Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era DOI
Helga U. van der Heul, Bohdan Bilyk, Kenneth J. McDowall

et al.

Natural Product Reports, Journal Year: 2018, Volume and Issue: 35(6), P. 575 - 604

Published: Jan. 1, 2018

Covering: 2000 to 2018 The antimicrobial activity of many their natural products has brought prominence the Streptomycetaceae, a family Gram-positive bacteria that inhabit both soil and aquatic sediments. In environment, compounds are likely limit growth competitors, thereby offering selective advantage producer, in particular when nutrients become limited developmental programme leading spores commences. study control this secondary metabolism continues offer insights into its integration with complex lifecycle takes multiple cues from environment primary metabolism. Such information can then be harnessed devise laboratory screening conditions discover new or improved clinical value. Here we provide an update review published NPR 2011. Besides providing essential background, focus on recent developments our understanding underlying regulatory networks, ecological triggers product biosynthesis, contributions comparative genomics approaches awaken biosynthesis otherwise silent cryptic products. addition, highlight discoveries antibiotic production other Actinobacteria, which have gained considerable attention since start revolution. New technologies potential produce step change regulation also described.

Language: Английский

Natural products in drug discovery: advances and opportunities DOI Open Access
Atanas G. Atanasov, Sergey B. Zotchev, Verena M. Dirsch

et al.

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(3), P. 200 - 216

Published: Jan. 28, 2021

Language: Английский

Citations

3491
Taxonomy, Physiology, and Natural Products of Actinobacteria DOI Open Access
Essaïd Ait Barka,

Parul Vatsa,

Lisa Sanchez

et al.

Microbiology and Molecular Biology Reviews, Journal Year: 2016, Volume and Issue: 80(1), P. 1 - 43

Published: March 1, 2016

SUMMARY Actinobacteria are Gram-positive bacteria with high G+C DNA content that constitute one of the largest bacterial phyla, and they ubiquitously distributed in both aquatic terrestrial ecosystems. Many have a mycelial lifestyle undergo complex morphological differentiation. They also an extensive secondary metabolism produce about two-thirds all naturally derived antibiotics current clinical use, as well many anticancer, anthelmintic, antifungal compounds. Consequently, these major importance for biotechnology, medicine, agriculture. play diverse roles their associations various higher organisms, since members adopted different lifestyles, phylum includes pathogens (notably, species Corynebacterium , Mycobacterium Nocardia Propionibacterium Tropheryma ), soil inhabitants (e.g., Micromonospora Streptomyces species), plant commensals Frankia spp.), gastrointestinal ( Bifidobacterium spp.). important role symbionts plant-associated microbial communities. This review presents update on biology this phylum.

Language: Английский

Citations

1786
Antibiotics: past, present and future DOI Creative Commons
Matthew I. Hutchings, Andrew W. Truman, Barrie Wilkinson

et al.

Current Opinion in Microbiology, Journal Year: 2019, Volume and Issue: 51, P. 72 - 80

Published: Oct. 1, 2019

The first antibiotic, salvarsan, was deployed in 1910. In just over 100 years antibiotics have drastically changed modern medicine and extended the average human lifespan by 23 years. discovery of penicillin 1928 started golden age natural product antibiotic that peaked mid-1950s. Since then, a gradual decline development evolution drug resistance many pathogens has led to current antimicrobial crisis. Here we give an overview history discovery, major classes where they come from. We argue future looks bright as new technologies such genome mining editing are discover products with diverse bioactivities. also report on state development, 45 drugs currently going through clinical trials pipeline, including several novel modes action phase 3 trials. Overall, there promising signs for but changes financial models required translate scientific advances into clinically approved antibiotics.

Language: Английский

Citations

1690
Human commensals producing a novel antibiotic impair pathogen colonization DOI

Alexander Zipperer,

Martin C. Konnerth,

Claudia Laux

et al.

Nature, Journal Year: 2016, Volume and Issue: 535(7613), P. 511 - 516

Published: July 26, 2016

Language: Английский

Citations

809
Bacteriocins of lactic acid bacteria: extending the family DOI Creative Commons

Patricia Alvarez-Sieiro,

Manuel Montalbán‐López, Dongdong Mu

et al.

Applied Microbiology and Biotechnology, Journal Year: 2016, Volume and Issue: 100(7), P. 2939 - 2951

Published: Feb. 10, 2016

Lactic acid bacteria (LAB) constitute a heterogeneous group of microorganisms that produce lactic as the major product during fermentation process. LAB are Gram-positive with great biotechnological potential in food industry. They can bacteriocins, which proteinaceous antimicrobial molecules diverse genetic origin, posttranslationally modified or not, help producer organism to outcompete other bacterial species. In this review, we focus on various types bacteriocins be found and organization regulation gene clusters responsible for their production biosynthesis, consider applications prototype from LAB. Furthermore, propose revised classification accommodate increasing number classes reported over last years.

Language: Английский

Citations

637
The Science of Antibiotic Discovery DOI Creative Commons
Kim Lewis

Cell, Journal Year: 2020, Volume and Issue: 181(1), P. 29 - 45

Published: March 19, 2020

Language: Английский

Citations

619
Retrospective analysis of natural products provides insights for future discovery trends DOI Open Access
Cameron R. Pye, Matthew J. Bertin, R. Scott Lokey

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(22), P. 5601 - 5606

Published: May 1, 2017

Significance Natural products research seems to be at a critical juncture in terms of its relevance modern biological science. We have evaluated this landscape chemical diversity ask key questions, including the following. How has rate discovery new natural progressed over past 70 y? Has product structural novelty changed as function time? novel declined recent years? Does exploring taxonomic space afford an advantage compound discovery? Is it possible estimate how close we are describing all covered by products? And, finally, is there still value for biologically active

Language: Английский

Citations

473
Synthetic biology to access and expand nature's chemical diversity DOI
Michael J. Smanski, Hui Zhou, Jan Claesen

et al.

Nature Reviews Microbiology, Journal Year: 2016, Volume and Issue: 14(3), P. 135 - 149

Published: Feb. 15, 2016

Language: Английский

Citations

447
Actinomycetes: still a source of novel antibiotics DOI
Olga Genilloud

Natural Product Reports, Journal Year: 2017, Volume and Issue: 34(10), P. 1203 - 1232

Published: Jan. 1, 2017

An update on last ten years of actinomycetes antibiotic discovery, including recent key molecules in clinical development and overlooked compounds discovered using novel strategies.

Language: Английский

Citations

387
Chemical ecology of antibiotic production by actinomycetes DOI Creative Commons
Anne van der Meij, Sarah F. Worsley, Matthew I. Hutchings

et al.

FEMS Microbiology Reviews, Journal Year: 2017, Volume and Issue: 41(3), P. 392 - 416

Published: Feb. 15, 2017

Actinomycetes are a diverse family of filamentous bacteria that produce plethora natural products relevant for agriculture, biotechnology and medicine, including the majority antibiotics we use in clinic. Rather than as free-living bacteria, many actinomycetes have evolved to live symbiosis with among others plants, fungi, insects sponges. As common theme, these organisms profit from enzymes produced by actinomycetes, example, protection against pathogenic microbes, growth promotion or degradation complex polymers such lignocellulose. At same time, benefit resources hosts they interact with. Evidence is accumulating interactions control expression biosynthetic gene clusters played major role evolution high chemical diversity actinomycete-produced secondary metabolites. Many poorly expressed under laboratory conditions, but likely response host-specific demands. Here, review environmental triggers cues product formation provide pointers how insights may be harnessed drug discovery.

Language: Английский

Citations

378