Blood‐brain barrier breakdown, neuroinflammation, and cognitive decline in older adults DOI
Gene L. Bowman, Loı̈c Dayon,

Richard Kirkland

et al.

Alzheimer s & Dementia, Journal Year: 2018, Volume and Issue: 14(12), P. 1640 - 1650

Published: Aug. 14, 2018

Abstract Introduction Blood‐brain barrier (BBB) breakdown is observed in older versus younger adults and late‐onset Alzheimer's disease age‐matched controls, but its causes consequences aging are unclear. We tested the hypothesis that BBB associated with cognitive decline inflammation nondemented elders. Methods Cerebrospinal fluid serum inflammatory markers were measured using sandwich immunoassays 120 subjects. Least Absolute Shrinkage Selection Operator‐logistic regression selected cerebrospinal signatures best classified impairment defined by albumin index ≥9. Linear examined changes Clinical Dementia Rating sum of boxes as a function integrity at baseline. Results Mean age was 70 years, mean Mini–Mental State Examination 27, recorded 13.5%. ( P = .015). intercellular adhesion molecule‐1, vascular endothelial growth factor, interleukin‐8, amyloid A, macrophage derived chemokine, gender generated an area under curve 0.95 for impairment, IL‐16, VEGF‐D, IL‐15, other variables AUC 0.92 impairment. Discussion more rapid decline. Inflammatory mechanisms, including cell adhesion, neutrophil migration, lipid metabolism, angiogenesis may be implicated.

Language: Английский

Brain capillary pericytes exert a substantial but slow influence on blood flow DOI
David A. Hartmann,

Andrée‐Anne Berthiaume,

Roger I. Grant

et al.

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(5), P. 633 - 645

Published: Feb. 18, 2021

Language: Английский

Citations

284
Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis DOI
Christopher M. Henstridge, Bradley T. Hyman, Tara L. Spires‐Jones

et al.

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(2), P. 94 - 108

Published: Jan. 14, 2019

Language: Английский

Citations

281
Restoration of brain circulation and cellular functions hours post-mortem DOI

Zvonimir Vrselja,

Stefano G. Daniele,

John Silbereis

et al.

Nature, Journal Year: 2019, Volume and Issue: 568(7752), P. 336 - 343

Published: April 17, 2019

Language: Английский

Citations

273
Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease DOI Open Access
Kalil Alves de Lima, Justin Rustenhoven, Jonathan Kipnis

et al.

Annual Review of Immunology, Journal Year: 2020, Volume and Issue: 38(1), P. 597 - 620

Published: April 26, 2020

Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous exciting findings on microglia, the resident macrophages of central nervous system (CNS). This review addresses meningeal immunity, less-studied aspect neuroimmune interactions. The meninges, triple layer membranes—the pia mater, arachnoid and dura mater—surround CNS, encompassing cerebrospinal fluid produced by choroid plexus epithelium. Unlike adjacent brain parenchyma, meninges contain wide repertoire immune cells. These constitute which is primarily concerned with surveillance and—according to recent evidence—also participates in postinjury CNS recovery, chronic neurodegenerative conditions, even higher function. Meningeal immunity come under spotlight owing characterization lymphatic vessels draining CNS. Here, we current state our understanding its effects healthy diseased brains.

Language: Английский

Citations

264
Blood‐brain barrier breakdown, neuroinflammation, and cognitive decline in older adults DOI
Gene L. Bowman, Loı̈c Dayon,

Richard Kirkland

et al.

Alzheimer s & Dementia, Journal Year: 2018, Volume and Issue: 14(12), P. 1640 - 1650

Published: Aug. 14, 2018

Abstract Introduction Blood‐brain barrier (BBB) breakdown is observed in older versus younger adults and late‐onset Alzheimer's disease age‐matched controls, but its causes consequences aging are unclear. We tested the hypothesis that BBB associated with cognitive decline inflammation nondemented elders. Methods Cerebrospinal fluid serum inflammatory markers were measured using sandwich immunoassays 120 subjects. Least Absolute Shrinkage Selection Operator‐logistic regression selected cerebrospinal signatures best classified impairment defined by albumin index ≥9. Linear examined changes Clinical Dementia Rating sum of boxes as a function integrity at baseline. Results Mean age was 70 years, mean Mini–Mental State Examination 27, recorded 13.5%. ( P = .015). intercellular adhesion molecule‐1, vascular endothelial growth factor, interleukin‐8, amyloid A, macrophage derived chemokine, gender generated an area under curve 0.95 for impairment, IL‐16, VEGF‐D, IL‐15, other variables AUC 0.92 impairment. Discussion more rapid decline. Inflammatory mechanisms, including cell adhesion, neutrophil migration, lipid metabolism, angiogenesis may be implicated.

Language: Английский

Citations

240