Metabolic reprogramming in triple-negative breast cancer DOI Creative Commons
Zhanyu Wang,

Qianjin Jiang,

Chenfang Dong

et al.

Cancer Biology and Medicine, Journal Year: 2020, Volume and Issue: 17(1), P. 44 - 59

Published: Jan. 1, 2020

Since triple-negative breast cancer (TNBC) was first defined over a decade ago, increasing studies have focused on its genetic and molecular characteristics. Patients diagnosed with TNBC, compared to those other subtypes, relatively poor outcomes due high tumor aggressiveness lack of targeted treatment. Metabolic reprogramming, an emerging hallmark cancer, is hijacked by TNBC fulfill bioenergetic biosynthetic demands; maintain the redox balance; further promote oncogenic signaling, cell proliferation, metastasis. Understanding mechanisms metabolic remodeling may guide design strategies for effective intervention TNBC. Here, we review reprogramming glycolysis, oxidative phosphorylation, amino acid metabolism, lipid branched pathways in explore opportunities new biomarkers, imaging modalities, metabolically therapies.

Language: Английский

mTOR signalling and cellular metabolism are mutual determinants in cancer DOI
Dirk Mossmann, Sujin Park, Michael N. Hall

et al.

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(12), P. 744 - 757

Published: Nov. 13, 2018

Language: Английский

Citations

910

Glutaminolysis: A Hallmark of Cancer Metabolism DOI Open Access
Lifeng Yang, Sriram Venneti, Deepak Nagrath

et al.

Annual Review of Biomedical Engineering, Journal Year: 2017, Volume and Issue: 19(1), P. 163 - 194

Published: March 16, 2017

Glutamine is the most abundant circulating amino acid in blood and muscle critical for many fundamental cell functions cancer cells, including synthesis of metabolites that maintain mitochondrial metabolism; generation antioxidants to remove reactive oxygen species; nonessential acids (NEAAs), purines, pyrimidines, fatty cellular replication; activation signaling. In light pleiotropic role glutamine a comprehensive understanding metabolism essential development metabolic therapeutic strategies targeting cells. this article, we review oncogene-, tumor suppressor-, microenvironment-mediated regulation We describe mechanism glutamine's proliferation, metastasis, global methylation. Furthermore, highlight potential emphasize clinical application vivo assessment identifying new ways treat patients through glutamine-based therapy.

Language: Английский

Citations

711

Nutrient sensing and TOR signaling in yeast and mammals DOI
Asier González, Michael N. Hall

The EMBO Journal, Journal Year: 2017, Volume and Issue: 36(4), P. 397 - 408

Published: Jan. 17, 2017

Language: Английский

Citations

666

Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine DOI
Ji Zhang, Natalya N. Pavlova, Craig B. Thompson

et al.

The EMBO Journal, Journal Year: 2017, Volume and Issue: 36(10), P. 1302 - 1315

Published: April 18, 2017

Language: Английский

Citations

547

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells DOI
Inge M. N. Wortel,

Laurens T. van der Meer,

Michael S. Kilberg

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2017, Volume and Issue: 28(11), P. 794 - 806

Published: Aug. 7, 2017

Language: Английский

Citations

500

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models DOI
M. Schulte,

Allie Fu,

Ping Zhao

et al.

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(2), P. 194 - 202

Published: Jan. 15, 2018

Language: Английский

Citations

395

Amino acid transporters revisited: New views in health and disease DOI
Palanivel Kandasamy, Gergely Gyimesi, Yoshikatsu Kanai

et al.

Trends in Biochemical Sciences, Journal Year: 2018, Volume and Issue: 43(10), P. 752 - 789

Published: Aug. 31, 2018

Language: Английский

Citations

393

Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy DOI Creative Commons
Jie Yin, Wenkai Ren, Xingguo Huang

et al.

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: July 30, 2018

Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components nucleotides in proliferation, thus impaired purine metabolism associated with the progression The de novo biosynthesis depends on six enzymes to catalyze conversion phosphoribosylpyrophosphate inosine 5'-monophosphate. These cluster around mitochondria and microtubules form purinosome, which multi-enzyme complex involved requirement. In this review, we highlighted purinosome biology emphasis therapeutic potential manipulating or cancers. We also reviewed current advances our understanding mammalian target rapamycin (mTOR) for regulating formation cancers, discussed future prospects targeting treat

Language: Английский

Citations

371

Metabolism of Amino Acids in Cancer DOI Creative Commons
Zhen Wei, Xiaoyi Liu, Chunming Cheng

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 8

Published: Jan. 12, 2021

Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism amino acids are aberrantly upregulated in many cancers that display addiction to particular acids. Amino facilitate the survival proliferation cancer cells under genotoxic, oxidative, nutritional stress. Thus, targeting acid is becoming potential therapeutic strategy for patients. In this review, we will systematically summarize recent progress malignancy discuss their interconnection with mammalian target rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth immunity, ferroptosis. Finally, highlight applications.

Language: Английский

Citations

309

Glutamine transporters in mammalian cells and their functions in physiology and cancer DOI Creative Commons
Yangzom D. Bhutia, Vadivel Ganapathy

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2015, Volume and Issue: 1863(10), P. 2531 - 2539

Published: Dec. 24, 2015

Language: Английский

Citations

293