Time-restricted eating to address persistent cancer-related fatigue among cancer survivors: A randomized controlled trial
Abstract
Purpose:
Time-restricted
eating
(TRE)
helps
regulate
rest-activity
rhythms,
blood
glucose,
and
other
diurnally
regulated
energetics
processes,
which
may
have
implications
for
persistent
fatigue.
In
a
randomized
controlled
trial,
we
tested
the
effects
of
TRE
vs.
control
on
fatigue
in
cancer
survivorship.
Methods:
Adult
survivors
were
recruited
who
2
months
to
years
post-treatment
reported
moderate
severe
Participants
1:1,
TRE:control
all
received
individualized
nutrition
counseling.
The
group
self-selected
10-hour
window
12
weeks.
At
baseline,
week
6,
12,
participants
asked
log
instances,
complete
Functional
Assessment
Chronic
Illness
Therapy-Fatigue
questionnaire
(FACIT-F,
higher
score=less
fatigue),
wear
an
actigraph
continuous
glucose
monitor.
Results:
Thirty
completed
baseline
assessments
(77%
female,
53%
Black/African
American,
43%
White,
7%
Hispanic;
54.1±14.7
old;
87%
with
cancer);
25
12-week
assessments.
led
meaningful
reduction
at
controlling
levels
(change
FACIT-F
subscale=0.0±5.4
control,
4.1±5.7
TRE,
p =0.11,
effect
size
[ES]=0.70;
clinically
threshold=3.0
points).
Glucose
parameters
(e.g.,
average
interstitial
fasting
glucose)
tended
be
lower
rhythms
indicate
more
regularity
those
weeks
6
though
differences
not
statistically
significant
(p >0.19).
Conclusions:
A
12-week,
nutritionist-led
program
less
than
control.
Continued
study
patterns
are
warranted
optimize
this
pattern
address
cancer-related
Clinicaltrials.gov
identifier:
NCT05256888,
registered
02/2022
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 25, 2024
Language: Английский