Theranostics, Journal Year: 2024, Volume and Issue: 14(15), P. 5945 - 5964
Published: Jan. 1, 2024
Bacteria-mediated tumor therapy has showed promising potential for cancer therapy. However, the efficacy of bacterial monotherapy treatment which can express and release therapeutic proteins in tumors been found to be unsatisfactory. To date, synergistic emerged as a approach achieve stronger outcomes compared monotherapy. It is challenge visualize these tumor-homing bacteria
Language: Английский
Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 65, P. 105854 - 105854
Published: July 23, 2024
Language: Английский
Citations
22
Biomedical Physics & Engineering Express, Journal Year: 2024, Volume and Issue: 10(5), P. 052002 - 052002
Published: Aug. 14, 2024
Abstract Purpose . This review aims to highlight current improvements in microfluidic devices designed for digestive cancer simulation. The emphasizes the use of multicellular 3D tissue engineering models understand complicated biology tumor microenvironment (TME) and progression. purpose is develop oncology research improve patients’ lives. Methods analyzes recent on mimicking cancer. It uses tissue-engineered devices, notably organs a chip (OOC), simulate human organ function lab. Cell cultivation modern three-dimensional hydrogel platforms allows precise geometry, biological components, physiological qualities. novel methodologies, key findings, technical progress explain this field’s advances. Results study discusses advances Micro systems with are emphasized. These capture complex biochemical gradients, niche variables, dynamic cell–cell interactions (TME). reveal stomach progression by duplicating TME. Recent discoveries technology have improved our understanding gut biology, as shown review. Conclusion Microfluidic play crucial role modeling furthering research. could transform drug development treatment revealing provides complete summary suggests future field professionals. review’s major goal further medical
Language: Английский
Citations
13
Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(10)
Published: Oct. 1, 2024
ABSTRACT Nanogels represent a significant innovation in the fields of nanotechnology and biomedical engineering, combining properties hydrogels nanoparticles to create versatile platforms for drug delivery, tissue bioimaging, other applications. These nanoscale hydrogels, typically ranging from 10 1000 nm, possess unique characteristics such as high water content, biocompatibility, ability encapsulate both hydrophilic hydrophobic molecules. The review explores synthesis, structural configurations, stimuli‐responsive nature nanogels, highlighting their adaptability targeted including across challenging barriers like blood–brain barrier. Furthermore, paper delves into applications particularly delivery systems, demonstrating potential revolutionize these fields. Despite promising preclinical results, challenges remain translating technologies clinical practice, issues related stability, scalability, regulatory approval. concludes by discussing future perspectives, emphasizing need further research optimize ultimately aiming enhance efficacy safety settings.
Language: Английский
Citations
11
Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Abstract Endophytic fungi represent a significant renewable resource for the discovery of pharmaceutically important compounds, offering substantial potential new drug development. Their ability to address growing issue resistance has drawn attention from researchers seeking novel, nature-derived lead molecules that can be produced on large scale meet global demand. Recent advancements in genomics, metabolomics, bioinformatics, and improved cultivation techniques have significantly aided identification characterization fungal endophytes their metabolites. Current estimates suggest there are approximately 1.20 million globally, yet only around 16% (190,000) been identified studied detail. This underscores vast untapped pharmaceutical research. Research increasingly focused transformation bioactive compounds by through chemical enzymatic processes. A notable example is anthraquinone derivative 6-O-methylalaternin, whose cytotoxic enhanced addition hydroxyl group, sharing structural similarities with its parent compound macrosporin. These structure-bioactivity studies open up avenues developing safer more effective therapeutic agents synthesizing targeted derivatives. Despite immense promise, challenges remain, particularly large-scale understanding complexities biosynthetic pathways. Additionally, genetic manipulation optimized metabolite production still infancy. Future research should aim overcome these limitations focusing efficient methods deeper exploration endophytes’ metabolic capabilities fully harness potential. Graphical
Language: Английский
Citations
1
Biotechnology and Applied Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
ABSTRACT As a significant cause of global mortality, the cancer has also economic impacts. In era therapy, mitigating side effects and costs overcoming drug resistance is crucial. Microbial species can grow inside tumor microenvironment inhibit growth through direct killing cells immunoregulatory effects. Although microbiota or their products have demonstrated anticancer effects, possibility acting as pathogens exerting in certain individuals risk. Hence, several genetically modified/engineered bacteria (GEB) been developed to this aim with ability diagnosing selective targeting destruction cancers. Additionally, GEB are expected be considerably more efficient, safer, permeable, less costly, invasive theranostic approaches compared wild types. Potential strains such Escherichia coli (Nissle 1917, MG1655), Salmonella typhimurium YB1 SL7207 ( aroA gene deletion), VNP20009 (∆msbB/∆purI) ΔppGpp (P Tet P BAD ), Listeria monocytogenes Lm at ‐LLO combat cells. When used tandem conventional treatments, substantially improve efficacy therapy outcomes. addition, public acceptance, optimal timing (s), duration dose identification, interactions other host cells, efficacy, safety quality, potential risks ethical dilemmas include major challenges.
Language: Английский
Citations
1
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)
Published: March 28, 2025
Language: Английский
Citations
1
Fibers and Polymers, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 4, 2024
Language: Английский
Citations
8
Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1017, P. 123282 - 123282
Published: July 22, 2024
Language: Английский
Citations
7
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)
Published: July 26, 2024
Abstract In recent years, advancements in microbial sequencing technology have sparked an increasing interest the bacteria residing within solid tumors and its distribution functions various tumors. Intratumoral critically modulate tumor oncogenesis development through DNA damage induction, chronic inflammation, epigenetic alterations, metabolic immune regulation, while also influencing cancer treatment efficacy by affecting drug metabolism. response to these discoveries, a variety of anti‐cancer therapies targeting microorganisms emerged. These approaches encompass oncolytic therapy utilizing tumor‐associated bacteria, design biomaterials based on intratumoral use bacterial components for delivery systems, comprehensive strategies aimed at eradication tumor‐promoting bacteria. Herein, this review article summarizes patterns different tumors, examines their impact evaluates current therapeutic centered Furthermore, challenges prospects developing drugs that target communities are explored, promising new directions treatment.
Language: Английский
Citations
6
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(12), P. 9633 - 9674
Published: July 29, 2024
Language: Английский
Citations
5