Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1879(1), P. 189051 - 189051
Published: Dec. 13, 2023
Language: Английский
Research, Journal Year: 2024, Volume and Issue: 7
Published: Jan. 1, 2024
Hepatocellular carcinoma (HCC) was characterized as being hypervascular. In the present study, we generated a single-cell spatial transcriptomic landscape of vasculogenic etiology HCC and illustrated overexpressed Golgi phosphoprotein 73 (GP73) cells exerting cellular communication with vascular endothelial high pro-angiogenesis potential via multiple receptor-ligand interactions in process tumor development. Specifically, uncovered an interactive GP73-mediated regulatory network coordinated c-Myc, lactate, Janus kinase 2/signal transducer activator transcription 3 (JAK2/STAT3) pathway, endoplasmic reticulum stress (ERS) signals elucidated its pro-angiogenic roles vitro vivo. Mechanistically, found that GP73, pivotal hub gene, activated by histone lactylation which stimulated phosphorylation downstream STAT3 directly binding simultaneously enhancing glucose-regulated protein 78 (GRP78)-induced ERS. potentiates functions. Clinically, serum GP73 levels were positively correlated response to anti-angiogenic regimens essential for prognostic nomogram showing good predictive performance determining 6-month 1-year survival patients treated therapy. Taken together, aforementioned data mechanisms proved is crucial angiogenesis niche gene favorable treatment HCC.
Language: Английский
Citations
8
Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Metabolic reprogramming within the tumor microenvironment (TME) plays a critical role in driving drug resistance gastrointestinal cancers (GI), particularly through pathways of fatty acid oxidation and glycolysis. Cancer cells often rewire their metabolism to sustain growth reshape TME, creating conditions such as nutrient depletion, hypoxia, acidity that impair antitumor immune responses. Immune TME also undergo metabolic alterations, frequently adopting immunosuppressive phenotypes promote progression reduce efficacy therapies. The competition for essential nutrients, glucose, between cancer compromises functions effector cells, T cells. Additionally, by-products like lactate kynurenine further suppress activity populations, including regulatory M2 macrophages. Targeting glycolysis presents new opportunities overcome improve therapeutic outcomes GI cancers. Modulating these key has potential reinvigorate exhausted shift toward phenotypes, enhance effectiveness immunotherapies other treatments. Future strategies will require continued research into metabolism, development novel inhibitors, clinical trials evaluating combination Identifying validating biomarkers be crucial patient stratification treatment monitoring. Insights may have broader implications across multiple types, offering avenues improving treatment.
Language: Английский
Citations
1
Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)
Published: Feb. 11, 2025
Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.
Language: Английский
Citations
1
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Oral cancer represents a significant proportion of head and neck malignancies, accounting for approximately 3 % all malignant tumors worldwide. Alternative splicing (AS), post-transcriptional regulatory mechanism, is increasingly linked to development. The precise impact AS on oral progression not well understood. Bioinformatics, semi-quantitative RT-PCR, minigene reporter system detect the skipping SLC37A4 exon 7 in cancer. FRAP, live cell immunofluorescence demonstrates that SRSF9 can undergo liquid-liquid phase separation (LLPS). In vivo vitro experiments with subcutaneous graft tumors, CCK8, EdU, transwell, others were used effects its induced SLC37A4-S isoforms phenotype cells. Our investigation revealed multitude aberrant alternative events within tumor tissues, most notably pronounced gene. This anomaly leads production truncated isoform, SLC37A4-S, which associated poor prognosis significantly augments proliferation metastatic potential cells relative wild-type SLC37A4-L. Mechanically, may play role SLC37A4. Furthermore, capable undergoing LLPS, process driven by arginine-serine-rich (RS) domain. Disruption LLPS through use inhibitors or mutants effectively prevents influence Significantly, our research both regulated contribute cisplatin chemotherapy resistance study elucidates mechanism mediates cancer, thereby establishing basis considering as therapeutic targets treatment.
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: March 6, 2024
Cancer cells have adapted to rapid tumor growth and evade immune attack by reprogramming their metabolic pathways. Glutamine is an important nitrogen resource for synthesizing amino acids nucleotides carbon source in the tricarboxylic acid (TCA) cycle lipid biosynthesis pathway. In this review, we summarize significant role of glutamine metabolism development highlight vulnerabilities targeting effective therapy. particular, review reported drugs glutaminase uptake efficient cancer treatment. Moreover, discuss current clinical test about prospective direction drug development.
Language: Английский
Citations
7
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116559 - 116559
Published: April 10, 2024
Breast cancer comprises a substantial proportion of diagnoses in women and is primary cause cancer-related mortality. While hormone-responsive cases generally have favorable prognosis, the aggressive nature triple-negative breast presents challenges, with intrinsic resistance to established treatments being persistent issue. The complexity intensifies emergence acquired resistance, further complicating management cancer. Epigenetic changes, encompassing DNA methylation, histone RNA modifications, non-coding RNAs, are acknowledged as crucial contributors heterogeneity unique epigenetic landscape harbored by each cellular component within tumor microenvironment (TME) adds great diversity intricate regulations which influence therapeutic responses. TME, sophisticated ecosystem non-cellular elements interacting cells, establishes an immunosuppressive fuels processes such growth, angiogenesis, extracellular matrix remodeling. These factors contribute challenging conditions treatment fostering hypoxic environment, inducing metabolic stress, creating physical barriers drug delivery. This article delves into complex connections between response, underlying vital interactions TME. To restore sensitivity treatment, it emphasizes need for combination therapies considering changes specific individual members Recognizing pivotal role epigenetics comprehending specificities TME essential devising more effective strategies. development reliable biomarkers patient stratification will facilitate tailored precise approaches.
Language: Английский
Citations
7
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 11, 2024
Cholangiocarcinoma (CCA) is often diagnosed late, leading to incomplete tumor removal, drug resistance and reduced chemotherapy efficacy. Curcumin has the potential for anti-cancer activity through various therapeutic properties can improve efficacy of chemotherapy. We aimed investigate synergistic effect a combination curcumin gemcitabine against CCA, targeting LAT2/glutamine pathway. This synergistically suppressed proliferation in gemcitabine-resistant CCA cells (KKU-213B
Language: Английский
Citations
7
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 28, 2024
Language: Английский
Citations
7
Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)
Published: Nov. 29, 2024
Abstract Tumor energy metabolism plays a crucial role in the occurrence, progression, and drug resistance of tumors. The study tumor has gradually become an emerging field treatment. Recent studies have shown that epigenetic regulation is closely linked to metabolism, influencing metabolic remodeling biological traits cells. This review focuses on primary pathways explores therapeutic strategies target these pathways. It covers key areas such as glycolysis, Warburg effect, mitochondrial function, oxidative phosphorylation, adaptability Additionally, this article examines regulator SWI/SNF complex specifically its interactions with glucose, lipids, amino acids. Summarizing aimed at pathways, including inhibitors mitochondrial-targeted drugs, exploitation vulnerabilities, recent developments related complexes potential targets. clinical significance, challenges, future directions research are discussed, overcome resistance, combination therapy, application new technologies.
Language: Английский
Citations
7
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: July 15, 2024
Lactylation, an emerging post-translational modification, plays a pivotal role in the initiation and progression of digestive system tumors. This study presents comprehensive review lactylation tumors, underscoring its critical involvement tumor development progression. By focusing on metabolic reprogramming, modulation microenvironment, molecular mechanisms regulating progression, potential targeting as therapeutic strategy is highlighted. The research reveals that participates gene expression regulation cell signaling by affecting states histones non-histone proteins, thereby influencing pathways immune evasion cells. Furthermore, this assesses feasibility target, providing insights for clinical treatment gastrointestinal cancers. Future should concentrate elucidating lactylation, developing efficient inhibitors, validating their efficacy trials, which could transform current cancer immunotherapy approaches. In summary, emphasizes crucial tumorigenesis through detailed analysis significance.
Language: Английский
Citations
6