Enterococcus faecalis promotes orthodontic tooth movement in mice by M1-like macrophage polarization DOI
Zhihe Zhao, Fei Yu,

Wenxin Lu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract Probiotic-mediated therapy has garnered increasing attention for its potential role in influencing bone remodeling. Recent studies have consistently shown that the microorganisms can play a modulating reconstruction. In this study, we aim to explore impact of probiotics on accelerating orthodontic tooth movement (OTM). Potential probiotic candidates will be identified through 16S rRNA gene sequencing mouse model OTM. The relative abundance Enterococcus faecalis (E. faecalis) increased move group. To investigate osteoimmunomodulatory impact, primary periodontal ligament cells (PDLCs) were obtained from ligaments and cultured with or without conditioned media (CM) derived macrophages post-incubation E. faecalis. results demonstrated number M1-polarized macrophages, decreased osteogenic level PDLCs treated CM Subsequently, microbiota mice depleted using broad-spectrum antibiotic mixture (ABX) before being administered distance OTM been measured, alveolar analyzed micro-CT immunohistochemical staining. This study explored effects administration process immunomodulation. We assessed efficacy movement, elucidated mechanisms by which modulate M1-like macrophage polarization enhance research lead an acceleration duration treatment minimal interventions, thereby offering significant value pioneering advancements treatment.

Language: Английский

Association Between Different Biomarkers and Initial Orthodontic Tooth Movement in Children and Adults: A Systematic Review and Meta-Analysis DOI Open Access
A. Thillai Rajan,

Sumeet Ghonmode,

Suryakant Powar

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

The present systematic review aims to bridge the existing knowledge gap by evaluating influence of various biomarkers on initial orthodontic tooth movement in children and adults. A electronic search was conducted using relevant keywords across databases PubMed, Google Scholar, EBSCOhost identify articles published English until December 2023. "Risk Bias (ROB) Non-randomized Studies Interventions" (ROBINS-I) tool used assess risk bias, Grading Recommendations Assessment, Development Evaluation (GRADE) approach applied critically appraise quality evidence. total 10 studies were identified, all which non-randomised clinical trials that compared biomarker expression patients belonging growing age group (children, juveniles, or adolescents) adults, gingival crevicular fluid (GCF) saliva analysed ELISA method. Overall, younger consistently exhibited faster more pronounced biological responses forces, with levels peaking within first 72 hours force application.

Language: Английский

Citations

0
A Stress-Driven Model for Bone Density Evolution in Rats During Orthodontic Tooth Movement DOI
Bin Wu,

Mingna Li,

Fan Yang

et al.

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2025, Volume and Issue: 165, P. 106932 - 106932

Published: Feb. 10, 2025

Language: Английский

Citations

0
Engineered 3D mesenchymal stem cell aggregates with multifunctional prowess for bone regeneration: Current status and future prospects DOI Creative Commons
Linxue Zhang, Xiaojing Yuan, Rui Song

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Insulin for oral bone tissue engineering: a review on innovations in targeted insulin-loaded nanocarrier scaffold DOI

Jiyaur Rahaman,

Dhrubojyoti Mukherjee

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31

Published: Dec. 21, 2024

The occurrence of oral bone tissue degeneration and defects by osteoporosis, tooth extraction, obesity, trauma, periodontitis are major challenges for clinicians. Traditional regeneration methods often come with limitations such as donor site morbidity, limitation special shape, inflammation, resorption the implanted bone. treatment oriented biomimetic materials has achieved significant attention recently. In engineering arena, insulin gained considerable among all known biomaterials osteogenesis angiogenesis. It also exhibits osteogenic angiogenic properties interacting receptors on osteoblasts. Insulin influences remodelling both directly indirectly. acts through PI3K/Akt MAPK signalling pathways indirectly modulating RANK/RANKL/OPG pathway, which helps reduce resorption. current review reports role in cavity form scaffolds nanomaterials. Different delivery systems, utilising nanomaterials functionalised polymeric have been explored regeneration. put forward a theoretical basis future research composite

Language: Английский

Citations

1
Enterococcus faecalis promotes orthodontic tooth movement in mice by M1-like macrophage polarization DOI
Zhihe Zhao, Fei Yu,

Wenxin Lu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract Probiotic-mediated therapy has garnered increasing attention for its potential role in influencing bone remodeling. Recent studies have consistently shown that the microorganisms can play a modulating reconstruction. In this study, we aim to explore impact of probiotics on accelerating orthodontic tooth movement (OTM). Potential probiotic candidates will be identified through 16S rRNA gene sequencing mouse model OTM. The relative abundance Enterococcus faecalis (E. faecalis) increased move group. To investigate osteoimmunomodulatory impact, primary periodontal ligament cells (PDLCs) were obtained from ligaments and cultured with or without conditioned media (CM) derived macrophages post-incubation E. faecalis. results demonstrated number M1-polarized macrophages, decreased osteogenic level PDLCs treated CM Subsequently, microbiota mice depleted using broad-spectrum antibiotic mixture (ABX) before being administered distance OTM been measured, alveolar analyzed micro-CT immunohistochemical staining. This study explored effects administration process immunomodulation. We assessed efficacy movement, elucidated mechanisms by which modulate M1-like macrophage polarization enhance research lead an acceleration duration treatment minimal interventions, thereby offering significant value pioneering advancements treatment.

Language: Английский

Citations

0