Interplay of Transcriptomic Regulation, Microbiota, and Signaling Pathways in Lung and Gut Inflammation-Induced Tumorigenesis DOI Creative Commons
Beatriz Andrea Otálora-Otálora, César Payán‐Gómez, Juan Javier López Rivera

et al.

Cells, Journal Year: 2024, Volume and Issue: 14(1), P. 1 - 1

Published: Dec. 24, 2024

Inflammation can positively and negatively affect tumorigenesis based on the duration, scope, sequence of related events through regulation signaling pathways. A transcriptomic analysis five pulmonary arterial hypertension, twelve Crohn’s disease, ulcerative colitis high throughput sequencing datasets using R language specialized libraries gene enrichment analyses identified a regulatory network in each inflammatory disease. IRF9 LINC01089 hypertension are to pathways like MAPK, NOTCH, human papillomavirus, hepatitis c infection. ZNF91 TP53TG1 disease PPAR, metabolic ZNF91, VDR, DLEU1, SATB2-AS1, AMPK, The activation might be interaction characteristic microbiota with lung gut cell receptors present membrane rafts complexes. highlights impact several coding non-coding RNAs, suggesting their relationship unlocking phenotypic plasticity for acquisition hallmarks cancer during adaptation phenotypes.

Language: Английский

Delving Into lncRNA‐Mediated Regulation of Autophagy‐Associated Signaling Pathways in the Context of Breast Cancer DOI Open Access
Chou‐Yi Hsu, Saade Abdalkareem Jasim, Pooja Bansal

et al.

Cell Biology International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Breast cancer is a multifaceted and prevalent malignancy, impacting considerable proportion of women globally. Numerous signaling pathways intricately regulate cellular functions such as growth, proliferation, survival. Among the various regulators, lncRNAs have emerged significant players despite their inability to encode proteins. An expanding body literature underscores pivotal roles play in biology, particularly context breast cancer. Autophagy, process dedicated degradation recycling components, now recognized crucial factor initiation progression. The interplay between lncRNAs, pathways, autophagy pathophysiology remains an active area investigation. Researchers identified specific that are dysregulated patients, influencing modulation key pathways. Using experimental methodologies bioinformatics approaches, multiple been elucidated, providing deeper insights into contributions pathogenesis metastatic processes. In summary, pathophysiological landscape characterized by complex interactions involving lncRNA-mediated autophagy. This understanding paves way for identifying novel therapeutic targets, prognostic markers, diagnostic ultimately contributing improved treatment outcomes management.

Language: Английский

Citations

1
Single-Cell Transcriptomic Approaches for Decoding Non-Coding RNA Mechanisms in Colorectal Cancer DOI Creative Commons
Mahnoor Gondal, Hafiz Muhammad Umer Farooqi

Non-Coding RNA, Journal Year: 2025, Volume and Issue: 11(2), P. 24 - 24

Published: March 10, 2025

Non-coding RNAs (ncRNAs) play crucial roles in colorectal cancer (CRC) development and progression. Recent developments single-cell transcriptome profiling methods have revealed surprising levels of expression variability among seemingly homogeneous cells, suggesting the existence many more cell types than previously estimated. This review synthesizes recent advances ncRNA research CRC, emphasizing bioinformatics approaches for their analysis. We explore computational tools used identification, characterization, functional prediction with a focus on RNA sequencing (scRNA-seq) data. The highlights key strategies, including sequence-based structure-based approaches, machine learning applications, multi-omics data integration. discuss how these techniques can be applied to analyze differential expression, perform enrichment, construct regulatory networks involving ncRNAs CRC. Additionally, we examine role leveraging as diagnostic prognostic biomarkers also scRNA-seq studies revealing heterogeneity aims provide comprehensive overview current state CRC outline future directions this rapidly evolving field, integration experimental validation advance our understanding biology

Language: Английский

Citations

0
Unveiling the clinical significance of RNA pseudouridine in colorectal cancer DOI
Jiehua Li, Xuanfei Li,

Xiaole Zhao

et al.

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Citations

0
Interplay of Transcriptomic Regulation, Microbiota, and Signaling Pathways in Lung and Gut Inflammation-Induced Tumorigenesis DOI Creative Commons
Beatriz Andrea Otálora-Otálora, César Payán‐Gómez, Juan Javier López Rivera

et al.

Cells, Journal Year: 2024, Volume and Issue: 14(1), P. 1 - 1

Published: Dec. 24, 2024

Inflammation can positively and negatively affect tumorigenesis based on the duration, scope, sequence of related events through regulation signaling pathways. A transcriptomic analysis five pulmonary arterial hypertension, twelve Crohn’s disease, ulcerative colitis high throughput sequencing datasets using R language specialized libraries gene enrichment analyses identified a regulatory network in each inflammatory disease. IRF9 LINC01089 hypertension are to pathways like MAPK, NOTCH, human papillomavirus, hepatitis c infection. ZNF91 TP53TG1 disease PPAR, metabolic ZNF91, VDR, DLEU1, SATB2-AS1, AMPK, The activation might be interaction characteristic microbiota with lung gut cell receptors present membrane rafts complexes. highlights impact several coding non-coding RNAs, suggesting their relationship unlocking phenotypic plasticity for acquisition hallmarks cancer during adaptation phenotypes.

Language: Английский

Citations

0