Apoptotic extracellular vesicles: mechanisms, applications, and therapeutic potential DOI Creative Commons
Dongjian Han, Zhe Li,

Fuhang Wang

et al.

Med-X, Journal Year: 2024, Volume and Issue: 2(1)

Published: Dec. 16, 2024

Abstract Apoptotic extracellular vesicles (ApoEVs) are membrane-bound released during apoptosis, crucial for intercellular communication by delivering bioactive molecules to recipient cells. These increasingly recognized their potential in tumor therapy, immune modulation, and tissue regeneration. Recent studies reveal that ApoEVs play diverse roles the medical fields. In they enhance targeted drug delivery antitumor immunity. Immune modulation is achieved presenting antigens cells, fostering specific responses. also aid regeneration, promoting wound healing repair. Advances isolation engineering techniques have improved purity functionality of ApoEVs, enabling use as therapeutic platforms. hold significant clinical transferring genetic material, proteins, other molecules. However, challenges such standardizing production, ensuring safety, addressing heterogeneity must be overcome. Future research should optimize methods, elucidate ApoEV mechanisms, develop strategies efficacy. offer promising applications cancer treatment, regulation, This review summarizes latest highlighting promise ahead. Graphical

Language: Английский

Platelet‐derived apoptotic vesicles ameliorate nonalcoholic fatty liver disease by regulating lipid metabolism via apolipoprotein A‐II DOI Creative Commons

Yuhe Jiang,

Yike Liao, Zeying Wang

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Nonalcoholic fatty liver disease (NAFLD) encompasses a broad range of conditions, commencing with simple steatosis and progressing to non‐alcoholic steatohepatitis, the possibility further deterioration into fibrosis, cirrhosis, ultimately, hepatocellular carcinoma. Unfortunately, there is currently no approved medication for treating NAFLD‐associated steatosis. This underscores need improved therapeutic approaches that can modulate lipid metabolism halt transition from chronic disease. Our previous studies have demonstrated apoptotic vesicles (apoVs), which are produced during apoptosis, show great potential in regulating homeostasis. However, whether they ameliorate NAFLD unknown. In our research, apoVs derived platelets (PLT‐apoVs) as well mesenchymal stem cells (MSC‐apoVs) were used treat NAFLD. The results showed PLT‐apoVs exhibited superior effects diminishing accumulation induced by high‐fat diet than MSC‐apoVs. Through proteomic analysis, we defined validated apolipoprotein A‐II (APOA2) regulator apoV‐mediated MSC adipogenesis, could be target enhance apoV biomedical field. Owing higher expression APOA2, better pave way apoV‐based therapy

Language: Английский

Citations

1
Apoptotic mesenchymal stem cells and their secreted apoptotic extracellular vesicles: therapeutic applications and mechanisms DOI Creative Commons

Ruoxuan Wang,

Jiao Fu, Jing He

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 21, 2025

Mesenchymal stem cells (MSCs), an accessible and less ethically controversial class of adult cells, have demonstrated significant efficacy in treating a wide range diseases both the preclinical clinical phases. However, we do not yet clear understanding mechanisms by which MSCs exert their therapeutic effects vivo. We found that transplanted go apoptotic fate within 24 h vivo irrespective route administration. Still, short-term survival affect long-term efficacy. An increasing number studies transplantation (ApoMSCs) show similar or even better than viable MSCs, including variety disease models such as inflammatory diseases, skin damage, bone organ etc. Although exact mechanism has to be explored, recent shown undergo apoptosis are phagocytosed phagocytes, thereby exerting immunomodulatory effects. The extracellular vesicles secreted ApoMSCs (MSC-ApoEVs) play role promoting immunomodulation, endogenous cell regeneration, angiogenesis due properties inheritance molecular characteristics from parental MSCs. On this basis, review aims deeply explore applications secretion MSC-ApoEVs, well challenges they face.

Language: Английский

Citations

0
Apoptotic vesicles inhibit bone marrow adiposity via wnt/β-catenin signaling DOI
Yuan Zhu,

Yaoshan Liu,

Kunkun Yang

et al.

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 29, P. 262 - 270

Published: April 1, 2025

Language: Английский

Citations

0
Apoptotic extracellular vesicles: mechanisms, applications, and therapeutic potential DOI Creative Commons
Dongjian Han, Zhe Li,

Fuhang Wang

et al.

Med-X, Journal Year: 2024, Volume and Issue: 2(1)

Published: Dec. 16, 2024

Abstract Apoptotic extracellular vesicles (ApoEVs) are membrane-bound released during apoptosis, crucial for intercellular communication by delivering bioactive molecules to recipient cells. These increasingly recognized their potential in tumor therapy, immune modulation, and tissue regeneration. Recent studies reveal that ApoEVs play diverse roles the medical fields. In they enhance targeted drug delivery antitumor immunity. Immune modulation is achieved presenting antigens cells, fostering specific responses. also aid regeneration, promoting wound healing repair. Advances isolation engineering techniques have improved purity functionality of ApoEVs, enabling use as therapeutic platforms. hold significant clinical transferring genetic material, proteins, other molecules. However, challenges such standardizing production, ensuring safety, addressing heterogeneity must be overcome. Future research should optimize methods, elucidate ApoEV mechanisms, develop strategies efficacy. offer promising applications cancer treatment, regulation, This review summarizes latest highlighting promise ahead. Graphical

Language: Английский

Citations

2