop Domains

Cell, Journal Year: 2017, Volume and Issue: 171(2), P. 305 - 320.e24

Published: Oct. 1, 2017

Language: Английский

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Transcriptional Addiction in Cancer

Cell, Journal Year: 2017, Volume and Issue: 168(4), P. 629 - 643

Published: Feb. 1, 2017

Language: Английский

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Organizational principles of 3D genome architecture

Nature Reviews Genetics, Journal Year: 2018, Volume and Issue: 19(12), P. 789 - 800

Published: Oct. 26, 2018

Language: Английский

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Histone exchange, chromatin structure and the regulation of transcription

Nature Reviews Molecular Cell Biology, Journal Year: 2015, Volume and Issue: 16(3), P. 178 - 189

Published: Feb. 4, 2015

Language: Английский

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BRD4 and Cancer: going beyond transcriptional regulation

Molecular Cancer, Journal Year: 2018, Volume and Issue: 17(1)

Published: Nov. 22, 2018

BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role super-enhancers (SEs) organization oncogenes expression regulation. Inhibition BRD4 shortcuts communication between SEs target promoters with a subsequent cell-specific repression to which cells are addicted cell death. To date, this most credited mechanism action BET inhibitors, class small molecules targeting proteins currently clinical trials several settings. However, recent evidence indicates that relevance goes beyond transcription regulation identifies as keeper genome stability. Indeed, non-transcriptional controlling DNA damage checkpoint activation repair well telomere maintenance has been proposed, throwing new lights into multiple functions opening perspectives on use BETi cancer. Here we discuss current available information non-canonical, their implications biology. Integrating already known gene regulation, propose "common" model explain genomic function. Furthermore, light transversal function provide interpretation cytotoxic activity possibilities wide focused employment these drugs

Language: Английский

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Genomic encoding of transcriptional burst kinetics

Nature, Journal Year: 2018, Volume and Issue: 565(7738), P. 251 - 254

Published: Dec. 21, 2018

Language: Английский

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Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals

Molecular Cell, Journal Year: 2016, Volume and Issue: 63(1), P. 167 - 178

Published: July 1, 2016

Language: Английский

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Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

Genes & Development, Journal Year: 2019, Volume and Issue: 33(15-16), P. 960 - 982

Published: May 23, 2019

Precise spatio-temporal control of gene activity is essential for organismal development, growth, and survival in a changing environment. Decisive steps regulation involve the pausing RNA polymerase II (Pol II) early elongation, controlled release paused into productive synthesis. Here we describe factors that enable events trigger Pol gene. We also discuss open questions field concerning stability II, nucleosomes as obstacles to potential roles defining precision dynamics expression.

Language: Английский

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MYC: connecting selective transcriptional control to global RNA production

Nature reviews. Cancer, Journal Year: 2015, Volume and Issue: 15(10), P. 593 - 607

Published: Sept. 18, 2015

Language: Английский

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