Probing the Complexities of Astrocyte Calcium Signaling

Trends in Cell Biology, Journal Year: 2016, Volume and Issue: 26(4), P. 300 - 312

Published: Feb. 19, 2016

Language: Английский

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Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

Nature Reviews Neurology, Journal Year: 2023, Volume and Issue: 19(7), P. 395 - 409

Published: June 12, 2023

Language: Английский

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Neuronal activity determines distinct gliotransmitter release from a single astrocyte

eLife, Journal Year: 2018, Volume and Issue: 7

Published: Jan. 30, 2018

Accumulating evidence indicates that astrocytes are actively involved in brain function by regulating synaptic activity and plasticity. Different gliotransmitters, such as glutamate, ATP, GABA or D-serine, released form have been shown to induce different forms of regulation. However, whether a single astrocyte may release gliotransmitters is unknown. Here we show mouse hippocampal activated endogenous (neuron-released endocannabinoids GABA) exogenous (single Ca2+ uncaging) stimuli modulate putative CA3-CA1 synapses. The astrocyte-mediated modulation was biphasic consisted an initial glutamate-mediated potentiation followed purinergic-mediated depression neurotransmitter release. temporal dynamic properties this regulation depended on the firing frequency duration neuronal stimulated astrocytes. Present results indicate can decode and, response, distinct differentially regulate neurotransmission at

Language: Английский

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LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia

Neuron, Journal Year: 2020, Volume and Issue: 108(5), P. 919 - 936.e11

Published: Sept. 24, 2020

Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circuits. Memory formation the brain is associated with synaptic remodeling, but how affects PAPs and therefore extrasynaptic poorly understood. Here, we used advanced imaging methods, situ vivo, to find that a classical memory mechanism, long-term potentiation (LTP), triggers withdrawal from potentiated synapses. Optical sensors combined patch-clamp 3D molecular localization reveal LTP induction thus prompts spatial retreat transporters, boosting spillover NMDA-receptor-mediated inter-synaptic cross-talk. The LTP-triggered PAP involves NKCC1 actin-controlling protein cofilin does not depend on major Ca

Language: Английский

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Astrocytic control of synaptic function

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2017, Volume and Issue: 372(1715), P. 20160154 - 20160154

Published: Jan. 17, 2017

Astrocytes intimately interact with synapses, both morphologically and, as evidenced in the past 20 years, at functional level. Ultrathin astrocytic processes contact and sometimes enwrap synaptic elements, sense transmission shape or alter signal by releasing signalling molecules. Yet, consequences of such interactions terms information processing brain remain very elusive. This is largely due to two major constraints: (i) exquisitely complex, dynamic ultrathin nature distal that renders their investigation highly challenging (ii) our lack understanding how encoded local global fluctuations intracellular calcium concentrations astrocytes. Here, we will review existing anatomical evidence between astrocytes it underlies a role for computation information.This article part themed issue 'Integrating Hebbian homeostatic plasticity'.

Language: Английский

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