Molybdenum nanodots act as antioxidants for photothermal therapy osteoarthritis

Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122909 - 122909

Published: Oct. 22, 2024

Language: Английский

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Impact of high standard farmland construction policy on chemical fertilizer reduction: a case study of China

Frontiers in Environmental Science, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 28, 2023

Promoting chemical fertilizer (CF) reduction is an inevitable requirement for achieving high-quality agricultural development, and high standard farmland construction (HSFC) provides a new path promoting CF reduction. Takes the implementation of HSFC policy as starting point, this paper uses provincial panel data China from 2005 to 2017 analyze impact on its mechanism action by using continuous difference-in-difference (DID) model mediating model. The baseline regression results show that implementing has reduced amount per unit area 8.9 % average, which significant effect. analysis shows can promote improving mechanization level expanding scale operations in agriculture. heterogeneity natural geographical location dimension, effect eastern central regions more obvious; In dimension functional areas grain production, major grain-producing obvious. Therefore, future, it necessary continue vigorously give full play effective role should development large-scale operation agriculture further strengthen western region non-major areas.

Language: Английский

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Investigation of optical wireless power transmission across biological tissue using NIR light considering safe irradiance level

Results in Optics, Journal Year: 2025, Volume and Issue: unknown, P. 100801 - 100801

Published: March 1, 2025

Language: Английский

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Blue light-emitting diode promotes mineralization of stem cells from the apical papilla via cryptochrome 1/Wnt/β-catenin signaling

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: April 1, 2025

Language: Английский

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Enhancing Biodegradable Bone Plate Performance: Stereocomplex Polylactic Acid for Improved Mechanical Properties and Near-Infrared Transparency

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

The use of biodegradable materials in bone plates offers remarkable advantages; however, their application fixation is limited by brittleness. Moreover, treatments tailored to patient conditions are needed orthopedics. In this study, were fabricated with stereocomplex polylactic acid (scPLA) and the effects poly(d-lactic acid) molecular weight scPLA blending ratios analyzed. Although modulus values poly(l-lactic (PLLA) similar, strain resistance improved at higher proportions. enhanced elongation was owing presence tie molecules within as opposed single PLA chains. exhibited mechanical properties transparency optical near-infrared ranges. characterized a smaller crystallite size. These combined its biocompatibility indicate potential for various diagnostic therapeutic orthopedic applications. Comparisons commercial PLLA-based show no significant differences vivo bone-healing ability.

Language: Английский

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The Effects and Mechanisms of PBM Therapy in Accelerating Orthodontic Tooth Movement

Biomolecules, Journal Year: 2023, Volume and Issue: 13(7), P. 1140 - 1140

Published: July 17, 2023

Malocclusion is one of the three major diseases, incidence which could reach 56% imperiled oral and systemic health in world today. Orthodontics still primary method to solve problem. However, it clear that many orthodontic complications are associated with courses long-term therapy. Photobiomodulation (PBM) therapy be used as a popular way shorten course treatment by nearly 26% 40%. In this review, efficacy cells animals, mechanisms, relevant cytokines signaling, clinical trials applications, future developments PBM orthodontics were evaluated demonstrate its validity. Simultaneously, based on mechanisms present findings, acceleration tooth movement (OTM) caused explored relation four aspects, including blood vessels, inflammatory response, collagen fibers, mineralized tissues. Also, cooperative effects translation have been growing numbers studies. Up now, has gaining popularity for non-invasive nature, easy operation, painless procedures. validity exact mechanism an adjuvant not fully elucidated. Therefore, review summarizes OTM comprehensively from various aspects was designed provide evidence-based platform research development light-related devices.

Language: Английский

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Photobiomodulation Dose–Response on Adipose-Derived Stem Cell Osteogenesis in 3D Cultures

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9176 - 9176

Published: Aug. 23, 2024

Osteoporosis and other degenerative bone diseases pose significant challenges to global healthcare systems due their prevalence impact on quality of life. Current treatments often alleviate symptoms without fully restoring damaged tissue, highlighting the need for innovative approaches like stem cell therapy. Adipose-derived mesenchymal cells (ADMSCs) are particularly promising accessibility, abundant supply, strong differentiation potential. However, ADMSCs tend favor adipogenic pathways, necessitating use inducers (DIs), three-dimensional (3D) hydrogel environments, photobiomodulation (PBM) achieve targeted osteogenic differentiation. This study investigated combined effects DIs, a fast-dextran matrix, PBM at specific wavelengths fluences proliferation immortalized into osteoblasts. Near-infrared (NIR) green (G) light, as well combination, were used with 3 J/cm

Language: Английский

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NIR-responsive nano-holed titanium alloy surfaces: a photothermally activated antimicrobial biointerface

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(36), P. 8993 - 9004

Published: Jan. 1, 2024

Among external stimuli-responsive therapy approaches, those using near infrared (NIR) light irradiation have attracted significant attention to treat bone-related diseases and bone tissue regeneration. Therefore, the development of metallic biomaterials sensitive NIR stimuli is an important area research in orthopaedics. In this study, we generated situ prism-shaped silver nanoparticles (p-AgNPs) a biomorphic nano-holed TiO2 coating on Ti6Al4V alloy (a-Ti6Al4V). Insertion p-AgNPs does not disturb periodically arranged sub-wavelength-sized unit cell a-Ti6Al4V dielectric structure, while they exacerbate its peculiar optical response, which results higher reflectivity high efficiency photothermal energy conversion suitable bacterial annihilation. Together, these open promising path toward strategic therapeutic procedures, providing novel insights into precision medicine.

Language: Английский

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The specificities, influencing factors, and medical implications of bone circadian rhythms

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(13)

Published: June 25, 2024

Abstract Physiological processes within the human body are regulated in approximately 24‐h cycles known as circadian rhythms, serving to adapt environmental changes. Bone rhythms play pivotal roles bone development, metabolism, mineralization, and remodeling processes. exhibit cell specificity, different cells display various expressions of clock genes. Multiple factors, including light, feeding, exercise, temperature, affect diurnal through sympathetic nervous system hormones. Disruptions contribute onset skeletal disorders such osteoporosis, osteoarthritis hypoplasia. Conversely, these diseases can be effectively treated when aimed at cells, rhythmic genes drug targets. In this review, we describe unique physiological activities cells. Then summarize factors synchronizing with underlying mechanisms. Based on aim build an overall understanding new preventive therapeutic strategies for disorders.

Language: Английский

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Near-Infrared Responsive Properties of Bone Repair Scaffolds Facilitated by Specific Osteoinductive Photothermal Converters for Highly Efficient Bone Repair

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(29), P. 37581 - 37595

Published: July 10, 2024

The effective repair of bone defects has long been a major challenge in clinical practice. Currently, research efforts mostly focus on achieving sufficiently good repair, with little attention paid to both and fast repair. However, highly efficient (H-efficient) which is fast, can shorten the treatment cycle facilitate rapid patient recovery. Therefore, development H-efficient material significant importance. This study incorporated previously developed osteoinductive photothermal agent (PTA) BPICT into printing paste prepare near-infrared (NIR)-responsive scaffold. Subsequently, effects therapy (PTT) drug release were assessed vitro. To further validate properties scaffold, scaffold was implanted its ability promote vivo evaluated through radiology histopathological analysis. results indicated that compared scaffolds containing only Icaritin (ICT), achieve PTT NIR irradiation, while also enabling controlled ICT from enhance Within same observation period, achieves more than significantly shortening ensuring effectiveness NIR-responsive based PTT-mediated growth factors represents feasible solution for promoting area defects.

Language: Английский

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