Chuanxiong Qingnao Granules (CQG) alleviates nitroglycerin-induced migraine-like pain in rats by Glycerophospholipid metabolism and PI3K/Akt signaling pathway

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156336 - 156336

Published: Dec. 17, 2024

Language: Английский

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Lipidome analyses reveal radiation induced remodeling of glycerophospholipid unsaturation in lung tumor

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 24, 2024

Radiotherapy is a pivotal treatment for lung cancer, significantly impacting tumor control and patient quality of life. Despite its benefits, the molecular mechanisms underlying radiotherapy-induced biological alterations in cancer cells remain inadequately understood. In this study, we employed mass spectrometry-based lipidomics approach to investigate lipid profile changes mouse model post-radiation. Lewis carcinoma (LLC) were injected into C57BL/6J mice, followed by radiation with varying split doses. Our results showed an increase sterol lipids decrease glycerolipids, specifically triacylglycerides, indicating disrupted storage. Additionally, observed significant glycerophospholipid unsaturation, suggesting remodeling membrane properties that may influence cell survival. Linear regression analysis demonstrated negative correlation between unsaturation index weight, potential role radiation-induced death. These findings provide new insights metabolic pathways affected radiotherapy could inform development improved therapeutic strategies treatment.

Language: Английский

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MitoMAMMAL: a genome scale model of mammalian mitochondria predicts cardiac and BAT metabolism

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Abstract Mitochondria perform several essential functions in order to maintain cellular homeostasis and mitochondrial metabolism is inherently flexible allow correct function a wide range of tissues. Dysregulated can therefore affect different tissues ways which presents experimental challenges understanding the pathology diseases. System-level metabolic modelling useful gaining in-depth insights into tissue-specific metabolism, yet despite mouse being common model organism used research, there currently no specific available. In this work, building upon similarity between human we have created mitoMammal, genome-scale that contains gene-product reaction rules. MitoMammal able metabolism. To demonstrate feature, using an adapted E-Flux2 algorithm, first integrated proteomic data extracted from mitochondria isolated cardiomyocytes brown adipocyte tissue. We then transcriptomic vitro differentiated adipose cells modelled context flux balance analysis. all three simulations, mitoMammal made mostly accurate, some novel predictions relating energy adipocytes. This demonstrates its usefulness research cardiac disease diabetes both contexts.

Language: Английский

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Deciphering the Metabolic Basis and Molecular Circuitry of the Warburg Paradox in Lymphoma

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3606 - 3606

Published: Oct. 25, 2024

: Warburg's metabolic paradox illustrates that malignant cells require both glucose and oxygen to survive, even after converting into lactate. It remains unclear whether sparing from oxidation intersects with TCA cycle continuity if this confers any advantage in proliferating cancers. This study seeks understand the mechanistic basis of its overall implications for lymphomagenesis.

Language: Английский

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MitoMAMMAL: a genome scale model of mammalian mitochondria predicts cardiac and BAT metabolism

Bioinformatics Advances, Journal Year: 2024, Volume and Issue: 5(1)

Published: Nov. 5, 2024

Abstract Motivation Mitochondria are essential for cellular metabolism and inherently flexible to allow correct function in a wide range of tissues. Consequently, dysregulated mitochondrial affects different tissues ways leading challenges understanding the pathology diseases. System-level metabolic modelling is useful studying tissue-specific metabolism, yet despite mouse being common model organism research, no specific currently available. Results Building upon similarity between human we present mitoMammal, genome-scale that contains gene-product reaction rules. MitoMammal able metabolism. To demonstrate this, using an adapted E-Flux algorithm, integrated proteomic data from mitochondria isolated cardiomyocytes brown adipocyte tissue, as well transcriptomic vitro differentiated adipocytes modelled context flux balance analysis. In all three simulations, mitoMammal made mostly accurate, some novel predictions relating energy adipocytes. This demonstrates its usefulness research cardiac disease diabetes both contexts. Availability implementation The Jupyter Notebook available at: https://gitlab.com/habermann_lab/mitomammal.

Language: Английский

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Species differences in glycerol-3-phosphate metabolism reveals trade-offs between metabolic adaptations and cell proliferation

Biochimica et Biophysica Acta (BBA) - Bioenergetics, Journal Year: 2024, Volume and Issue: unknown, P. 149530 - 149530

Published: Dec. 1, 2024

Language: Английский

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Accelerated Sarcopenia Phenotype in the DJ-1/Park7-Knockout Zebrafish

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1509 - 1509

Published: Dec. 11, 2024

Age-dependent loss of muscle mass and function is associated with oxidative stress. DJ-1/

Language: Английский

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Metabolic Function of the Adipose Tissue

Contemporary Endocrinology, Journal Year: 2024, Volume and Issue: unknown, P. 93 - 123

Published: Jan. 1, 2024

Language: Английский

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Exposure to PCB52 (2,2′,5,5′-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 113, P. 104612 - 104612

Published: Dec. 13, 2024

Language: Английский

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