Cited by Eltrombopag restores proliferative capacity and adipose-osteogenic balance of mesenchymal stromal cells in low-risk myelodysplastic syndromes.

Mechanistic and therapeutic insights into the function of N6-methyladenosine in arthritic diseases DOI

Xinyue Zhou,

Yajie Wu,

Yingqiu Song

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Jan. 7, 2025

Language: Английский

Citations

WTAP-mediated m6A modification on BASP1 mRNA contributes to ferroptosis in AAA DOI

Zexiang Tian,

Wei Li, Jian Wang

et al.

General Thoracic and Cardiovascular Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

Regulation of Skeletogenic Pathways by m6A RNA Modification: A Comprehensive Review DOI

Ehsan Pashay Ahi

Calcified Tissue International, Journal Year: 2025, Volume and Issue: 116(1)

Published: April 3, 2025

Language: Английский

Citations

RNA methylation: A new perspective in osteoarthritis research DOI

Guihao Zheng,

Mengji Lu,

Yulong Ouyang

et al.

Gene, Journal Year: 2025, Volume and Issue: 959, P. 149518 - 149518

Published: April 18, 2025

Language: Английский

Citations

Regulatory mechanisms of m6A RNA methylation in esophageal cancer: a comprehensive review DOI

Long Wen, Jiang Fu, Zixu Wang

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Esophageal cancer is an aggressively malignant neoplasm characterized by a high mortality rate. Frequently diagnosed at advanced stage, it presents challenges for optimal therapeutic intervention due to its non-specific symptoms, resulting in lost opportunities effective treatment, such as surgery, radiotherapy, chemotherapy and target therapy. The N6-methyladenosine (m6A) modification represents the most critical post-transcriptional of eukaryotic messenger RNA (mRNA). reversible m6A mediated three regulatory factors: methyltransferases, demethylating enzymes, recognition proteins. These components identify bind specific methylation sites, thereby modulating essential biological functions processing, nuclear export, stability, translation degradation, which significantly influence tumorigenesis, invasion, metastasis. Given importance modification, this paper offers comprehensive examination mechanisms, functions, future implications context esophageal cancer.

Language: Английский

Citations

From bone marrow mesenchymal stem cells to diseases: the crucial role of m6A methylation in orthopedics DOI

Jing Li, Chu Zhang, Wen Yin

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 6, 2025

Elucidating the molecular mechanisms underlying orthopedic diseases is crucial for guiding therapeutic strategies and developing innovative interventions. N6-methyladenosine (m6A)-an epitranscriptomic modification-has emerged as a key regulator of cellular fate tissue homeostasis. Specifically, m6A plays pivotal role in several RNA biological processes such precursor splicing, 3'-end processing, nuclear export, translation, stability. Recent advancements indicate that methylation regulates stem cell proliferation osteogenic differentiation by modulating various signaling pathways. Extensive research has shown abnormalities contribute significantly to onset progression osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), bone tumors. This review aims summarize proteases involved their functions. The detailed which marrow mesenchymal cells (BMSCs) through direct indirect ways are also discussed, with focus on specific Finally, this analyzes roles modification development multiple diseases, offering comprehensive understanding pathophysiology these conditions proposing new directions targets treatment strategies.

Language: Английский

Citations

The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis DOI

Yuman Li,

Yue Yang,

Yuting Niu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 16, 2024

Periodontitis, delineated by the destruction of structures that support teeth, is predominantly propelled intricate immune responses. Immunomodulatory treatments offer considerable promise for management this ailment; however, modulation periodontal microenvironment to facilitate tissue regeneration presents a substantial biomedical challenge. Herein, our study investigates role Wilms’ tumor 1-associating protein (WTAP), critical m 6 A methyltransferase, in immunomodulation periodontitis and assesses its viability as therapeutic target. We observed heightened expression WTAP macrophages extracted from gingival tissues impacted periodontitis, with strong association M1 polarization. Via loss-of-function experiments, we demonstrated diminishing precipitates transition M2 macrophage phenotypes amidst inflammatory conditions, thus improving landscape. Further, RNA sequencing indirect co-culture assays indicated suppressing modulates osteoimmune responses enhances osteogenic differentiation bone marrow stromal cells. The local deployment adeno-associated virus-shWTAP murine models robustly validated targeting disease. Collectively, findings highlight crucial orchestrating macrophage-mediated proposing novel avenues immunotherapeutic interventions treatment.

Language: Английский

Citations

Wnt signaling pathway in spinal cord injury: from mechanisms to potential applications DOI

Kai Li,

Zanzhi Chen,

Xuejing Chang

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: July 24, 2024

Spinal cord injury (SCI) denotes damage to both the structure and function of spinal cord, primarily manifesting as sensory motor deficits caused by disruptions in neural transmission pathways, potentially culminating irreversible paralysis. Its pathophysiological processes are complex, with numerous molecules signaling pathways intricately involved. Notably, pronounced upregulation Wnt pathway post-SCI holds promise for regeneration repair. Activation plays a crucial role neuronal differentiation, axonal regeneration, local neuroinflammatory responses, cell apoptosis, highlighting its potential therapeutic target treating SCI. However, excessive activation can also lead negative effects, need further investigation into applicability significance This paper provides an overview latest research advancements SCI, summarizing recent progress treatment strategies associated analyzing their advantages disadvantages. Additionally, we offer insights clinical application along prospective avenues future direction.

Language: Английский

Citations

The Mechanism by Which Cyperus rotundus Ameliorates Osteoarthritis: A Work Based on Network Pharmacology DOI

Min Du, Kun He,

Shan Fan

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 7893 - 7912

Published: Oct. 1, 2024

(CR) is widely used in traditional Chinese medicine to prevent and treat a variety of diseases. However, its functions mechanism action osteoarthritis (OA) has not been elucidated. Here, comprehensive strategy combining network pharmacology, molecular docking, dynamics simulation vitro experiments was address this issue.

Language: Английский

Citations

An injectable hydrogel loaded with Icariin attenuates cartilage damage in rabbit knee osteoarthritis via Wnt/β-catenin signaling pathway DOI

Hui Zheng,

Limin Qu,

Lei Yang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 145, P. 113725 - 113725

Published: Dec. 11, 2024

Language: Английский

Citations